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Hnrnpab Gene Detail
Summary
  • Symbol
    Hnrnpab
  • Name
    heterogeneous nuclear ribonucleoprotein A/B
  • Synonyms
    CBF-A, Cgbfa, Hnrpab
  • Feature Type
    protein coding gene
  • IDs
    MGI:1330294
    NCBI Gene: 15384
  • Alliance
    gene page
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:51490927-51497674 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 31.11 cM, cytoband B1.3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    177 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1330294
 protein coding gene Chr11:51490927-51497708 (-)
129S1/SvImJ MGP_129S1SvImJ_G0018269
 protein coding gene Chr11:50847671-50854415 (-)
A/J MGP_AJ_G0018238
 protein coding gene Chr11:48934308-48941055 (-)
AKR/J MGP_AKRJ_G0018208
 protein coding gene Chr11:50470906-50477653 (-)
BALB/cJ MGP_BALBcJ_G0018209
 protein coding gene Chr11:49230262-49237007 (-)
C3H/HeJ MGP_C3HHeJ_G0018020
 protein coding gene Chr11:50495769-50502514 (-)
C57BL/6NJ MGP_C57BL6NJ_G0018659
 protein coding gene Chr11:52386850-52393595 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0016311
 protein coding gene Chr11:46498836-46505647 (-)
CAST/EiJ MGP_CASTEiJ_G0017584
 protein coding gene Chr11:50494256-50500976 (-)
CBA/J MGP_CBAJ_G0017995
 protein coding gene Chr11:54842140-54848894 (-)
DBA/2J MGP_DBA2J_G0018102
 protein coding gene Chr11:48643499-48650236 (-)
FVB/NJ MGP_FVBNJ_G0018097
 protein coding gene Chr11:48349143-48355882 (-)
LP/J MGP_LPJ_G0018178
 protein coding gene Chr11:51272434-51279173 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0018120
 protein coding gene Chr11:56260041-56266800 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0018702
 protein coding gene Chr11:50568635-50575367 (-)
PWK/PhJ MGP_PWKPhJ_G0017360
 protein coding gene Chr11:49162066-49168916 (-)
SPRET/EiJ MGP_SPRETEiJ_G0017155
 protein coding gene Chr11:50302511-50309331 (-)
WSB/EiJ MGP_WSBEiJ_G0017632
 protein coding gene Chr11:50222161-50228910 (-)



Homology
more
  • Human Ortholog
    HNRNPAB, heterogeneous nuclear ribonucleoprotein A/B
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HNRNPAB, heterogeneous nuclear ribonucleoprotein A/B
  • Synonyms
    ABBP1, HNRPAB
  • Links
    NCBI Gene ID: 3182
    neXtProt AC: NX_Q99729
    UniProt: Q99729

  • Chr Location
    5q35.3; chr5:178204533-178211163 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human HNRNPAB associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 2 alleles in 2 genetic backgrounds
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit abnormal neuron differentiation, increased susceptibility to neuronal excitotoxicity and long neurites.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    34
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    873
  • Tissues
    127
  • cDNA Data
    22
  • Literature Summary
    9
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000020358 Ensembl Gene Model | MGI Sequence Detail 6748 C57BL/6J ±  kb
transcript ENSMUST00000109103 Ensembl | MGI Sequence Detail 1437 Not Applicable  
polypeptide ENSMUSP00000104731 Ensembl | MGI Sequence Detail 332 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    7 Sequences
  • Protein Ontology
    PR:000008661 heterogeneous nuclear ribonucleoprotein A/B
    (term hierarchy)
  • InterPro Domains
    IPR012956 CARG-binding factor, N-terminal
    IPR034846 hnRNPAB, RNA recognition motif 1
    IPR012677 Nucleotide-binding alpha-beta plait domain superfamily
    IPR035979 RNA-binding domain superfamily
    IPR000504 RNA recognition motif domain
  • GlyGen
    Q99020 1 site, 1 O-linked glycan (1 site)
Molecular
Reagents
less
  • All nucleic 27
    cDNA 23
    Primer pair 2
    Other 2

    Microarray probesets 10
Other
Accession IDs
less
MGI:1890913
References
more
  • Summaries
    All 60
    Developmental Gene Expression 9
    Gene Ontology 11
    Phenotypes 16
  • Earliest
    J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory