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Mapkapk5 Gene Detail
Summary
  • Symbol
    Mapkapk5
  • Name
    MAP kinase-activated protein kinase 5
  • Synonyms
    MK5, PRAK
  • Feature Type
    protein coding gene
  • IDs
    MGI:1333110
    NCBI Gene: 17165
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:121663114-121683955 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 61.84 cM, cytoband F
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    470 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1333110
 protein coding gene Chr5:121663101-121683968 (-)
129S1/SvImJ MGP_129S1SvImJ_G0030032
 protein coding gene Chr5:125017856-125041949 (-)
A/J MGP_AJ_G0029997
 protein coding gene Chr5:119868944-119890485 (-)
AKR/J MGP_AKRJ_G0029933
 protein coding gene Chr5:123745265-123765773 (-)
BALB/cJ MGP_BALBcJ_G0030008
 protein coding gene Chr5:121255445-121275801 (-)
C3H/HeJ MGP_C3HHeJ_G0029725
 protein coding gene Chr5:124313155-124341792 (-)
C57BL/6NJ MGP_C57BL6NJ_G0030461
 protein coding gene Chr5:129776264-129801674 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027687
 protein coding gene Chr5:114543360-114563207 (-)
CAST/EiJ MGP_CASTEiJ_G0029134
 protein coding gene Chr5:123422778-123447528 (-)
CBA/J MGP_CBAJ_G0029695
 protein coding gene Chr5:134880881-134913456 (-)
DBA/2J MGP_DBA2J_G0029845
 protein coding gene Chr5:119938329-119959319 (-)
FVB/NJ MGP_FVBNJ_G0029801
 protein coding gene Chr5:118893747-118916581 (-)
LP/J MGP_LPJ_G0029934
 protein coding gene Chr5:125531393-125558570 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0029832
 protein coding gene Chr5:138732613-138756534 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0030502
 protein coding gene Chr5:123267009-123293194 (-)
PWK/PhJ MGP_PWKPhJ_G0028848
 protein coding gene Chr5:118715144-118735979 (-)
SPRET/EiJ MGP_SPRETEiJ_G0028685
 protein coding gene Chr5:121025230-121045273 (-)
WSB/EiJ MGP_WSBEiJ_G0029209
 protein coding gene Chr5:123921298-123942273 (-)



Homology
more
  • Human Ortholog
    MAPKAPK5, MAPK activated protein kinase 5
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MAPKAPK5, MAPK activated protein kinase 5
  • Synonyms
    MAPKAP-K5, MK-5, MK5, NCFD, PRAK
  • Links
    NCBI Gene ID: 8550
    neXtProt AC: NX_Q8IW41
    UniProt: Q8IW41

  • Chr Location
    12q24.12-q24.13; chr12:111842013-111902222 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 3 alleles in 3 genetic backgrounds
    1 phenotype from multigenic genotypes
    26 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutant mice are viable, fertile, and show no overt abnormalities.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    64
  • GO References
    15
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    724
  • Tissues
    16
  • cDNA Data
    50
  • Literature Summary
    2
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 17165 NCBI Gene Model | MGI Sequence Detail 20842 C57BL/6J ±  kb
transcript NM_010765 RefSeq | MGI Sequence Detail 2229 Not Specified  
polypeptide O54992 UniProt | EBI | MGI Sequence Detail 473 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    5 Sequences
  • Protein Ontology
    PR:000010167 MAP kinase-activated protein kinase 5
    (term hierarchy)
  • EC
    2.7.11.1
  • InterPro Domains
    IPR050205 Calcium-dependent Serine/Threonine Protein Kinases
    IPR027442 MAP kinase activated protein kinase, C-terminal
    IPR000719 Protein kinase domain
    IPR011009 Protein kinase-like domain superfamily
    IPR008271 Serine/threonine-protein kinase, active site
  • GlyGen
    O54992 2 sites, 1 O-linked glycan (2 sites)
Molecular
Reagents
less
  • All nucleic 52
    cDNA 51
    Primer pair 1

    Microarray probesets 3
References
more
  • Summaries
    All 57
    Developmental Gene Expression 2
    Gene Ontology 15
    Phenotypes 26
  • Earliest
    J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory