Dyrk3 MGI Mouse Gene Detail - MGI:1330300 - dual-specificity tyrosine phosphorylation regulated kinase 3

Symbol

Dyrk3
Name

dual-specificity tyrosine phosphorylation regulated kinase 3

Feature Type

protein coding gene
IDs

MGI:1330300
NCBI Gene: 226419
Alliance

gene page
Transcription Start Sites

8 TSS

Sequence Map

Chr1:131056178-131065991 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 56.90 cM
Mapping Data

1 experiment

SNPs within 2kb

375 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1330300	protein coding gene	Chr1:131055192-131066077 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0016449	protein coding gene	Chr1:134547855-134558625 (-)
A/J	MGP_AJ_G0016432	protein coding gene	Chr1:129567681-129579277 (-)
AKR/J	MGP_AKRJ_G0016397	protein coding gene	Chr1:133388745-133399527 (-)
BALB/cJ	MGP_BALBcJ_G0016392	protein coding gene	Chr1:129902333-129914816 (-)
C3H/HeJ	MGP_C3HHeJ_G0016218	protein coding gene	Chr1:133519205-133529983 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0016853	protein coding gene	Chr1:139546225-139558153 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014567	protein coding gene	Chr1:122710621-122721683 (-)
CAST/EiJ	MGP_CASTEiJ_G0015798	protein coding gene	Chr1:132523018-132534772 (-)
CBA/J	MGP_CBAJ_G0016190	protein coding gene	Chr1:144350630-144365219 (-)
DBA/2J	MGP_DBA2J_G0016297	protein coding gene	Chr1:128538855-128549754 (-)
FVB/NJ	MGP_FVBNJ_G0016296	protein coding gene	Chr1:127168260-127179085 (-)
LP/J	MGP_LPJ_G0016368	protein coding gene	Chr1:135860502-135871247 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0016321	protein coding gene	Chr1:150111202-150122749 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0016889	protein coding gene	Chr1:133149190-133161625 (-)
PWK/PhJ	MGP_PWKPhJ_G0015584	protein coding gene	Chr1:127500642-127512407 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0015371	protein coding gene	Chr1:132081246-132092189 (-)
WSB/EiJ	MGP_WSBEiJ_G0015860	protein coding gene	Chr1:133130698-133142396 (-)

Human Ortholog

DYRK3, dual specificity tyrosine phosphorylation regulated kinase 3

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

DYRK3, dual specificity tyrosine phosphorylation regulated kinase 3
Synonyms

DYRK5, hYAK3-2, RED, REDK
Links

HGNC:3094

NCBI Gene ID: 8444

neXtProt AC: NX_O43781

UniProt: O43781
Chr Location

1q32.1; chr1:206635536-206684419 (+) GRCh38

MGI Vertebrate Homology

Dyrk3 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: DYRK3
Gene Tree

Dyrk3

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Phenotype Summary

4 phenotypes from 2 alleles in 2 genetic backgrounds
1 phenotype from multigenic genotypes
13 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

24
Chemically induced (other)

2
Endonuclease-mediated

2
Gene trapped

16
Radiation induced

1
Targeted

2
Transgenic

1
Genomic Mutations

3 involving Dyrk3
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

35 strains or lines available

Mice homozygous for a null allele exhibit increased erythropoiesis in response to chemically-induced anemia.

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All GO Annotations

56
GO References

12

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

760
Tissues

32
cDNA Data

38
Literature Summary

4

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase dyrk3

ZFIN dyrk3

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All Sequences

45
RefSeq

14
UniProt

2
CCDS

CCDS15267.1

Ensembl

ENSMUSG00000016526 (Evidence)
NCBI Gene

226419

			Length	Strain/Species	Flank
genomic	226419	NCBI Gene Model \| MGI Sequence Detail	9814	C57BL/6J	± kb
transcript	NM_001418075	RefSeq \| MGI Sequence Detail	2165	C57BL/6
polypeptide	Q922Y0	UniProt \| EBI \| MGI Sequence Detail	586	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000006784 dual specificity tyrosine-phosphorylation-regulated kinase 3

(term hierarchy)
EC

2.7.12.1
InterPro Domains

IPR042521 Dual specificity tyrosine-phosphorylation-regulated kinase

IPR017441 Protein kinase, ATP binding site

IPR000719 Protein kinase domain

IPR011009 Protein kinase-like domain superfamily

IPR050494 Serine/threonine and dual-specificity kinase

IPR008271 Serine/threonine-protein kinase, active site
GlyGen

Q922Y0 1 site, 1 O-linked glycan (1 site)

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All nucleic 39

cDNA 38

Primer pair 1

Microarray probesets 3

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MGI:2385105

Summaries

All 47

Developmental Gene Expression 4

Gene Ontology 12

Phenotypes 13
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:352471 Yoshida S, et al., Primary Cilia are Required for Cell-Type Determination and Angiogenesis in Pituitary Development. Endocrinology. 2024 Jul 1;165(8)

TSS for Dyrk3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr13557	Chr1:131067033-131067076 (-)	-1,064 bp
Tssr13556	Chr1:131066005-131066063 (-)	-43 bp
Tssr13555	Chr1:131065969-131065998 (-)	7 bp
Tssr13554	Chr1:131065876-131065897 (-)	104 bp
Tssr13553	Chr1:131065863-131065868 (-)	125 bp
Tssr13552	Chr1:131064158-131064162 (-)	1,831 bp
Tssr13551	Chr1:131064066-131064078 (-)	1,919 bp
Tssr13550	Chr1:131064032-131064058 (-)	1,946 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24