Rasal1 MGI Mouse Gene Detail - MGI:1330842 - RAS protein activator like 1 (GAP1 like)

Symbol

Rasal1
Name

RAS protein activator like 1 (GAP1 like)
Synonyms

MRASAL

Feature Type

protein coding gene
IDs

MGI:1330842
NCBI Gene: 19415
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr5:120786877-120817662 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 5, 60.63 cM
Mapping Data

1 experiment

SNPs within 2kb

829 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1330842	protein coding gene	Chr5:120786105-120817662 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0030011	protein coding gene	Chr5:124047025-124080295 (+)
A/J	MGP_AJ_G0029975	protein coding gene	Chr5:118895551-118926127 (+)
AKR/J	MGP_AKRJ_G0029914	protein coding gene	Chr5:122735179-122766237 (+)
BALB/cJ	MGP_BALBcJ_G0029986	protein coding gene	Chr5:120312052-120344354 (+)
C3H/HeJ	MGP_C3HHeJ_G0029706	protein coding gene	Chr5:123269877-123306571 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0030441	protein coding gene	Chr5:128690113-128720874 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0027667	protein coding gene	Chr5:113603350-113634442 (+)
CAST/EiJ	MGP_CASTEiJ_G0029115	protein coding gene	Chr5:122398520-122433884 (+)
CBA/J	MGP_CBAJ_G0029674	protein coding gene	Chr5:133681476-133724103 (+)
DBA/2J	MGP_DBA2J_G0029824	protein coding gene	Chr5:118980902-119011511 (+)
FVB/NJ	MGP_FVBNJ_G0029780	protein coding gene	Chr5:117909771-117942646 (+)
LP/J	MGP_LPJ_G0029912	protein coding gene	Chr5:124494526-124527646 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0029811	protein coding gene	Chr5:137647835-137682037 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0030482	protein coding gene	Chr5:122316096-122347216 (+)
PWK/PhJ	MGP_PWKPhJ_G0028828	protein coding gene	Chr5:117741963-117774336 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0028667	protein coding gene	Chr5:119974446-120006984 (+)
WSB/EiJ	MGP_WSBEiJ_G0029190	protein coding gene	Chr5:122904005-122937136 (+)

Human Ortholog

RASAL1, RAS protein activator like 1

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

RASAL1, RAS protein activator like 1
Synonyms

RASAL
Links

HGNC:9873

NCBI Gene ID: 8437

neXtProt AC: NX_O95294

UniProt: O95294
Chr Location

12q24.13; chr12:113098819-113136756 (-) GRCh38

MGI Vertebrate Homology

Rasal1 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: RASAL1
Gene Tree

Rasal1

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
12 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Chemically induced (other)

1
Endonuclease-mediated

2
Radiation induced

1
Targeted

3
Genomic Mutations

2 involving Rasal1
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

50 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a hypomorphic allele exhibit increased kidney fibrosis upon challenge with unilateral ureteral obstruction.

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All GO Annotations

12
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

714
Tissues

1
cDNA Data

22
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

Xenbase rasal1

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All Sequences

61
RefSeq

26
UniProt

3
CCDS

CCDS19623.1

Ensembl

ENSMUSG00000029602 (Evidence)
NCBI Gene

19415

			Length	Strain/Species	Flank
genomic	ENSMUSG00000029602	Ensembl Gene Model \| MGI Sequence Detail	30786	C57BL/6J	± kb
transcript	ENSMUST00000031606	Ensembl \| MGI Sequence Detail	3212	Not Applicable
polypeptide	ENSMUSP00000031606	Ensembl \| MGI Sequence Detail	799	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000013747 RasGAP-activating-like protein 1

(term hierarchy)
InterPro Domains

IPR000008 C2 domain

IPR035892 C2 domain superfamily

IPR011993 PH-like domain superfamily

IPR001849 Pleckstrin homology domain

IPR037776 RASAL, RasGAP domain

IPR001936 Ras GTPase-activating domain

IPR039360 Ras GTPase-activating protein

IPR023152 Ras GTPase-activating protein, conserved site

IPR008936 Rho GTPase activation protein

IPR052455 Tricalbin domain-containing protein

IPR001562 Zinc finger, Btk motif
GlyGen

Q9Z268 2 sites, 2 N-linked glycans (2 sites)

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All nucleic 29

Genomic 7

cDNA 22

Microarray probesets 3

Summaries

All 38

Developmental Gene Expression 2

Gene Ontology 4

Phenotypes 12
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:359420 Shen X, et al., The genetic duet of concurrent RASAL1 and PTEN alterations promotes cancer aggressiveness by cooperatively activating the PI3K-AKT pathway. Mol Oncol. 2024 Jul 20;

TSS for Rasal1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr48531	Chr5:120787278-120787324 (+)	424 bp
Tssr48532	Chr5:120787401-120787412 (+)	530 bp
Tssr48533	Chr5:120793450-120793454 (+)	6,575 bp
Tssr48534	Chr5:120816613-120816621 (+)	29,740 bp
Tssr48535	Chr5:120816634-120816641 (+)	29,761 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/17/2024 MGI 6.24