Dyrk4 MGI Mouse Gene Detail - MGI:1330292 - dual-specificity tyrosine phosphorylation regulated kinase 4

Symbol

Dyrk4
Name

dual-specificity tyrosine phosphorylation regulated kinase 4
Synonyms

Dyrk4a, Dyrk4b

Feature Type

protein coding gene
IDs

MGI:1330292
NCBI Gene: 101320
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

Chr6:126852983-126898802 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 6, 61.92 cM
Mapping Data

1 experiment

SNPs within 2kb

1029 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1330292	protein coding gene	Chr6:126852983-126899039 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0031307	protein coding gene	Chr6:130353790-130396598 (-)
A/J	MGP_AJ_G0031278	protein coding gene	Chr6:125388664-125431193 (-)
AKR/J	MGP_AKRJ_G0031206	protein coding gene	Chr6:128784755-128830958 (-)
BALB/cJ	MGP_BALBcJ_G0031285	protein coding gene	Chr6:124963043-125005998 (-)
C3H/HeJ	MGP_C3HHeJ_G0031009	protein coding gene	Chr6:128909938-128953338 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0031742	protein coding gene	Chr6:133752180-133802348 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0028890	protein coding gene	Chr6:122574235-122616250 (-)
CAST/EiJ	MGP_CASTEiJ_G0030390	protein coding gene	Chr6:129108311-129149536 (-)
CBA/J	MGP_CBAJ_G0030970	protein coding gene	Chr6:138883605-138931528 (-)
DBA/2J	MGP_DBA2J_G0031126	protein coding gene	Chr6:124287604-124330775 (-)
FVB/NJ	MGP_FVBNJ_G0031075	protein coding gene	Chr6:123217798-123260079 (-)
LP/J	MGP_LPJ_G0031206	protein coding gene	Chr6:130466937-130511401 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0031114	protein coding gene	Chr6:142857032-142904628 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0031777	protein coding gene	Chr6:128740753-128788081 (-)
PWK/PhJ	MGP_PWKPhJ_G0030105	protein coding gene	Chr6:122551324-122593820 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0029934	protein coding gene	Chr6:126817256-126860470 (-)
WSB/EiJ	MGP_WSBEiJ_G0030475	protein coding gene	Chr6:129108371-129152576 (-)

Human Ortholog

DYRK4, dual specificity tyrosine phosphorylation regulated kinase 4

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

DYRK4, dual specificity tyrosine phosphorylation regulated kinase 4
Links

HGNC:3095

NCBI Gene ID: 8798

neXtProt AC: NX_Q9NR20

UniProt: Q9NR20
Chr Location

12p13.32; chr12:4562208-4615302 (+) GRCh38

MGI Vertebrate Homology

Dyrk4 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: DYRK4
Gene Tree

Dyrk4

less

Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
5 phenotype references

All Mutations and Alleles

5
Endonuclease-mediated

2
Targeted

3
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

29 strains or lines available

Contrary to expectation, homozygous null males are fertile and do not exhibit any obvious dysfunction in spermatogenesis, sperm motility and fertilization.

less

All GO Annotations

15
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

3

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas

less

All Sequences

48
RefSeq

18
UniProt

2
CCDS

CCDS20559.2

Ensembl

ENSMUSG00000030345 (Evidence)
NCBI Gene

101320

			Length	Strain/Species	Flank
genomic	ENSMUSG00000030345	Ensembl Gene Model \| MGI Sequence Detail	45820	C57BL/6J	± kb
transcript	ENSMUST00000078521	Ensembl \| MGI Sequence Detail	2252	Not Applicable
polypeptide	ENSMUSP00000077606	Ensembl \| MGI Sequence Detail	632	Not Applicable

less

UniProt

2 Sequences
Protein Ontology

PR:000006785 dual specificity tyrosine-phosphorylation-regulated kinase 4

(term hierarchy)
EC

2.7.12.1
InterPro Domains

IPR042521 Dual specificity tyrosine-phosphorylation-regulated kinase

IPR017441 Protein kinase, ATP binding site

IPR000719 Protein kinase domain

IPR011009 Protein kinase-like domain superfamily

IPR050494 Serine/threonine and dual-specificity kinase

IPR008271 Serine/threonine-protein kinase, active site

less

All nucleic 3

cDNA 3

Microarray probesets 2

less

MGI:1330291, MGI:2141638

Summaries

All 27

Gene Ontology 8

Phenotypes 5
Earliest

J:50326 Becker W, et al., Sequence characteristics, subcellular localization, and substrate specificity of DYRK-related kinases, a novel family of dual specificity protein kinases. J Biol Chem. 1998 Oct 2;273(40):25893-902
Latest

J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42

TSS for Dyrk4:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr63351	Chr6:126898767-126898790 (-)	23 bp
Tssr63350	Chr6:126898754-126898764 (-)	43 bp
Tssr63349	Chr6:126854260-126854293 (-)	44,525 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24