Dok2 MGI Mouse Gene Detail - MGI:1332623

Symbol

Dok2
Name

docking protein 2
Synonyms

DokR, Frip, Frip

Feature Type

protein coding gene
IDs

MGI:1332623
NCBI Gene: 13449
Alliance

gene page
Transcription Start Sites

10 TSS

Sequence Map

Chr14:71003476-71015935 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 14, 36.71 cM, cytoband D2-D3
Mapping Data

2 experiments

SNPs within 2kb

290 from dbSNP Build 142
Strain Annotations

18
PCR

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1332623	protein coding gene	Chr14:71003336-71015935 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0021550	protein coding gene	Chr14:65430174-65442631 (+)
A/J	MGP_AJ_G0021509	protein coding gene	Chr14:64027175-64039630 (+)
AKR/J	MGP_AKRJ_G0021485	protein coding gene	Chr14:65951874-65964314 (+)
BALB/cJ	MGP_BALBcJ_G0021515	protein coding gene	Chr14:63792650-63805264 (+)
C3H/HeJ	MGP_C3HHeJ_G0021292	protein coding gene	Chr14:65667321-65679676 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0021954	protein coding gene	Chr14:68338402-68350742 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0019494	protein coding gene	Chr14:61864734-61877025 (+)
CAST/EiJ	MGP_CASTEiJ_G0020809	protein coding gene	Chr14:62261755-62274090 (+)
CBA/J	MGP_CBAJ_G0021259	protein coding gene	Chr14:70495648-70508059 (+)
DBA/2J	MGP_DBA2J_G0021382	protein coding gene	Chr14:63417025-63429735 (+)
FVB/NJ	MGP_FVBNJ_G0021361	protein coding gene	Chr14:62845763-62858142 (+)
LP/J	MGP_LPJ_G0021453	protein coding gene	Chr14:66668835-66681327 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0021390	protein coding gene	Chr14:69379176-69391652 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0021978	protein coding gene	Chr14:65212810-65226359 (+)
PWK/PhJ	MGP_PWKPhJ_G0020553	protein coding gene	Chr14:60185130-60197405 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0020386	protein coding gene	Chr14:61138763-61151315 (+)
WSB/EiJ	MGP_WSBEiJ_G0020862	protein coding gene	Chr14:65525202-65538027 (+)

Human Ortholog

DOK2, docking protein 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

DOK2, docking protein 2
Synonyms

p56DOK, p56dok-2
Links

HGNC:2991

NCBI Gene ID: 9046

neXtProt AC: NX_O60496

UniProt: O60496
Chr Location

8p21.3; chr8:21908873-21913690 (-) GRCh38

MGI Vertebrate Homology

Dok2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: DOK2
Gene Tree

Dok2

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Mutations/Alleles

2 with disease annotations

References

2 with disease annotations

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Phenotype Summary

3 phenotypes from 1 allele in 1 genetic background
26 phenotypes from multigenic genotypes
28 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

16
Chemically induced (other)

1
Endonuclease-mediated

3
Gene trapped

8
Targeted

4
Genomic Mutations

1 involving Dok2
Find Mice (IMSR)

16 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous null mice display abnormal granulocyte physiology.

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All GO Annotations

9
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

724
Tissues

16
cDNA Data

10
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase dok2

ZFIN dok2

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All Sequences

60
RefSeq

18
UniProt

3
CCDS

CCDS27262.1

Ensembl

ENSMUSG00000022102 (Evidence)
NCBI Gene

13449

			Length	Strain/Species	Flank
genomic	ENSMUSG00000022102	Ensembl Gene Model \| MGI Sequence Detail	12460	C57BL/6J	± kb
transcript	ENSMUST00000022698	Ensembl \| MGI Sequence Detail	1795	Not Applicable
polypeptide	ENSMUSP00000022698	Ensembl \| MGI Sequence Detail	412	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000006629 docking protein 2

(term hierarchy)
InterPro Domains

IPR050996 Docking Protein Family (DOK)

IPR037751 Dok1/2/3, PTB domain

IPR002404 IRS-type PTB domain

IPR011993 PH-like domain superfamily

IPR001849 Pleckstrin homology domain

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All nucleic 13

Genomic 2

cDNA 10

Primer pair 1

Microarray probesets 4

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MGI:1261852

Summaries

All 57

Developmental Gene Expression 2

Diseases 2

Gene Ontology 4

Phenotypes 28
Earliest

J:43960 Nelms K, et al., FRIP, a hematopoietic cell-specific rasGAP-interacting protein phosphorylated in response to cytokine stimulation. Immunity. 1998 Jul;9(1):13-24
Latest

J:270610 Chen M, et al., Compound haploinsufficiency of Dok2 and Dusp4 promotes lung tumorigenesis. J Clin Invest. 2019 Jan 2;129(1):215-222

TSS for Dok2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr126478	Chr14:71010687-71010698 (+)	7,217 bp
Tssr126479	Chr14:71010702-71010741 (+)	7,246 bp
Tssr126480	Chr14:71011778-71011793 (+)	8,310 bp
Tssr126481	Chr14:71011796-71011810 (+)	8,327 bp
Tssr126482	Chr14:71011815-71011841 (+)	8,352 bp
Tssr126483	Chr14:71011852-71011863 (+)	8,382 bp
Tssr126484	Chr14:71012041-71012050 (+)	8,570 bp
Tssr126485	Chr14:71012413-71012424 (+)	8,943 bp
Tssr126486	Chr14:71013611-71013618 (+)	10,139 bp
Tssr126487	Chr14:71013662-71013671 (+)	10,191 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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