Zpr1 MGI Mouse Gene Detail - MGI:1330262

Symbol

Zpr1
Name

ZPR1 zinc finger
Synonyms

Zfp259, ZPR1

Feature Type

protein coding gene
IDs

MGI:1330262
NCBI Gene: 22687
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr9:46184362-46193941 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 9, 25.38 cM
Mapping Data

2 experiments

SNPs within 2kb

314 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1330262	protein coding gene	Chr9:46184362-46193941 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0034752	protein coding gene	Chr9:44905546-44913835 (+)
A/J	MGP_AJ_G0034733	protein coding gene	Chr9:43619807-43629456 (+)
AKR/J	MGP_AKRJ_G0034660	protein coding gene	Chr9:44509130-44517477 (+)
BALB/cJ	MGP_BALBcJ_G0034724	protein coding gene	Chr9:43340734-43350188 (+)
C3H/HeJ	MGP_C3HHeJ_G0034435	protein coding gene	Chr9:44982864-44994195 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0035245	protein coding gene	Chr9:46184948-46193412 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0032159	protein coding gene	Chr9:43149476-43158947 (+)
CAST/EiJ	MGP_CASTEiJ_G0033757	protein coding gene	Chr9:44846100-44856781 (+)
CBA/J	MGP_CBAJ_G0034407	protein coding gene	Chr9:47875803-47887853 (+)
DBA/2J	MGP_DBA2J_G0034566	protein coding gene	Chr9:43490327-43500930 (+)
FVB/NJ	MGP_FVBNJ_G0034507	protein coding gene	Chr9:42755177-42764452 (+)
LP/J	MGP_LPJ_G0034647	protein coding gene	Chr9:45223458-45231914 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0034551	protein coding gene	Chr9:49619188-49628647 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0035266	protein coding gene	Chr9:44426266-44436770 (+)
PWK/PhJ	MGP_PWKPhJ_G0033462	protein coding gene	Chr9:43412347-43421925 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0033298	protein coding gene	Chr9:44758042-44769377 (+)
WSB/EiJ	MGP_WSBEiJ_G0033870	protein coding gene	Chr9:44475523-44485831 (+)

Human Ortholog

ZPR1, ZPR1 zinc finger

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ZPR1, ZPR1 zinc finger
Synonyms

GKAF, ZNF259
Links

HGNC:13051

NCBI Gene ID: 8882

neXtProt AC: NX_O75312

UniProt: O75312
Chr Location

11q23.3; chr11:116773799-116788039 (-) GRCh38

MGI Vertebrate Homology

Zpr1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: ZPR1
Gene Tree

Zpr1

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Phenotype Summary

7 phenotypes from 1 allele in 1 genetic background
5 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

3
Gene trapped

2
Targeted

1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

20 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous null mice display embryonic lethality, fail to form a normal trophectoderm and fail to expand the inner cell mass.

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All GO Annotations

66
GO References

12

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

731
Tissues

24
cDNA Data

75
Literature Summary

8

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase zpr1

ZFIN zpr1

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All Sequences

57
RefSeq

3
UniProt

9
CCDS

CCDS23144.1

Ensembl

ENSMUSG00000032078 (Evidence)
NCBI Gene

22687

			Length	Strain/Species	Flank
genomic	22687	NCBI Gene Model \| MGI Sequence Detail	9580	C57BL/6J	± kb
transcript	NM_011752	RefSeq \| MGI Sequence Detail	2984	Not Specified
polypeptide	Q62384	UniProt \| EBI \| MGI Sequence Detail	459	Not Applicable

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UniProt

9 Sequences
Protein Ontology

PR:000017785 zinc finger protein ZPR1

(term hierarchy)
PDB

2QKD
InterPro Domains

IPR004457 Zinc finger, ZPR1-type

IPR042451 ZPR1, A/B domain

IPR040141 ZPR1 family

IPR042452 ZPR1, zinc finger domain

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All nucleic 75

cDNA 75

Microarray probesets 4

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MGI:2143010

Summaries

All 43

Developmental Gene Expression 8

Gene Ontology 12

Phenotypes 5
Earliest

J:50499 Galcheva-Gargova Z, et al., Binding of zinc finger protein ZPR1 to the epidermal growth factor receptor. Science. 1996 Jun 21;272(5269):1797-802
Latest

J:313619 Bedogni F, et al., Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Front Mol Neurosci. 2021;14:686034

TSS for Zpr1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr84909	Chr9:46184446-46184499 (+)	111 bp
Tssr84910	Chr9:46191970-46191974 (+)	7,610 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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