About   Help   FAQ
Ran Gene Detail
Summary
  • Symbol
    Ran
  • Name
    RAN, member RAS oncogene family
  • Feature Type
    protein coding gene
  • IDs
    MGI:1333112
    NCBI Gene: 19384
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:129097264-129101388 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 67.99 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    190 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1333112
 protein coding gene Chr5:129097133-129101388 (+)
129S1/SvImJ MGP_129S1SvImJ_G0030123
 protein coding gene Chr5:133077215-133082297 (+)
A/J MGP_AJ_G0030090
 protein coding gene Chr5:127483386-127489322 (+)
AKR/J MGP_AKRJ_G0030024
 protein coding gene Chr5:131627589-131628175 (+)
BALB/cJ MGP_BALBcJ_G0030100
 protein coding gene Chr5:128830535-128831121 (+)
C3H/HeJ MGP_C3HHeJ_G0029817
 protein coding gene Chr5:132196229-132201223 (+)
C57BL/6NJ MGP_C57BL6NJ_G0030553
 protein coding gene Chr5:138180967-138189196 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0027778
 protein coding gene Chr5:121887494-121891763 (+)
CAST/EiJ MGP_CASTEiJ_G0029226
 protein coding gene Chr5:131464037-131470647 (+)
CBA/J MGP_CBAJ_G0029787
 protein coding gene Chr5:143548202-143553280 (+)
DBA/2J MGP_DBA2J_G0029937
 protein coding gene Chr5:127469021-127469607 (+)
FVB/NJ MGP_FVBNJ_G0029893
 protein coding gene Chr5:126533526-126537781 (+)
LP/J MGP_LPJ_G0030026
 protein coding gene Chr5:133586611-133591764 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0029924
 protein coding gene Chr5:146939856-146944110 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0030594
 protein coding gene Chr5:131305842-131309925 (+)
PWK/PhJ MGP_PWKPhJ_G0028940
 protein coding gene Chr5:126373745-126378680 (+)
SPRET/EiJ MGP_SPRETEiJ_G0028777
 protein coding gene Chr5:128874665-128878334 (+)
WSB/EiJ MGP_WSBEiJ_G0029300
 protein coding gene Chr5:131959029-131962083 (+)



Homology
more
  • Human Ortholog
    RAN, RAN, member RAS oncogene family
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RAN, RAN, member RAS oncogene family
  • Synonyms
    ARA24, Gsp1, TC4
  • Links
    NCBI Gene ID: 5901
    neXtProt AC: NX_P62826
    UniProt: P62826

  • Chr Location
    12q24.33; chr12:130872037-130877678 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human RAN associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    14 phenotype references
  • All Mutations and Alleles
    32
  • Chemically induced (other)
    1
  • Endonuclease-mediated
    2
  • Gene trapped
    26
  • Radiation induced
    1
  • Targeted
    2
  • Genomic Mutations
    2 involving Ran
  • Find Mice (IMSR)
    23 strains or lines available
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    66
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    823
  • Tissues
    95
  • cDNA Data
    23
  • Literature Summary
    12
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 19384 NCBI Gene Model | MGI Sequence Detail 4125 C57BL/6J ±  kb
transcript NM_001421198 RefSeq | MGI Sequence Detail 2266 C57BL/6  
polypeptide P62827 UniProt | EBI | MGI Sequence Detail 216 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 25
    cDNA 24
    Other 1

    Microarray probesets 5
References
more
  • Summaries
    All 71
    Developmental Gene Expression 12
    Gene Ontology 11
    Phenotypes 14
  • Earliest
    J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
  • Latest
    J:351854 Nelson AT, et al., Glucose hypometabolism prompts RAN translation and exacerbates C9orf72-related ALS/FTD phenotypes. EMBO Rep. 2024 May;25(5):2479-2510
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory