Bnip3l MGI Mouse Gene Detail - MGI:1332659 - BCL2/adenovirus E1B interacting protein 3-like

Symbol

Bnip3l
Name

BCL2/adenovirus E1B interacting protein 3-like
Synonyms

D14Ertd719e, Nip3L, Nix

Feature Type

protein coding gene
IDs

MGI:1332659
NCBI Gene: 12177
Alliance

gene page
Transcription Start Sites

9 TSS

Sequence Map

Chr14:67222688-67246326 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 14, 34.60 cM
Mapping Data

4 experiments

SNPs within 2kb

480 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1332659	protein coding gene	Chr14:67222688-67246580 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0021501	protein coding gene	Chr14:61693741-61719592 (-)
A/J	MGP_AJ_G0021460	protein coding gene	Chr14:60198638-60225618 (-)
AKR/J	MGP_AKRJ_G0021436	protein coding gene	Chr14:62273317-62297364 (-)
BALB/cJ	MGP_BALBcJ_G0021466	protein coding gene	Chr14:60200487-60234572 (-)
C3H/HeJ	MGP_C3HHeJ_G0021243	protein coding gene	Chr14:62003992-62027548 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0021905	protein coding gene	Chr14:64506197-64535605 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0019445	protein coding gene	Chr14:58123547-58147199 (-)
CAST/EiJ	MGP_CASTEiJ_G0020760	protein coding gene	Chr14:58473277-58499991 (-)
CBA/J	MGP_CBAJ_G0021210	protein coding gene	Chr14:66489866-66519627 (-)
DBA/2J	MGP_DBA2J_G0021333	protein coding gene	Chr14:59854493-59878346 (-)
FVB/NJ	MGP_FVBNJ_G0021312	protein coding gene	Chr14:59257636-59283648 (-)
LP/J	MGP_LPJ_G0021408	protein coding gene	Chr14:62745926-62772174 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0021341	protein coding gene	Chr14:65506087-65530907 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0021928	protein coding gene	Chr14:61501384-61527488 (-)
PWK/PhJ	MGP_PWKPhJ_G0020504	protein coding gene	Chr14:56594420-56619319 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0020337	protein coding gene	Chr14:57459898-57489228 (-)
WSB/EiJ	MGP_WSBEiJ_G0020813	protein coding gene	Chr14:61820592-61850652 (-)

Human Ortholog

BNIP3L, BCL2 interacting protein 3 like

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

BNIP3L, BCL2 interacting protein 3 like
Synonyms

BNIP3a, NIP3L, NIX
Links

HGNC:1085

NCBI Gene ID: 665

neXtProt AC: NX_O60238

UniProt: O60238
Chr Location

8p21.2; chr8:26383054-26505636 (+) GRCh38

MGI Vertebrate Homology

Bnip3l stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: BNIP3L
Gene Tree

Bnip3l

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Phenotype Summary

32 phenotypes from 4 alleles in 5 genetic backgrounds
9 phenotypes from multigenic genotypes
2 images
29 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

22
Chemically induced (other)

1
Endonuclease-mediated

3
Gene trapped

13
Targeted

5
Genomic Mutations

1 involving Bnip3l
Incidental Mutations

CvDC
Find Mice (IMSR)

41 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele exhibit abnormal morphology, decreased numbers and increased fragility of reticulocyte and erythcrocyte.

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All GO Annotations

51
GO References

14

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

864
Tissues

131
cDNA Data

20
Literature Summary

14

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA BNIP3L

Xenbase bnip3l

ZFIN bnip3lb

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All Sequences

62
RefSeq

12
UniProt

3
CCDS

CCDS27227.1

Ensembl

ENSMUSG00000022051 (Evidence)
NCBI Gene

12177

			Length	Strain/Species	Flank
genomic	ENSMUSG00000022051	Ensembl Gene Model \| MGI Sequence Detail	23639	C57BL/6J	± kb
transcript	ENSMUST00000022634	Ensembl \| MGI Sequence Detail	3238	Not Applicable
polypeptide	ENSMUSP00000022634	Ensembl \| MGI Sequence Detail	218	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000004782 BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like

(term hierarchy)
InterPro Domains

IPR010548 BNIP3

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All nucleic 24

cDNA 21

Primer pair 3

Microarray probesets 6

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MGI:1289182, MGI:2145873

Summaries

All 88

Developmental Gene Expression 14

Gene Ontology 14

Phenotypes 29
Earliest

J:51799 Chen G, et al., Nix and Nip3 form a subfamily of pro-apoptotic mitochondrial proteins. J Biol Chem. 1999 Jan 1;274(1):7-10
Latest

J:346871 Liu K, et al., BNIP3 (BCL2 interacting protein 3) regulates pluripotency by modulating mitochondrial homeostasis via mitophagy. Cell Death Dis. 2022 Apr 11;13(4):334

TSS for Bnip3l:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr129375	Chr14:67246283-67246316 (-)	26 bp
Tssr129374	Chr14:67245974-67245991 (-)	343 bp
Tssr129373	Chr14:67245534-67245539 (-)	789 bp
Tssr129372	Chr14:67243883-67243887 (-)	2,441 bp
Tssr129371	Chr14:67237937-67237951 (-)	8,382 bp
Tssr129370	Chr14:67237912-67237934 (-)	8,403 bp
Tssr129369	Chr14:67237890-67237904 (-)	8,429 bp
Tssr129368	Chr14:67237350-67237375 (-)	8,963 bp
Tssr129367	Chr14:67223476-67223489 (-)	22,843 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24