Sprr3 MGI Mouse Gene Detail - MGI:1330237 - small proline-rich protein 3

Symbol

Sprr3
Name

small proline-rich protein 3
Synonyms

SPR3

Feature Type

protein coding gene
IDs

MGI:1330237
NCBI Gene: 20766
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr3:92363809-92366027 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 3, 40.14 cM
Mapping Data

5 experiments

SNPs within 2kb

151 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1330237	protein coding gene	Chr3:92363809-92366027 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0027498	protein coding gene	Chr3:92903187-92905405 (-)
A/J	MGP_AJ_G0027465	protein coding gene	Chr3:89980971-89983332 (-)
AKR/J	MGP_AKRJ_G0027430	protein coding gene	Chr3:92086676-92089315 (-)
BALB/cJ	MGP_BALBcJ_G0027473	protein coding gene	Chr3:89793243-89795923 (-)
C3H/HeJ	MGP_C3HHeJ_G0027213	protein coding gene	Chr3:92314597-92317460 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0027917	protein coding gene	Chr3:96442281-96444365 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0025266	protein coding gene	Chr3:86623648-86625877 (-)
CAST/EiJ	MGP_CASTEiJ_G0026660	protein coding gene	Chr3:91724974-91727519 (-)
CBA/J	MGP_CBAJ_G0027187	protein coding gene	Chr3:99738517-99740467 (-)
DBA/2J	MGP_DBA2J_G0027325	protein coding gene	Chr3:89305012-89307490 (-)
FVB/NJ	MGP_FVBNJ_G0027293	protein coding gene	Chr3:87473741-87475690 (-)
LP/J	MGP_LPJ_G0027433	protein coding gene	Chr3:94122620-94124849 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0027317	protein coding gene	Chr3:105999449-106001961 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0027976	protein coding gene	Chr3:91817677-91821059 (-)
PWK/PhJ	MGP_PWKPhJ_G0026393	protein coding gene	Chr3:89187892-89190053 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0026212	protein coding gene	Chr3:90153278-90158641 (-)
WSB/EiJ	MGP_WSBEiJ_G0026743	protein coding gene	Chr3:92209266-92212140 (-)

Human Ortholog

SPRR3, small proline rich protein 3

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SPRR3, small proline rich protein 3
Links

HGNC:11268

NCBI Gene ID: 6707

neXtProt AC: NX_Q9UBC9

UniProt: Q9UBC9
Chr Location

1q21.3; chr1:153001747-153003856 (+) GRCh38

MGI Vertebrate Homology

Sprr3 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: SPRR3
Gene Tree

Sprr3

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References

1 with disease annotations

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Phenotype Summary

3 phenotypes from 2 alleles in 2 genetic backgrounds
5 phenotypes from multigenic genotypes
13 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Chemically induced (other)

1
Endonuclease-mediated

1
Radiation induced

1
Targeted

4
Genomic Mutations

2 involving Sprr3
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

16 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele exhibit normal phenotype.

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All GO Annotations

6
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

725
Tissues

12
cDNA Data

5
Literature Summary

1

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

31
RefSeq

4
UniProt

1
CCDS

CCDS17558.1

Ensembl

ENSMUSG00000045539 (Evidence)
NCBI Gene

20766

			Length	Strain/Species	Flank
genomic	20766	NCBI Gene Model \| MGI Sequence Detail	2219	C57BL/6J	± kb
transcript	NM_011478	RefSeq \| MGI Sequence Detail	1222	ZRU/MplStud
polypeptide	O09116	UniProt \| EBI \| MGI Sequence Detail	238	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000015580 small proline-rich protein 3

(term hierarchy)

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All nucleic 6

Genomic 1

cDNA 5

Microarray probesets 3

Summaries

All 38

Developmental Gene Expression 1

Diseases 1

Gene Ontology 4

Phenotypes 13
Earliest

J:74930 Steinert PM, et al., Biochemical evidence that small proline-rich proteins and trichohyalin function in epithelia by modulation of the biomechanical properties of their cornified cell envelopes. J Biol Chem. 1998 May 8;273(19):11758-69
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Sprr3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr34281	Chr3:92366022-92366037 (-)	-3 bp
Tssr34280	Chr3:92364797-92364821 (-)	1,218 bp
Tssr34279	Chr3:92364638-92364648 (-)	1,384 bp
Tssr34278	Chr3:92364596-92364607 (-)	1,425 bp
Tssr34277	Chr3:92364548-92364559 (-)	1,473 bp
Tssr34276	Chr3:92364500-92364510 (-)	1,522 bp
Tssr34275	Chr3:92364164-92364191 (-)	1,849 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24