Sprr2e MGI Mouse Gene Detail - MGI:1330346 - small proline-rich protein 2E

Symbol

Sprr2e
Name

small proline-rich protein 2E

Feature Type

protein coding gene
IDs

MGI:1330346
NCBI Gene: 20759
Alliance

gene page
Transcription Start Sites

1 TSS

Sequence Map

Chr3:92259450-92260756 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 3, 40.14 cM
Mapping Data

3 experiments

SNPs within 2kb

158 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1330346	protein coding gene	Chr3:92259450-92260757 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0027490	protein coding gene	Chr3:92792772-92794078 (+)
A/J	MGP_AJ_G0027457	protein coding gene	Chr3:89875414-89876720 (+)
AKR/J	MGP_AKRJ_G0027422	protein coding gene	Chr3:91977623-91978929 (+)
BALB/cJ	MGP_BALBcJ_G0027466	protein coding gene	Chr3:89686426-89687732 (+)
C3H/HeJ	MGP_C3HHeJ_G0027205	protein coding gene	Chr3:92200256-92201562 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0027909	protein coding gene	Chr3:96329953-96331259 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0025260	protein coding gene	Chr3:86517943-86519266 (+)
CAST/EiJ	MGP_CASTEiJ_G0026653	protein coding gene	Chr3:91608196-91609502 (+)
CBA/J	MGP_CBAJ_G0027180	protein coding gene	Chr3:99625880-99627186 (+)
DBA/2J	MGP_DBA2J_G0027317	protein coding gene	Chr3:89195224-89196530 (+)
FVB/NJ	MGP_FVBNJ_G0027285	protein coding gene	Chr3:87361609-87362915 (+)
LP/J	MGP_LPJ_G0027426	protein coding gene	Chr3:94014660-94015966 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0027309	protein coding gene	Chr3:105871698-105873005 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0027968	protein coding gene	Chr3:91706524-91707830 (+)
PWK/PhJ	MGP_PWKPhJ_G0026386	protein coding gene	Chr3:89083196-89084610 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0026205	protein coding gene	Chr3:90031742-90033048 (+)
WSB/EiJ	MGP_WSBEiJ_G0026735	protein coding gene	Chr3:92100417-92101724 (+)

Human Ortholog

SPRR2A, small proline rich protein 2A

Vertebrate Orthologs

7

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SPRR2A, small proline rich protein 2A
Links

HGNC:11261

NCBI Gene ID: 6700

neXtProt AC: NX_P35326

UniProt: P35326
Chr Location

1q21.3; chr1:153056120-153057512 (-) GRCh38

Human Ortholog

SPRR2B, small proline rich protein 2B
Links

HGNC:11262

NCBI Gene ID: 6701

neXtProt AC: NX_P35325

UniProt: P35325
Chr Location

1q21.3; chr1:153070226-153087799 (-) GRCh38

Human Ortholog

SPRR2D, small proline rich protein 2D
Links

HGNC:11264

NCBI Gene ID: 6703

neXtProt AC: NX_P22532

UniProt: P22532
Chr Location

1q21.3; chr1:153039732-153041931 (-) GRCh38

Human Ortholog

SPRR2E, small proline rich protein 2E
Links

HGNC:11265

NCBI Gene ID: 6704

neXtProt AC: NX_P22531

UniProt: P22531
Chr Location

1q21.3; chr1:153093135-153106184 (-) GRCh38

Human Ortholog

SPRR2F, small proline rich protein 2F
Links

HGNC:11266

NCBI Gene ID: 6705

neXtProt AC: NX_Q96RM1

UniProt: Q96RM1
Chr Location

1q21.3; chr1:153112121-153119468 (-) GRCh38

MGI Vertebrate Homology

Sprr2e stringent orthology
5 human;1 mouse;2 rat
HCOP

vertebrate homology predictions: SPRR2A, SPRR2B, SPRR2D, SPRR2E, SPRR2F
Gene Tree

Sprr2e

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References

1 with disease annotations

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Phenotype Summary

4 phenotype references

All Mutations and Alleles

2
Chemically induced (other)

1
Radiation induced

1
Genomic Mutations

2 involving Sprr2e
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

4 strains or lines available

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All GO Annotations

14
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

3
Literature Summary

3

Tissue x Stage Matrix

Other Mouse Links

GEO

Expression Atlas

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All Sequences

30
RefSeq

2
UniProt

2
CCDS

CCDS57225.1

Ensembl

ENSMUSG00000055030 (Evidence)
NCBI Gene

20759

			Length	Strain/Species	Flank
genomic	ENSMUSG00000055030	Ensembl Gene Model \| MGI Sequence Detail	1307	C57BL/6J	± kb
transcript	ENSMUST00000068399	Ensembl \| MGI Sequence Detail	647	Not Applicable
polypeptide	ENSMUSP00000064652	Ensembl \| MGI Sequence Detail	76	Not Applicable

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UniProt

2 Sequences
InterPro Domains

IPR029142 Small proline-rich protein 2

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All nucleic 7

Genomic 4

cDNA 3

Microarray probesets 2

Summaries

All 23

Developmental Gene Expression 3

Diseases 1

Gene Ontology 5

Phenotypes 4
Earliest

J:113697 Gibbs S, et al., Molecular characterization and evolution of the SPRR family of keratinocyte differentiation markers encoding small proline-rich proteins. Genomics. 1993 Jun;16(3):630-7
Latest

J:302829 Lu J, et al., Mouse models for human hyperuricaemia: a critical review. Nat Rev Rheumatol. 2019 Jul;15(7):413-426

TSS for Sprr2e:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr30284	Chr3:92259448-92259451 (+)	0 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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