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Arhgap5 Gene Detail
Summary
  • Symbol
    Arhgap5
  • Name
    Rho GTPase activating protein 5
  • Synonyms
    p190-B, p190B
  • Feature Type
    protein coding gene
  • IDs
    MGI:1332637
    NCBI Gene: 11855
  • Alliance
    gene page
  • Transcription Start Sites
    12 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:52550755-52618758 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 12, 22.16 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1183 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1332637
 protein coding gene Chr12:52550555-52618761 (+)
129S1/SvImJ MGP_129S1SvImJ_G0019732
 protein coding gene Chr12:51330752-51399137 (+)
A/J MGP_AJ_G0019694
 protein coding gene Chr12:49519650-49582909 (+)
AKR/J MGP_AKRJ_G0019665
 protein coding gene Chr12:51009736-51073861 (+)
BALB/cJ MGP_BALBcJ_G0019672
 protein coding gene Chr12:49793253-49861743 (+)
C3H/HeJ MGP_C3HHeJ_G0019475
 protein coding gene Chr12:51118616-51182142 (+)
C57BL/6NJ MGP_C57BL6NJ_G0020120
 protein coding gene Chr12:52931377-52995900 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017743
 protein coding gene Chr12:47888613-47954995 (+)
CAST/EiJ MGP_CASTEiJ_G0019028
 protein coding gene Chr12:46156566-46228669 (+)
CBA/J MGP_CBAJ_G0019447
 protein coding gene Chr12:54719281-54802367 (+)
DBA/2J MGP_DBA2J_G0019561
 protein coding gene Chr12:49389289-49452757 (+)
FVB/NJ MGP_FVBNJ_G0019550
 protein coding gene Chr12:48823135-48890687 (+)
LP/J MGP_LPJ_G0019633
 protein coding gene Chr12:51373595-51442210 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0019586
 protein coding gene Chr12:56371252-56447992 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0020158
 protein coding gene Chr12:50519123-50587015 (+)
PWK/PhJ MGP_PWKPhJ_G0018795
 protein coding gene Chr12:43968972-44036993 (+)
SPRET/EiJ MGP_SPRETEiJ_G0018589
 protein coding gene Chr12:45098091-45160211 (+)
WSB/EiJ MGP_WSBEiJ_G0019079
 protein coding gene Chr12:50997704-51064286 (+)



Homology
more
  • Human Ortholog
    ARHGAP5, Rho GTPase activating protein 5
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ARHGAP5, Rho GTPase activating protein 5
  • Synonyms
    GFI2, p190-B, p190BRhoGAP, RhoGAP5
  • Links
    NCBI Gene ID: 394
    neXtProt AC: NX_Q13017
    UniProt: Q13017

  • Chr Location
    14q12; chr14:32076114-32159728 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    12 phenotypes from 1 allele in 2 genetic backgrounds
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes die at birth, are 30% smaller, do not inflate their lungs, and show a small thymus, abnormal adipocyte differentiation and brain defects in the corpus callosum, anterior commissure and lateral ventricles. Mutant MEFs show impaired adipogenesis but undergo myogenesis in response to IGF-1.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    19
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    902
  • Tissues
    125
  • cDNA Data
    13
  • Literature Summary
    10
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000035133 Ensembl Gene Model | MGI Sequence Detail 68004 C57BL/6J ±  kb
    transcript ENSMUST00000219443 Ensembl | MGI Sequence Detail 9323 Not Applicable  
    polypeptide ENSMUSP00000151809 Ensembl | MGI Sequence Detail 1503 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      5 Sequences
    • Protein Ontology
      PR:000004238 Rho GTPase-activating protein 5
      (term hierarchy)
    • InterPro Domains
      IPR002713 FF domain
      IPR036517 FF domain superfamily
      IPR027417 P-loop containing nucleoside triphosphate hydrolase
      IPR051978 Rho GTPase-activating domain-containing protein
      IPR000198 Rho GTPase-activating protein domain
      IPR032835 Rho GTPase-activating protein, FF domain
      IPR045786 Rho GTPase-activating protein, pG1 and pG2 domain
      IPR039007 Rho GTPase-activating protein, pG1 domain
      IPR039006 Rho GTPase-activating protein, pG2 domain
      IPR008936 Rho GTPase activation protein
    • GlyGen
      P97393 1 site, 1 N-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 19
      Genomic 3
      cDNA 13
      Primer pair 1
      Other 2

      Microarray probesets 8
    References
    more
    • Summaries
      All 47
      Developmental Gene Expression 10
      Gene Ontology 8
      Phenotypes 14
    • Earliest
      J:51802 Burbelo PD, et al., Cloning, genomic organization and chromosomal assignment of the mouse p190-B gene. Biochim Biophys Acta. 1998 Nov 26;1443(1-2):203-10
    • Latest
      J:313853 Watanabe K, et al., ILDR2 stabilization is regulated by its interaction with GRP78. Sci Rep. 2021 Apr 16;11(1):8414
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory