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Dyrk2 Gene Detail
Summary
  • Symbol
    Dyrk2
  • Name
    dual-specificity tyrosine phosphorylation regulated kinase 2
  • Synonyms
    1810038L18Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1330301
    NCBI Gene: 69181
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:118691508-118706114 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 66.75 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    332 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1330301
 protein coding gene Chr10:118691507-118725144 (-)
129S1/SvImJ MGP_129S1SvImJ_G0017768
 protein coding gene Chr10:121895687-121905238 (-)
A/J MGP_AJ_G0017743
 protein coding gene Chr10:117115010-117124534 (-)
AKR/J MGP_AKRJ_G0017706
 protein coding gene Chr10:120599426-120608946 (-)
BALB/cJ MGP_BALBcJ_G0017707
 protein coding gene Chr10:117496450-117505974 (-)
C3H/HeJ MGP_C3HHeJ_G0017531
 protein coding gene Chr10:120774046-120783600 (-)
C57BL/6NJ MGP_C57BL6NJ_G0018162
 protein coding gene Chr10:126034212-126043763 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015843
 protein coding gene Chr10:111507177-111516718 (-)
CAST/EiJ MGP_CASTEiJ_G0017092
 protein coding gene Chr10:121093957-121103645 (-)
CBA/J MGP_CBAJ_G0017500
 protein coding gene Chr10:131126294-131141386 (-)
DBA/2J MGP_DBA2J_G0017606
 protein coding gene Chr10:116225284-116234501 (-)
FVB/NJ MGP_FVBNJ_G0017601
 protein coding gene Chr10:115232504-115243565 (-)
LP/J MGP_LPJ_G0017680
 protein coding gene Chr10:122453831-122464570 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0017630
 protein coding gene Chr10:133856838-133866365 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0018203
 protein coding gene Chr10:120625274-120634794 (-)
PWK/PhJ MGP_PWKPhJ_G0016876
 protein coding gene Chr10:116325153-116334781 (-)
SPRET/EiJ MGP_SPRETEiJ_G0016667
 protein coding gene Chr10:119483088-119492609 (-)
WSB/EiJ MGP_WSBEiJ_G0017152
 protein coding gene Chr10:120811825-120821344 (-)



Homology
more
  • Human Ortholog
    DYRK2, dual specificity tyrosine phosphorylation regulated kinase 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DYRK2, dual specificity tyrosine phosphorylation regulated kinase 2
  • Links
    NCBI Gene ID: 8445
    neXtProt AC: NX_Q92630
    UniProt: Q92630

  • Chr Location
    12q15; chr12:67648338-67665406 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    13 phenotypes from 2 alleles in 2 genetic backgrounds
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous knockout affects ciliogenesis, which affects bone development and leads to perinatal lethality.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    43
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    767
  • Tissues
    29
  • cDNA Data
    5
  • Literature Summary
    7
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000028630 Ensembl Gene Model | MGI Sequence Detail 14607 C57BL/6J ±  kb
    transcript ENSMUST00000004281 Ensembl | MGI Sequence Detail 6129 Not Applicable  
    polypeptide ENSMUSP00000004281 Ensembl | MGI Sequence Detail 599 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      1 Sequence
    • Protein Ontology
      PR:000006783 dual specificity tyrosine-phosphorylation-regulated kinase 2
      (term hierarchy)
    • EC
      2.7.12.1
    • InterPro Domains
      IPR042521 Dual specificity tyrosine-phosphorylation-regulated kinase
      IPR017441 Protein kinase, ATP binding site
      IPR000719 Protein kinase domain
      IPR011009 Protein kinase-like domain superfamily
      IPR050494 Serine/threonine and dual-specificity kinase
      IPR008271 Serine/threonine-protein kinase, active site
    Molecular
    Reagents
    less
    • All nucleic 10
      Genomic 2
      cDNA 7
      Primer pair 1

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGI:1916431
    References
    more
    • Summaries
      All 45
      Developmental Gene Expression 7
      Gene Ontology 9
      Phenotypes 14
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:352471 Yoshida S, et al., Primary Cilia are Required for Cell-Type Determination and Angiogenesis in Pituitary Development. Endocrinology. 2024 Jul 1;165(8)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory