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Rps19 Gene Detail
Summary
  • Symbol
    Rps19
  • Name
    ribosomal protein S19
  • Synonyms
    Dsk3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1333780
    NCBI Gene: 20085
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:24584013-24589236 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 13.41 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    268 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1333780
 protein coding gene Chr7:24583796-24589236 (+)
129S1/SvImJ MGP_129S1SvImJ_G0031846
 protein coding gene Chr7:23294671-23300104 (+)
A/J MGP_AJ_G0031825
 protein coding gene Chr7:22721257-22726697 (+)
AKR/J MGP_AKRJ_G0031754
 protein coding gene Chr7:23252370-23260607 (+)
BALB/cJ MGP_BALBcJ_G0031833
 protein coding gene Chr7:22927048-22932481 (+)
C3H/HeJ MGP_C3HHeJ_G0031551
 protein coding gene Chr7:23667673-23673126 (+)
C57BL/6NJ MGP_C57BL6NJ_G0032294
 protein coding gene Chr7:24065653-24073828 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0029349
 protein coding gene Chr7:24155019-24160328 (+)
CAST/EiJ MGP_CASTEiJ_G0030891
 protein coding gene Chr7:17144844-17150972 (+)
CBA/J MGP_CBAJ_G0031516
 protein coding gene Chr7:24948390-24955764 (+)
DBA/2J MGP_DBA2J_G0031670
 protein coding gene Chr7:22626364-22631798 (+)
FVB/NJ MGP_FVBNJ_G0031623
 protein coding gene Chr7:22603359-22608855 (+)
LP/J MGP_LPJ_G0031749
 protein coding gene Chr7:23604751-23610262 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0031660
 protein coding gene Chr7:24689713-24695838 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0032326
 protein coding gene Chr7:22952432-22958197 (+)
PWK/PhJ MGP_PWKPhJ_G0030615
 protein coding gene Chr7:17555010-17560599 (+)
SPRET/EiJ MGP_SPRETEiJ_G0030446
 protein coding gene Chr7:14263760-14269216 (+)
WSB/EiJ MGP_WSBEiJ_G0030995
 protein coding gene Chr7:23112320-23117750 (+)



Homology
more
  • Human Ortholog
    RPS19, ribosomal protein S19
  • Vertebrate Orthologs
    5
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RPS19, ribosomal protein S19
  • Synonyms
    DBA, DBA1, eS19, LOH19CR1, S19
  • Links
    NCBI Gene ID: 6223
    neXtProt AC: NX_P39019
    UniProt: P39019

  • Chr Location
    19q13.2; chr19:41860255-41872925 (+)  GRCh38
Human Diseases
more
  • Diseases
    2 with human RPS19 associations

Human Disease Mouse Models
      
IDs
 View 4 models
IDs
Click on a disease name to see all genes associated with that disease.

  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    18 phenotypes from 2 alleles in 5 genetic backgrounds
    4 phenotypes from multigenic genotypes
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null embryos die prior to the formation of a blastocyst. Mice heterozygous for some point mutations show pigment defects affecting the feet and tail.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    50
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    714
  • Tissues
    3
  • cDNA Data
    9
  • Literature Summary
    9
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 20085 NCBI Gene Model | MGI Sequence Detail 5224 C57BL/6J ±  kb
    transcript NM_001360118 RefSeq | MGI Sequence Detail 749 C57BL/6  
    polypeptide Q9CZX8 UniProt | EBI | MGI Sequence Detail 145 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 12
      cDNA 10
      Primer pair 2

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:2450683
    References
    more
    • Summaries
      All 61
      Developmental Gene Expression 9
      Diseases 1
      Gene Ontology 9
      Phenotypes 18
    • Earliest
      J:52537 Draptchinskaia N, et al., The gene encoding ribosomal protein S19 is mutated in Diamond-Blackfan anaemia. Nat Genet. 1999 Feb;21(2):169-75
    • Latest
      J:333015 Li H, et al., A male germ-cell-specific ribosome controls male fertility. Nature. 2022 Dec;612(7941):725-731
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory