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Pigq Gene Detail
Summary
  • Symbol
    Pigq
  • Name
    phosphatidylinositol glycan anchor biosynthesis, class Q
  • Synonyms
    Gpi1, Gpi1h, Gpi1p, Gpih
  • Feature Type
    protein coding gene
  • IDs
    MGI:1333114
    NCBI Gene: 14755
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:26145398-26161855 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 13.01 cM, cytoband B
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    408 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1333114
 protein coding gene Chr17:26145395-26163910 (-)
129S1/SvImJ MGP_129S1SvImJ_G0023382
 protein coding gene Chr17:25038004-25057281 (-)
A/J MGP_AJ_G0023341
 protein coding gene Chr17:24299074-24318769 (-)
AKR/J MGP_AKRJ_G0023307
 protein coding gene Chr17:24412629-24430405 (-)
BALB/cJ MGP_BALBcJ_G0023346
 protein coding gene Chr17:24530344-24548236 (-)
C3H/HeJ MGP_C3HHeJ_G0023106
 protein coding gene Chr17:24792481-24812697 (-)
C57BL/6NJ MGP_C57BL6NJ_G0023788
 protein coding gene Chr17:26092137-26111284 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021264
 protein coding gene Chr17:21764570-21782109 (-)
CAST/EiJ MGP_CASTEiJ_G0022608
 protein coding gene Chr17:24687921-24705388 (-)
CBA/J MGP_CBAJ_G0023081
 protein coding gene Chr17:27012505-27036353 (-)
DBA/2J MGP_DBA2J_G0023211
 protein coding gene Chr17:23902686-23920464 (-)
FVB/NJ MGP_FVBNJ_G0023181
 protein coding gene Chr17:23654025-23672066 (-)
LP/J MGP_LPJ_G0023288
 protein coding gene Chr17:25328611-25348288 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0023200
 protein coding gene Chr17:26607327-26625301 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0023828
 protein coding gene Chr17:24729015-24750596 (-)
PWK/PhJ MGP_PWKPhJ_G0022357
 protein coding gene Chr17:22677848-22695999 (-)
SPRET/EiJ MGP_SPRETEiJ_G0022175
 protein coding gene Chr17:22809802-22828227 (-)
WSB/EiJ MGP_WSBEiJ_G0022671
 protein coding gene Chr17:24783498-24803430 (-)



Homology
more
  • Human Ortholog
    PIGQ, phosphatidylinositol glycan anchor biosynthesis class Q
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PIGQ, phosphatidylinositol glycan anchor biosynthesis class Q
  • Synonyms
    c407A10.1, DEE77, EIEE77, GPI1, GPIBD19, MCAHS4
  • Links
    NCBI Gene ID: 9091
    neXtProt AC: NX_Q9BRB3
    UniProt: Q9BRB3

  • Chr Location
    16p13.3; chr16:566995-584109 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human PIGQ associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    35 phenotypes from 1 allele in 1 genetic background
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    15
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    877
  • Tissues
    138
  • cDNA Data
    152
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 14755 NCBI Gene Model | MGI Sequence Detail 16458 C57BL/6J ±  kb
    transcript NM_001291025 RefSeq | MGI Sequence Detail 3234 C57BL/6  
    polypeptide Q9QYT7 UniProt | EBI | MGI Sequence Detail 581 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      16 Sequences
    • Protein Ontology
      PR:000012704 phosphatidylinositol N-acetylglucosaminyltransferase subunit Q
      (term hierarchy)
    • InterPro Domains
      IPR007720 Phosphatidylinositol N-acetylglucosaminyltransferase subunit Q/GPI1
    Molecular
    Reagents
    less
    • All nucleic 154
      cDNA 154

      Microarray probesets 11
    Other
    Accession IDs
    less
    MGI:1345628
    References
    more
    • Summaries
      All 42
      Developmental Gene Expression 3
      Gene Ontology 7
      Phenotypes 12
    • Earliest
      J:50634 Tiede A, et al., Human and mouse Gpi1p homologues restore glycosylphosphatidylinositol membrane anchor biosynthesis in yeast mutants. Biochem J. 1998 Sep 15;334(Pt 3):609-16
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    12/10/2024
    MGI 6.24     		The Jackson Laboratory