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Sprr2d Gene Detail
Summary
  • Symbol
    Sprr2d
  • Name
    small proline-rich protein 2D
  • Feature Type
    protein coding gene
  • IDs
    MGI:1330347
    NCBI Gene: 20758
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:92246447-92248180 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 40.14 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    170 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1330347
 protein coding gene Chr3:92246447-92248187 (+)
129S1/SvImJ MGP_129S1SvImJ_G0027489
 protein coding gene Chr3:92774653-92776374 (+)
A/J MGP_AJ_G0027456
 protein coding gene Chr3:89862535-89864268 (+)
AKR/J MGP_AKRJ_G0027421
 protein coding gene Chr3:91965734-91967455 (+)
BALB/cJ MGP_BALBcJ_G0027465
 protein coding gene Chr3:89671494-89673245 (+)
C3H/HeJ MGP_C3HHeJ_G0027204
 protein coding gene Chr3:92186912-92188645 (+)
C57BL/6NJ MGP_C57BL6NJ_G0027908
 protein coding gene Chr3:96316200-96317933 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0025259
 protein coding gene Chr3:86500532-86502345 (+)
CAST/EiJ MGP_CASTEiJ_G0026652
 protein coding gene Chr3:91589945-91597996 (+)
CBA/J MGP_CBAJ_G0027179
 protein coding gene Chr3:99608382-99610221 (+)
DBA/2J MGP_DBA2J_G0027316
 protein coding gene Chr3:89178822-89180553 (+)
FVB/NJ MGP_FVBNJ_G0027284
 protein coding gene Chr3:87348023-87349756 (+)
LP/J MGP_LPJ_G0027425
 protein coding gene Chr3:94000965-94002698 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0027308
 protein coding gene Chr3:105859130-105859741 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0027967
 protein coding gene Chr3:91683486-91685246 (+)
PWK/PhJ MGP_PWKPhJ_G0026385
 protein coding gene Chr3:89065619-89067376 (+)
SPRET/EiJ MGP_SPRETEiJ_G0026204
 protein coding gene Chr3:90019062-90020760 (+)
WSB/EiJ MGP_WSBEiJ_G0026734
 protein coding gene Chr3:92086772-92088530 (+)



Homology
more
  • Human Ortholog
    SPRR2A, small proline rich protein 2A
  • Vertebrate Orthologs
    7
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SPRR2A, small proline rich protein 2A
  • Links
    NCBI Gene ID: 6700
    neXtProt AC: NX_P35326
    UniProt: P35326

  • Chr Location
    1q21.3; chr1:153056120-153057512 (-)  GRCh38
  • Human Ortholog
    SPRR2B, small proline rich protein 2B
  • Links
    NCBI Gene ID: 6701
    neXtProt AC: NX_P35325
    UniProt: P35325

  • Chr Location
    1q21.3; chr1:153070226-153087799 (-)  GRCh38
  • Human Ortholog
    SPRR2D, small proline rich protein 2D
  • Links
    NCBI Gene ID: 6703
    neXtProt AC: NX_P22532
    UniProt: P22532

  • Chr Location
    1q21.3; chr1:153039732-153041931 (-)  GRCh38
  • Human Ortholog
    SPRR2E, small proline rich protein 2E
  • Links
    NCBI Gene ID: 6704
    neXtProt AC: NX_P22531
    UniProt: P22531

  • Chr Location
    1q21.3; chr1:153093135-153106184 (-)  GRCh38
  • Human Ortholog
    SPRR2F, small proline rich protein 2F
  • Links
    NCBI Gene ID: 6705
    neXtProt AC: NX_Q96RM1
    UniProt: Q96RM1

  • Chr Location
    1q21.3; chr1:153112121-153119468 (-)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotype references
  • All Mutations and Alleles
    4
  • Chemically induced (other)
    1
  • Radiation induced
    1
  • Targeted
    2
  • Genomic Mutations
    2 involving Sprr2d
  • Find Mice (IMSR)
    17 strains or lines available
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    16
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    827
  • Tissues
    28
  • cDNA Data
    5
  • Literature Summary
    14
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000042212 Ensembl Gene Model | MGI Sequence Detail 1734 C57BL/6J ±  kb
transcript ENSMUST00000047477 Ensembl | MGI Sequence Detail 681 Not Applicable  
polypeptide ENSMUSP00000039821 Ensembl | MGI Sequence Detail 85 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    1 Sequence
  • InterPro Domains
    IPR029142 Small proline-rich protein 2
Molecular
Reagents
less
  • All nucleic 19
    Genomic 6
    cDNA 5
    Primer pair 7
    Other 1

    Microarray probesets 3
References
more
  • Summaries
    All 42
    Developmental Gene Expression 14
    Diseases 1
    Gene Ontology 5
    Phenotypes 7
  • Earliest
    J:113697 Gibbs S, et al., Molecular characterization and evolution of the SPRR family of keratinocyte differentiation markers encoding small proline-rich proteins. Genomics. 1993 Jun;16(3):630-7
  • Latest
    J:335426 Butera A, et al., ZFP750 affects the cutaneous barrier through regulating lipid metabolism. Sci Adv. 2023 Apr 28;9(17):eadg5423
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory