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Dyrk3 Gene Detail
Summary
  • Symbol
    Dyrk3
  • Name
    dual-specificity tyrosine phosphorylation regulated kinase 3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1330300
    NCBI Gene: 226419
  • Alliance
    gene page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:131056178-131065991 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 56.90 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    375 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1330300
 protein coding gene Chr1:131055192-131066077 (-)
129S1/SvImJ MGP_129S1SvImJ_G0016449
 protein coding gene Chr1:134547855-134558625 (-)
A/J MGP_AJ_G0016432
 protein coding gene Chr1:129567681-129579277 (-)
AKR/J MGP_AKRJ_G0016397
 protein coding gene Chr1:133388745-133399527 (-)
BALB/cJ MGP_BALBcJ_G0016392
 protein coding gene Chr1:129902333-129914816 (-)
C3H/HeJ MGP_C3HHeJ_G0016218
 protein coding gene Chr1:133519205-133529983 (-)
C57BL/6NJ MGP_C57BL6NJ_G0016853
 protein coding gene Chr1:139546225-139558153 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014567
 protein coding gene Chr1:122710621-122721683 (-)
CAST/EiJ MGP_CASTEiJ_G0015798
 protein coding gene Chr1:132523018-132534772 (-)
CBA/J MGP_CBAJ_G0016190
 protein coding gene Chr1:144350630-144365219 (-)
DBA/2J MGP_DBA2J_G0016297
 protein coding gene Chr1:128538855-128549754 (-)
FVB/NJ MGP_FVBNJ_G0016296
 protein coding gene Chr1:127168260-127179085 (-)
LP/J MGP_LPJ_G0016368
 protein coding gene Chr1:135860502-135871247 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0016321
 protein coding gene Chr1:150111202-150122749 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0016889
 protein coding gene Chr1:133149190-133161625 (-)
PWK/PhJ MGP_PWKPhJ_G0015584
 protein coding gene Chr1:127500642-127512407 (-)
SPRET/EiJ MGP_SPRETEiJ_G0015371
 protein coding gene Chr1:132081246-132092189 (-)
WSB/EiJ MGP_WSBEiJ_G0015860
 protein coding gene Chr1:133130698-133142396 (-)



Homology
more
  • Human Ortholog
    DYRK3, dual specificity tyrosine phosphorylation regulated kinase 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DYRK3, dual specificity tyrosine phosphorylation regulated kinase 3
  • Synonyms
    DYRK5, hYAK3-2, RED, REDK
  • Links
    NCBI Gene ID: 8444
    neXtProt AC: NX_O43781
    UniProt: O43781

  • Chr Location
    1q32.1; chr1:206635536-206684419 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotypes from 2 alleles in 2 genetic backgrounds
    1 phenotype from multigenic genotypes
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    24
  • Chemically induced (other)
    2
  • Endonuclease-mediated
    2
  • Gene trapped
    16
  • Radiation induced
    1
  • Targeted
    2
  • Transgenic
    1
  • Genomic Mutations
    3 involving Dyrk3
  • Incidental Mutations
    Mutagenetix , APF
  • Find Mice (IMSR)
    35 strains or lines available
Mice homozygous for a null allele exhibit increased erythropoiesis in response to chemically-induced anemia.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    56
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    760
  • Tissues
    32
  • cDNA Data
    38
  • Literature Summary
    4
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 226419 NCBI Gene Model | MGI Sequence Detail 9814 C57BL/6J ±  kb
transcript NM_001418075 RefSeq | MGI Sequence Detail 2165 C57BL/6  
polypeptide Q922Y0 UniProt | EBI | MGI Sequence Detail 586 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000006784 dual specificity tyrosine-phosphorylation-regulated kinase 3
    (term hierarchy)
  • EC
    2.7.12.1
  • InterPro Domains
    IPR042521 Dual specificity tyrosine-phosphorylation-regulated kinase
    IPR017441 Protein kinase, ATP binding site
    IPR000719 Protein kinase domain
    IPR011009 Protein kinase-like domain superfamily
    IPR050494 Serine/threonine and dual-specificity kinase
    IPR008271 Serine/threonine-protein kinase, active site
  • GlyGen
    Q922Y0 1 site, 1 O-linked glycan (1 site)
Molecular
Reagents
less
  • All nucleic 39
    cDNA 38
    Primer pair 1

    Microarray probesets 3
Other
Accession IDs
less
MGI:2385105
References
more
  • Summaries
    All 47
    Developmental Gene Expression 4
    Gene Ontology 12
    Phenotypes 13
  • Earliest
    J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
  • Latest
    J:352471 Yoshida S, et al., Primary Cilia are Required for Cell-Type Determination and Angiogenesis in Pituitary Development. Endocrinology. 2024 Jul 1;165(8)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory