Soat2 MGI Mouse Gene Detail - MGI:1332226 - sterol O-acyltransferase 2

Symbol

Soat2
Name

sterol O-acyltransferase 2
Synonyms

ACAT2, D15Wsu97e

Feature Type

protein coding gene
IDs

MGI:1332226
NCBI Gene: 223920
Alliance

gene page
Transcription Start Sites

9 TSS

Sequence Map

Chr15:102058961-102071904 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 15, 57.33 cM
Mapping Data

5 experiments

SNPs within 2kb

425 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1332226	protein coding gene	Chr15:102058853-102071904 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0022401	protein coding gene	Chr15:104301790-104317070 (+)
A/J	MGP_AJ_G0022363	protein coding gene	Chr15:100209938-100222836 (+)
AKR/J	MGP_AKRJ_G0022338	protein coding gene	Chr15:103240300-103253134 (+)
BALB/cJ	MGP_BALBcJ_G0022367	protein coding gene	Chr15:100253221-100266210 (+)
C3H/HeJ	MGP_C3HHeJ_G0022134	protein coding gene	Chr15:103316796-103330926 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0022816	protein coding gene	Chr15:108182510-108195317 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0020339	protein coding gene	Chr15:95985023-95998700 (+)
CAST/EiJ	MGP_CASTEiJ_G0021660	protein coding gene	Chr15:104173464-104190329 (+)
CBA/J	MGP_CBAJ_G0022103	protein coding gene	Chr15:111963375-111983405 (+)
DBA/2J	MGP_DBA2J_G0022234	protein coding gene	Chr15:99497390-99510619 (+)
FVB/NJ	MGP_FVBNJ_G0022210	protein coding gene	Chr15:98557754-98568281 (+)
LP/J	MGP_LPJ_G0022303	protein coding gene	Chr15:104464392-104478504 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0022232	protein coding gene	Chr15:115555610-115569371 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0022828	protein coding gene	Chr15:103262778-103277460 (+)
PWK/PhJ	MGP_PWKPhJ_G0021400	protein coding gene	Chr15:99646580-99659843 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0021232	protein coding gene	Chr15:103107424-103120560 (+)
WSB/EiJ	MGP_WSBEiJ_G0021710	protein coding gene	Chr15:103892719-103911323 (+)

Human Ortholog

SOAT2, sterol O-acyltransferase 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SOAT2, sterol O-acyltransferase 2
Synonyms

ACACT2, ACAT2, ARGP2
Links

HGNC:11178

NCBI Gene ID: 8435

neXtProt AC: NX_O75908

UniProt: O75908
Chr Location

12q13.13; chr12:53103486-53124535 (+) GRCh38

MGI Vertebrate Homology

Soat2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: SOAT2
Protein SuperFamily

Oat_ACAT_DAG_ARE
Gene Tree

Soat2

Diseases

2 with human SOAT2 associations

				Human Disease	Mouse Models
				coronary artery disease IDs coronary artery disease DOID:3393 DOID:10506 DOID:3363 DOID:3394 DOID:9420 EFO:0001645 ICD10CM:I20-I25 ICD10CM:I25 ICD10CM:I25.10 ICD9CM:410-414.99 ICD9CM:414.0 ICD9CM:414.9 MESH:D003324 MESH:D003327 MESH:D017202 NCI:C35505 NCI:C50625 OMIM:300464 OMIM:607339 OMIM:608316 OMIM:608318 OMIM:608320 OMIM:610947 OMIM:611139 OMIM:612030 OMIM:614293 UMLS_CUI:C0010054 UMLS_CUI:C0010068 UMLS_CUI:C0151744 UMLS_CUI:C0264694
				hepatocellular carcinoma IDs hepatocellular carcinoma DOID:684 DOID:5005 EFO:0000182 ICD10CM:C22.0 MESH:D006528 NCI:C3099 OMIM:114550 ORDO:88673 UMLS_CUI:C2239176

Click on a disease name to see all genes associated with that disease.

References

1 with disease annotations

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Phenotype Summary

16 phenotypes from 2 alleles in 4 genetic backgrounds
5 phenotypes from multigenic genotypes
53 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

30
Chemically induced (other)

1
Endonuclease-mediated

4
Gene trapped

13
Radiation induced

2
Targeted

10
Genomic Mutations

3 involving Soat2
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

40 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous mutant animals exhibit elevated serum triglyceride levels and are resistant to fatty liver, hyperlipidemia, and gallstone development when fed a high fat, high cholesterol diet. When fed a Western diet homozygous mutant animals exhibit elevated HDL levels.

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All GO Annotations

30
GO References

10

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

806
Tissues

96
cDNA Data

10
Literature Summary

3

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase soat2

ZFIN soat2

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All Sequences

33
RefSeq

3
UniProt

2
CCDS

CCDS27872.1

Ensembl

ENSMUSG00000023045 (Evidence)
NCBI Gene

223920

			Length	Strain/Species	Flank
genomic	ENSMUSG00000023045	Ensembl Gene Model \| MGI Sequence Detail	12944	C57BL/6J	± kb
transcript	ENSMUST00000023806	Ensembl \| MGI Sequence Detail	2208	Not Applicable
polypeptide	ENSMUSP00000023806	Ensembl \| MGI Sequence Detail	525	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000015390 sterol O-acyltransferase 2

(term hierarchy)
EC

2.3.1.26
InterPro Domains

IPR004299 Membrane bound O-acyl transferase, MBOAT

IPR014371 Sterol O-acyltransferase, ACAT/DAG/ARE types

IPR030687 Sterol O-acyltransferase, metazoa

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All nucleic 12

cDNA 11

Primer pair 1

Microarray probesets 4

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MGD-MRK-34003, MGI:106311

Summaries

All 86

Developmental Gene Expression 3

Diseases 1

Gene Ontology 10

Phenotypes 53
Earliest

J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
Latest

J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;

TSS for Soat2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr133345	Chr15:102058796-102058811 (+)	-157 bp
Tssr133346	Chr15:102058817-102058828 (+)	-138 bp
Tssr133347	Chr15:102058840-102058853 (+)	-114 bp
Tssr133348	Chr15:102058937-102059012 (+)	14 bp
Tssr4737	Chr15:102059013-102059016 (+)	54 bp
Tssr133349	Chr15:102059025-102059036 (+)	70 bp
Tssr133350	Chr15:102059481-102059494 (+)	527 bp
Tssr133351	Chr15:102059513-102059533 (+)	562 bp
Tssr133352	Chr15:102059543-102059559 (+)	590 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/17/2024 MGI 6.24