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Cds2 Gene Detail
Summary
  • Symbol
    Cds2
  • Name
    CDP-diacylglycerol synthase 2
  • Synonyms
    5730450N06Rik, 5730460C18Rik, D2Wsu127e
  • Feature Type
    protein coding gene
  • IDs
    MGI:1332236
    NCBI Gene: 110911
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:132105068-132153970 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 64.15 cM, cytoband G1
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1566 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1332236
 protein coding gene Chr2:132105068-132153970 (+)
129S1/SvImJ MGP_129S1SvImJ_G0026541
 protein coding gene Chr2:135837103-135888133 (+)
A/J MGP_AJ_G0026505
 protein coding gene Chr2:130309028-130363127 (+)
AKR/J MGP_AKRJ_G0026479
 protein coding gene Chr2:134066362-134111059 (+)
BALB/cJ MGP_BALBcJ_G0026517
 protein coding gene Chr2:130714457-130761230 (+)
C3H/HeJ MGP_C3HHeJ_G0026260
 protein coding gene Chr2:134513678-134561730 (+)
C57BL/6NJ MGP_C57BL6NJ_G0026962
 protein coding gene Chr2:139965663-140021908 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0024339
 protein coding gene Chr2:125026473-125076657 (+)
CAST/EiJ MGP_CASTEiJ_G0025721
 protein coding gene Chr2:134830433-134886446 (+)
CBA/J MGP_CBAJ_G0026240
 protein coding gene Chr2:145226484-145274977 (+)
DBA/2J MGP_DBA2J_G0026374
 protein coding gene Chr2:129706512-129754237 (+)
FVB/NJ MGP_FVBNJ_G0026338
 protein coding gene Chr2:128332964-128381889 (+)
LP/J MGP_LPJ_G0026478
 protein coding gene Chr2:136035770-136090702 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0026358
 protein coding gene Chr2:148990834-149032466 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0027017
 protein coding gene Chr2:134035062-134076604 (+)
PWK/PhJ MGP_PWKPhJ_G0025457
 protein coding gene Chr2:129290665-129347447 (+)
SPRET/EiJ MGP_SPRETEiJ_G0025259
 protein coding gene Chr2:133184707-133238333 (+)
WSB/EiJ MGP_WSBEiJ_G0025795
 protein coding gene Chr2:134958150-135009987 (+)



Homology
more
  • Human Ortholog
    CDS2, CDP-diacylglycerol synthase 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CDS2, CDP-diacylglycerol synthase 2
  • Links
    NCBI Gene ID: 8760
    neXtProt AC: NX_O95674
    UniProt: O95674

  • Chr Location
    20p12.3; chr20:5126879-5197887 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 2 alleles in 2 genetic backgrounds
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene display a lethal phenotype. Heterozygotes show a distorted lymphocyte distribution and enhanced sensorimotor gating.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    18
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    876
  • Tissues
    143
  • cDNA Data
    158
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 110911 NCBI Gene Model | MGI Sequence Detail 48903 C57BL/6J ±  kb
    transcript NM_138651 RefSeq | MGI Sequence Detail 8412 ZRU/MplStud  
    polypeptide Q99L43 UniProt | EBI | MGI Sequence Detail 444 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      7 Sequences
    • Protein Ontology
      PR:000005291 phosphatidate cytidylyltransferase 2
      (term hierarchy)
    • EC
      2.7.7.41
    • InterPro Domains
      IPR000374 Phosphatidate cytidylyltransferase
      IPR016720 Phosphatidate cytidylyltransferase, eukaryota
    • GlyGen
      Q99L43 3 sites, 3 N-linked glycans (2 sites), 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 159
      cDNA 158
      Primer pair 1

      Microarray probesets 9
    Other
    Accession IDs
    less
    MGD-MRK-35819, MGI:107353, MGI:1917815, MGI:1924099, MGI:2139105
    References
    more
    • Summaries
      All 56
      Developmental Gene Expression 5
      Gene Ontology 9
      Phenotypes 18
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:358515 Collins DM, et al., CDS2 expression regulates de novo phosphatidic acid synthesis. Biochem J. 2024 Oct 16;481(20):1449-1473
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    12/17/2024
    MGI 6.24     		The Jackson Laboratory