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Gabre Gene Detail
Summary
  • Symbol
    Gabre
  • Name
    gamma-aminobutyric acid (GABA) A receptor, subunit epsilon
  • Feature Type
    protein coding gene
  • IDs
    MGI:1330235
    NCBI Gene: 14404
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:71300532-71318433 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome X, 37.21 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    71 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1330235
 protein coding gene ChrX:71299605-71318433 (-)
129S1/SvImJ MGP_129S1SvImJ_G0035791
 protein coding gene ChrX:67928905-67947700 (-)
A/J MGP_AJ_G0035775
 protein coding gene ChrX:68165316-68182621 (-)
AKR/J MGP_AKRJ_G0035697
 protein coding gene ChrX:70002511-70021300 (-)
BALB/cJ MGP_BALBcJ_G0035762
 protein coding gene ChrX:67190831-67209596 (-)
C3H/HeJ MGP_C3HHeJ_G0035465
 protein coding gene ChrX:68440059-68458848 (-)
C57BL/6NJ MGP_C57BL6NJ_G0036292
 protein coding gene ChrX:70010654-70029457 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0033139
 protein coding gene ChrX:67360233-67378982 (-)
CAST/EiJ MGP_CASTEiJ_G0034757
 protein coding gene ChrX:53814596-53833370 (-)
CBA/J MGP_CBAJ_G0035440
 protein coding gene ChrX:71931136-71949925 (-)
DBA/2J MGP_DBA2J_G0035593
 protein coding gene ChrX:67635959-67654755 (-)
FVB/NJ MGP_FVBNJ_G0035544
 protein coding gene ChrX:66986879-67005684 (-)
LP/J MGP_LPJ_G0035682
 protein coding gene ChrX:68779078-68797801 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0035579
 protein coding gene ChrX:74510843-74529632 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0036313
 protein coding gene ChrX:67792430-67811225 (-)
PWK/PhJ MGP_PWKPhJ_G0034457
 protein coding gene ChrX:51824832-51843993 (-)
SPRET/EiJ MGP_SPRETEiJ_G0034292
 protein coding gene ChrX:54709089-54727935 (-)
WSB/EiJ MGP_WSBEiJ_G0034899
 protein coding gene ChrX:67109281-67128055 (-)



Homology
more
  • Human Ortholog
    GABRE, gamma-aminobutyric acid type A receptor subunit epsilon
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GABRE, gamma-aminobutyric acid type A receptor subunit epsilon
  • Links
    NCBI Gene ID: 2564
    neXtProt AC: NX_P78334
    UniProt: P78334

  • Chr Location
    Xq28; chrX:151953124-151974680 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 2 alleles in 2 genetic backgrounds
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
MIce homozygous for a null allele exhibit impaired fertility and impaired response to repeated sevoflurane inhalation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    22
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    839
  • Tissues
    122
  • cDNA Data
    5
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 14404 NCBI Gene Model | MGI Sequence Detail 17902 C57BL/6J ±  kb
    transcript NM_017369 RefSeq | MGI Sequence Detail 2791 Not Specified  
    polypeptide NP_059065 RefSeq | MGI Sequence Detail 916 Not Specified  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • InterPro Domains
      IPR008099 Gamma-aminobutyric-acid A receptor epsilon subunit
      IPR006028 Gamma-aminobutyric acid A receptor/Glycine receptor alpha
      IPR038050 Neuronal acetylcholine receptor
      IPR006201 Neurotransmitter-gated ion-channel
      IPR018000 Neurotransmitter-gated ion-channel, conserved site
      IPR006202 Neurotransmitter-gated ion-channel ligand-binding domain
      IPR036734 Neurotransmitter-gated ion-channel ligand-binding domain superfamily
      IPR006029 Neurotransmitter-gated ion-channel transmembrane domain
      IPR036719 Neurotransmitter-gated ion-channel transmembrane domain superfamily
    • GlyGen
      A2AMW3 2 sites, 2 N-linked glycans (2 sites)
    Molecular
    Reagents
    less
    • All nucleic 7
      cDNA 5
      Primer pair 1
      Other 1

      Microarray probesets 3
    References
    more
    • Summaries
      All 34
      Developmental Gene Expression 5
      Gene Ontology 4
      Phenotypes 9
    • Earliest
      J:52383 Tobet SA, et al., Special relationship of gamma-aminobutyric acid to the ventromedial nucleus of the hypothalamus during embryonic development. J Comp Neurol. 1999 Mar 1;405(1):88-98
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory