Dyrk1b MGI Mouse Gene Detail - MGI:1330302 - dual-specificity tyrosine phosphorylation regulated kinase 1b

Symbol

Dyrk1b
Name

dual-specificity tyrosine phosphorylation regulated kinase 1b
Synonyms

Mirk

Feature Type

protein coding gene
IDs

MGI:1330302
NCBI Gene: 13549
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr7:27878894-27886719 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 7, 16.67 cM
Mapping Data

1 experiment

SNPs within 2kb

141 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1330302	protein coding gene	Chr7:27878880-27896896 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0031933	protein coding gene	Chr7:26948550-26956375 (+)
A/J	MGP_AJ_G0031912	protein coding gene	Chr7:26296052-26303877 (+)
AKR/J	MGP_AKRJ_G0031843	protein coding gene	Chr7:26970328-26978153 (+)
BALB/cJ	MGP_BALBcJ_G0031918	protein coding gene	Chr7:26452110-26460023 (+)
C3H/HeJ	MGP_C3HHeJ_G0031640	protein coding gene	Chr7:27351260-27359065 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0032383	protein coding gene	Chr7:27819683-27827508 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0029435	protein coding gene	Chr7:27394494-27402392 (+)
CAST/EiJ	MGP_CASTEiJ_G0030975	protein coding gene	Chr7:20643552-20651367 (+)
CBA/J	MGP_CBAJ_G0031603	protein coding gene	Chr7:29071217-29079022 (+)
DBA/2J	MGP_DBA2J_G0031756	protein coding gene	Chr7:26059794-26067619 (+)
FVB/NJ	MGP_FVBNJ_G0031713	protein coding gene	Chr7:26133744-26141561 (+)
LP/J	MGP_LPJ_G0031837	protein coding gene	Chr7:27281405-27289230 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0031748	protein coding gene	Chr7:28574574-28582614 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0032413	protein coding gene	Chr7:26445502-26453327 (+)
PWK/PhJ	MGP_PWKPhJ_G0030698	protein coding gene	Chr7:21069094-21077018 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0030533	protein coding gene	Chr7:17437936-17445699 (+)
WSB/EiJ	MGP_WSBEiJ_G0031082	protein coding gene	Chr7:26781843-26789660 (+)

Human Ortholog

DYRK1B, dual specificity tyrosine phosphorylation regulated kinase 1B

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

DYRK1B, dual specificity tyrosine phosphorylation regulated kinase 1B
Synonyms

AOMS3, MIRK
Links

HGNC:3092

NCBI Gene ID: 9149

neXtProt AC: NX_Q9Y463

UniProt: Q9Y463
Chr Location

19q13.2; chr19:39825350-39834201 (-) GRCh38

MGI Vertebrate Homology

Dyrk1b stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: DYRK1B
Gene Tree

Dyrk1b

Diseases

1 with human DYRK1B associations

				Human Disease	Mouse Models
				abdominal obesity-metabolic syndrome 3 IDs abdominal obesity-metabolic syndrome 3 DOID:0060612 OMIM:615812

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

27 phenotypes from 3 alleles in 3 genetic backgrounds
13 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

9
Endonuclease-mediated

3
Gene trapped

1
Targeted

4
Transgenic

1
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

31 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null mutation display decreased response of the heart to induced stress.

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All GO Annotations

26
GO References

10

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

714
Tissues

1
cDNA Data

18
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

49
RefSeq

16
UniProt

1
CCDS

CCDS21037.1, CCDS57532.1, CCDS85251.1

Ensembl

ENSMUSG00000002409 (Evidence)
NCBI Gene

13549

			Length	Strain/Species	Flank
genomic	ENSMUSG00000002409	Ensembl Gene Model \| MGI Sequence Detail	7826	C57BL/6J	± kb
transcript	ENSMUST00000172467	Ensembl \| MGI Sequence Detail	2523	Not Applicable
polypeptide	ENSMUSP00000133431	Ensembl \| MGI Sequence Detail	689	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000006782 dual specificity tyrosine-phosphorylation-regulated kinase 1B

(term hierarchy)
EC

2.7.12.1
InterPro Domains

IPR044131 Dual specificity tyrosine-phosphorylation-regulated kinase 1A/1B, catalytic domain

IPR017441 Protein kinase, ATP binding site

IPR000719 Protein kinase domain

IPR011009 Protein kinase-like domain superfamily

IPR050494 Serine/threonine and dual-specificity kinase

IPR008271 Serine/threonine-protein kinase, active site
GlyGen

Q9Z188 2 sites, 1 O-linked glycan (2 sites)

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All nucleic 18

cDNA 18

Microarray probesets 3

Summaries

All 43

Developmental Gene Expression 2

Gene Ontology 10

Phenotypes 13
Earliest

J:50326 Becker W, et al., Sequence characteristics, subcellular localization, and substrate specificity of DYRK-related kinases, a novel family of dual specificity protein kinases. J Biol Chem. 1998 Oct 2;273(40):25893-902
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Dyrk1b:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr65447	Chr7:27878912-27878960 (+)	42 bp
Tssr65448	Chr7:27879418-27879453 (+)	542 bp
Tssr65449	Chr7:27879475-27879480 (+)	584 bp
Tssr65450	Chr7:27879599-27879644 (+)	728 bp
Tssr65451	Chr7:27879651-27879691 (+)	777 bp
Tssr65452	Chr7:27879697-27879714 (+)	812 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24