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Gp1ba Gene Detail
Summary
  • Symbol
    Gp1ba
  • Name
    glycoprotein 1b, alpha polypeptide
  • Synonyms
    GPIba, GP Ib-alpha, GPIb-alpha
  • Feature Type
    protein coding gene
  • IDs
    MGI:1333744
    NCBI Gene: 14723
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:70529948-70532862 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 43.20 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    35 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1333744
 protein coding gene Chr11:70529928-70534812 (+)
129S1/SvImJ MGP_129S1SvImJ_G0018606
 protein coding gene Chr11:71182312-71185226 (+)
A/J MGP_AJ_G0018574
 protein coding gene Chr11:68493718-68496632 (+)
AKR/J MGP_AKRJ_G0018543
 protein coding gene Chr11:70550990-70553904 (+)
BALB/cJ MGP_BALBcJ_G0018546
 protein coding gene Chr11:68802859-68805773 (+)
C3H/HeJ MGP_C3HHeJ_G0018359
 protein coding gene Chr11:70569637-70572551 (+)
C57BL/6NJ MGP_C57BL6NJ_G0018997
 protein coding gene Chr11:73339438-73342352 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0016642
 protein coding gene Chr11:65401739-65404598 (+)
CAST/EiJ MGP_CASTEiJ_G0017914
 protein coding gene Chr11:70827004-70829918 (+)
CBA/J MGP_CBAJ_G0018331
 protein coding gene Chr11:76643104-76646018 (+)
DBA/2J MGP_DBA2J_G0018441
 protein coding gene Chr11:68067000-68069914 (+)
FVB/NJ MGP_FVBNJ_G0018431
 protein coding gene Chr11:67707735-67710601 (+)
LP/J MGP_LPJ_G0018511
 protein coding gene Chr11:71762965-71765879 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0018454
 protein coding gene Chr11:77198216-77201130 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0019039
 protein coding gene Chr11:70806869-70809783 (+)
PWK/PhJ MGP_PWKPhJ_G0017688
 protein coding gene Chr11:68714083-68716997 (+)
SPRET/EiJ MGP_SPRETEiJ_G0017478
 protein coding gene Chr11:70622376-70625328 (+)
WSB/EiJ MGP_WSBEiJ_G0017968
 protein coding gene Chr11:70467612-70470526 (+)



Homology
more
  • Human Ortholog
    GP1BA, glycoprotein Ib platelet subunit alpha
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GP1BA, glycoprotein Ib platelet subunit alpha
  • Synonyms
    BDPLT1, BDPLT3, BSS, CD42B, CD42b-alpha, DBPLT3, GP1B, GPIbA, GPIbalpha, VWDP
  • Links
    NCBI Gene ID: 2811
    neXtProt AC: NX_P07359
    UniProt: P07359

  • Chr Location
    17p13.2; chr17:4932277-4935023 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Gp1ba mouse models; 5 with human GP1BA associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 2 alleles in 2 genetic backgrounds
    2 images
    57 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a targeted null mutation exhibit prolonged bleeding times and reduced numbers of enlarged platelets. Heterozygotes have intermediate numbers of platelets.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    31
  • GO References
    14
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    714
  • Tissues
    4
  • cDNA Data
    2
  • Literature Summary
    2
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000050675 Ensembl Gene Model | MGI Sequence Detail 2915 C57BL/6J ±  kb
transcript ENSMUST00000108551 Ensembl | MGI Sequence Detail 2480 Not Applicable  
polypeptide ENSMUSP00000104191 Ensembl | MGI Sequence Detail 734 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 8
    Genomic 4
    cDNA 2
    Primer pair 1
    Other 1

    Microarray probesets 3
References
more
  • Summaries
    All 102
    Developmental Gene Expression 2
    Diseases 1
    Gene Ontology 14
    Phenotypes 57
  • Earliest
    J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
  • Latest
    J:354028 Ballard-Kordeliski A, et al., 4D intravital imaging studies identify platelets as the predominant cellular procoagulant surface in a mouse hemostasis model. Blood. 2024 Sep 5;144(10):1116-1126
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory