Hsd17b7 MGI Mouse Gene Detail - MGI:1330808 - hydroxysteroid (17-beta) dehydrogenase 7

Symbol

Hsd17b7
Name

hydroxysteroid (17-beta) dehydrogenase 7
Synonyms

ERG27

Feature Type

protein coding gene
IDs

MGI:1330808
NCBI Gene: 15490
Alliance

gene page
Transcription Start Sites

1 TSS

Sequence Map

Chr1:169777109-169796757 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 76.84 cM
Mapping Data

2 experiments

SNPs within 2kb

785 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1330808	protein coding gene	Chr1:169777104-169796810 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0016723	protein coding gene	Chr1:175639154-175658882 (-)
A/J	MGP_AJ_G0016703	protein coding gene	Chr1:168452734-168472461 (-)
AKR/J	MGP_AKRJ_G0016669	protein coding gene	Chr1:173532144-173551850 (-)
BALB/cJ	MGP_BALBcJ_G0016664	protein coding gene	Chr1:168948383-168968089 (-)
C3H/HeJ	MGP_C3HHeJ_G0016488	protein coding gene	Chr1:173783267-173802995 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0017125	protein coding gene	Chr1:181451385-181471091 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014834	protein coding gene	Chr1:160221211-160240326 (-)
CAST/EiJ	MGP_CASTEiJ_G0016068	protein coding gene	Chr1:173402606-173424034 (-)
CBA/J	MGP_CBAJ_G0016463	protein coding gene	Chr1:187906895-187926601 (-)
DBA/2J	MGP_DBA2J_G0016569	protein coding gene	Chr1:167328934-167348640 (-)
FVB/NJ	MGP_FVBNJ_G0016567	protein coding gene	Chr1:165704547-165724268 (-)
LP/J	MGP_LPJ_G0016640	protein coding gene	Chr1:176696461-176716185 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0016592	protein coding gene	Chr1:195239819-195260757 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0017162	protein coding gene	Chr1:173419285-173439025 (-)
PWK/PhJ	MGP_PWKPhJ_G0015854	protein coding gene	Chr1:166557029-166576807 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0015640	protein coding gene	Chr1:172182924-172202770 (-)
WSB/EiJ	MGP_WSBEiJ_G0016130	protein coding gene	Chr1:173534539-173554259 (-)

Human Ortholog

HSD17B7, hydroxysteroid 17-beta dehydrogenase 7

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

HSD17B7, hydroxysteroid 17-beta dehydrogenase 7
Synonyms

PRAP, SDR37C1
Links

HGNC:5215

NCBI Gene ID: 51478

neXtProt AC: NX_P56937

UniProt: P56937
Chr Location

1q23.3; chr1:162790702-162812823 (+) GRCh38

MGI Vertebrate Homology

Hsd17b7 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: HSD17B7
Gene Tree

Hsd17b7

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Phenotype Summary

27 phenotypes from 3 alleles in 3 genetic backgrounds
13 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

9
Chemically induced (ENU)

1
Chemically induced (other)

2
Endonuclease-mediated

1
Gene trapped

1
Targeted

4
Genomic Mutations

2 involving Hsd17b7
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

18 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a targeted allele exhibit embryonic lethality, abnormal brain development, abnormal branchial arches, pericardial effusion, and abnormal cardiovascular development.

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All GO Annotations

29
GO References

9

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

862
Tissues

133
cDNA Data

52
Literature Summary

9

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase hsd17b7

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All Sequences

51
RefSeq

8
UniProt

2
CCDS

CCDS35766.1

Ensembl

ENSMUSG00000026675 (Evidence)
NCBI Gene

15490

			Length	Strain/Species	Flank
genomic	15490	NCBI Gene Model \| MGI Sequence Detail	19649	C57BL/6J	± kb
transcript	NM_010476	RefSeq \| MGI Sequence Detail	4554	C57BL/6
polypeptide	O88736	UniProt \| EBI \| MGI Sequence Detail	334	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000008783 3-keto-steroid reductase/17-beta-hydroxysteroid dehydrogenase 7

(term hierarchy)
EC

1.1.1.210, 1.1.1.270, 1.1.1.62
InterPro Domains

IPR042829 3-keto-steroid reductase

IPR052834 3-Keto-Steroid Reductase/17-beta-Hydroxysteroid Dehydrogenase

IPR036291 NAD(P)-binding domain superfamily

IPR002347 Short-chain dehydrogenase/reductase SDR
GlyGen

O88736 4 sites

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All nucleic 55

cDNA 52

Primer pair 3

Microarray probesets 8

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MGI:2138189

Summaries

All 47

Developmental Gene Expression 9

Gene Ontology 9

Phenotypes 13
Earliest

J:48295 Nokelainen P, et al., Expression cloning of a novel estrogenic mouse 17 beta-hydroxysteroid dehydrogenase/17-ketosteroid reductase (m17HSD7), previously described as a prolactin receptor-associated protein (PRAP) in rat. Mol Endocrinol. 1998 Jul;12(7):1048-59
Latest

J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;

TSS for Hsd17b7:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr14894	Chr1:169796712-169796787 (-)	7 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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