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Atp8a1 Gene Detail
Summary
  • Symbol
    Atp8a1
  • Name
    ATPase phospholipid transporting 8A1
  • Synonyms
    Atp3a2, B230107D19Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1330848
    NCBI Gene: 11980
  • Alliance
    gene page
  • Transcription Start Sites
    17 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:67775483-68004777 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 36.15 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    6304 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1330848
 protein coding gene Chr5:67775482-68004822 (-)
129S1/SvImJ MGP_129S1SvImJ_G0029597
 protein coding gene Chr5:67401905-67637181 (-)
A/J MGP_AJ_G0029565
 protein coding gene Chr5:64879915-65110742 (-)
AKR/J MGP_AKRJ_G0029513
 protein coding gene Chr5:66956337-67192857 (-)
BALB/cJ MGP_BALBcJ_G0029574
 protein coding gene Chr5:65550749-65776151 (-)
C3H/HeJ MGP_C3HHeJ_G0029297
 protein coding gene Chr5:67271678-67516841 (-)
C57BL/6NJ MGP_C57BL6NJ_G0030028
 protein coding gene Chr5:70181251-70424157 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027268
 protein coding gene Chr5:60920884-61148032 (-)
CAST/EiJ MGP_CASTEiJ_G0028705
 protein coding gene Chr5:66476784-66708387 (-)
CBA/J MGP_CBAJ_G0029266
 protein coding gene Chr5:72432642-72682545 (-)
DBA/2J MGP_DBA2J_G0029412
 protein coding gene Chr5:64889124-65114587 (-)
FVB/NJ MGP_FVBNJ_G0029372
 protein coding gene Chr5:64061806-64287742 (-)
LP/J MGP_LPJ_G0029497
 protein coding gene Chr5:67895160-68131041 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0029400
 protein coding gene Chr5:75235742-75481360 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0030061
 protein coding gene Chr5:66622656-66862580 (-)
PWK/PhJ MGP_PWKPhJ_G0028429
 protein coding gene Chr5:63932661-64158343 (-)
SPRET/EiJ MGP_SPRETEiJ_G0028263
 protein coding gene Chr5:65956527-66187319 (-)
WSB/EiJ MGP_WSBEiJ_G0028785
 protein coding gene Chr5:66852584-67085346 (-)



Homology
more
  • Human Ortholog
    ATP8A1, ATPase phospholipid transporting 8A1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ATP8A1, ATPase phospholipid transporting 8A1
  • Synonyms
    ATPASEII, ATPIA, ATPP2
  • Links
    NCBI Gene ID: 10396
    neXtProt AC: NX_Q9Y2Q0
    UniProt: Q9Y2Q0

  • Chr Location
    4p13; chr4:42408373-42657121 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 2 alleles in 2 genetic backgrounds
    30 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutant mice are viable, fertile and phenotypically normal.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    47
  • GO References
    16
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1113
  • Tissues
    245
  • cDNA Data
    122
  • Literature Summary
    7
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000037685 Ensembl Gene Model | MGI Sequence Detail 229295 C57BL/6J ±  kb
    transcript ENSMUST00000072971 Ensembl | MGI Sequence Detail 7154 Not Applicable  
    polypeptide ENSMUSP00000072738 Ensembl | MGI Sequence Detail 1164 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 125
      cDNA 122
      Primer pair 3

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGI:2140919, MGI:2141001, MGI:2141248, MGI:2141251, MGI:2444604
    References
    more
    • Summaries
      All 77
      Developmental Gene Expression 7
      Gene Ontology 16
      Phenotypes 30
    • Earliest
      J:5021 Batchelor AL, et al., A comparison of the mutagenic effectiveness of chronic neutron- and gamma-irradiation of mouse spermatogonia. Mutat Res. 1966 Jun;3(3):218-29
    • Latest
      J:345844 Guo Y, et al., Docking protein 6 (DOK6) selectively docks the neurotrophic signaling transduction to restrain peripheral neuropathy. Signal Transduct Target Ther. 2024 Feb 14;9(1):32
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory