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Qsox1 Gene Detail
Summary
  • Symbol
    Qsox1
  • Name
    quiescin Q6 sulfhydryl oxidase 1
  • Synonyms
    1300003H02Rik, b2b2673Clo, Qscn6, QSOX
  • Feature Type
    protein coding gene
  • IDs
    MGI:1330818
    NCBI Gene: 104009
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:155653901-155688645 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 67.64 cM, cytoband G3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1063 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1330818
 protein coding gene Chr1:155651775-155688645 (-)
129S1/SvImJ MGP_129S1SvImJ_G0016616
 protein coding gene Chr1:160716564-160753529 (-)
A/J MGP_AJ_G0016597
 protein coding gene Chr1:154274251-154311198 (-)
AKR/J MGP_AKRJ_G0016563
 protein coding gene Chr1:159002714-159039704 (-)
BALB/cJ MGP_BALBcJ_G0016558
 protein coding gene Chr1:154772044-154809593 (-)
C3H/HeJ MGP_C3HHeJ_G0016382
 protein coding gene Chr1:159128172-159165160 (-)
C57BL/6NJ MGP_C57BL6NJ_G0017019
 protein coding gene Chr1:166234473-166271323 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014728
 protein coding gene Chr1:146487652-146525502 (-)
CAST/EiJ MGP_CASTEiJ_G0015962
 protein coding gene Chr1:158660299-158696905 (-)
CBA/J MGP_CBAJ_G0016357
 protein coding gene Chr1:172087465-172124431 (-)
DBA/2J MGP_DBA2J_G0016463
 protein coding gene Chr1:153236524-153275801 (-)
FVB/NJ MGP_FVBNJ_G0016461
 protein coding gene Chr1:151701135-151738110 (-)
LP/J MGP_LPJ_G0016534
 protein coding gene Chr1:161863661-161902797 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0016486
 protein coding gene Chr1:179679873-179716859 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0017055
 protein coding gene Chr1:158804056-158842502 (-)
PWK/PhJ MGP_PWKPhJ_G0015748
 protein coding gene Chr1:152307885-152345002 (-)
SPRET/EiJ MGP_SPRETEiJ_G0015535
 protein coding gene Chr1:157546834-157583336 (-)
WSB/EiJ MGP_WSBEiJ_G0016024
 protein coding gene Chr1:158891646-158930188 (-)



Homology
more
  • Human Ortholog
    QSOX1, quiescin sulfhydryl oxidase 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    QSOX1, quiescin sulfhydryl oxidase 1
  • Synonyms
    Q6, QSCN6
  • Links
    NCBI Gene ID: 5768
    neXtProt AC: NX_O00391
    UniProt: O00391

  • Chr Location
    1q25.2; chr1:180154869-180204030 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Qsox1 mouse models

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    20 phenotypes from 2 alleles in 2 genetic backgrounds
    10 images
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for an ENU-induced mutation show cardiovascular phenotypes including persistent truncus arteriosus, atriventricular septal defects and vascular ring, as well as eye defects, short snout, micrognathia, cleft palate, tracheosophageal fistula, polydactyly and spleen hypoplasia.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    32
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    898
  • Tissues
    136
  • cDNA Data
    134
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 104009 NCBI Gene Model | MGI Sequence Detail 34745 C57BL/6J ±  kb
    transcript NM_001024945 RefSeq | MGI Sequence Detail 3399 C57BL/6  
    polypeptide Q8BND5 UniProt | EBI | MGI Sequence Detail 748 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 134
      cDNA 134

      Microarray probesets 8
    Other
    Accession IDs
    less
    MGI:1914133, MGI:5615572
    References
    more
    • Summaries
      All 48
      Developmental Gene Expression 3
      Diseases 1
      Gene Ontology 7
      Phenotypes 14
    • Earliest
      J:52083 Coppock DL, et al., The quiescin Q6 gene (QSCN6) is a fusion of two ancient gene families: thioredoxin and ERV1. Genomics. 1998 Dec 15;54(3):460-8
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory