Car6 MGI Mouse Gene Detail - MGI:1333786

Symbol

Car6
Name

carbonic anhydrase 6
Synonyms

DOC1

Feature Type

protein coding gene
IDs

MGI:1333786
NCBI Gene: 12353
Alliance

gene page
Transcription Start Sites

19 TSS

Sequence Map

Chr4:150271472-150285592 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 4, 81.12 cM
Mapping Data

1 experiment

SNPs within 2kb

177 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1333786	protein coding gene	Chr4:150271472-150285789 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0029152	protein coding gene	Chr4:154122828-154138506 (-)
A/J	MGP_AJ_G0029117	protein coding gene	Chr4:147669577-147684156 (-)
AKR/J	MGP_AKRJ_G0029065	protein coding gene	Chr4:151724962-151740380 (-)
BALB/cJ	MGP_BALBcJ_G0029133	protein coding gene	Chr4:148167066-148181231 (-)
C3H/HeJ	MGP_C3HHeJ_G0028854	protein coding gene	Chr4:152260738-152278369 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0029582	protein coding gene	Chr4:159677894-159693568 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0026828	protein coding gene	Chr4:140074947-140091251 (-)
CAST/EiJ	MGP_CASTEiJ_G0028267	protein coding gene	Chr4:149521728-149536489 (-)
CBA/J	MGP_CBAJ_G0028816	protein coding gene	Chr4:164382317-164401576 (-)
DBA/2J	MGP_DBA2J_G0028965	protein coding gene	Chr4:147760603-147774820 (-)
FVB/NJ	MGP_FVBNJ_G0028929	protein coding gene	Chr4:146890305-146904447 (-)
LP/J	MGP_LPJ_G0029055	protein coding gene	Chr4:154055765-154072795 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0028956	protein coding gene	Chr4:167536094-167551268 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0029614	protein coding gene	Chr4:152225996-152243115 (-)
PWK/PhJ	MGP_PWKPhJ_G0027987	protein coding gene	Chr4:143784504-143820573 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0027821	protein coding gene	Chr4:146488613-146503710 (-)
WSB/EiJ	MGP_WSBEiJ_G0028347	protein coding gene	Chr4:152365378-152381565 (-)

Human Ortholog

CA6, carbonic anhydrase 6

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CA6, carbonic anhydrase 6
Synonyms

CA-VI, GUSTIN
Links

HGNC:1380

NCBI Gene ID: 765

neXtProt AC: NX_P23280

UniProt: P23280
Chr Location

1p36.23; chr1:8945867-8975092 (+) GRCh38

MGI Vertebrate Homology

Car6 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: CA6
Gene Tree

Car6

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Phenotype Summary

15 phenotypes from 2 alleles in 2 genetic backgrounds
11 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

10
Endonuclease-mediated

2
Gene trapped

4
Targeted

4
Genomic Mutations

1 involving Car6
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

17 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit increase in the number of lymphoid follicles in Peyer's patches.

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All GO Annotations

11
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

861
Tissues

152
cDNA Data

924
Literature Summary

7

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase ca6

ZFIN ca6

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All Sequences

51
RefSeq

2
UniProt

9
CCDS

CCDS51386.1

Ensembl

ENSMUSG00000028972 (Evidence)
NCBI Gene

12353

			Length	Strain/Species	Flank
genomic	12353	NCBI Gene Model \| MGI Sequence Detail	14121	C57BL/6J	± kb
transcript	NM_009802	RefSeq \| MGI Sequence Detail	1380	C57BL/6
polypeptide	P18761	UniProt \| EBI \| MGI Sequence Detail	317	Not Applicable

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UniProt

9 Sequences
Protein Ontology

PR:000004923 carbonic anhydrase 6

(term hierarchy)
EC

4.2.1.1
InterPro Domains

IPR001148 Alpha carbonic anhydrase domain

IPR036398 Alpha carbonic anhydrase domain superfamily

IPR023561 Carbonic anhydrase, alpha-class
GlyGen

P18761 1 site

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All nucleic 929

cDNA 924

Primer pair 5

Microarray probesets 3

Summaries

All 45

Developmental Gene Expression 7

Gene Ontology 8

Phenotypes 11
Earliest

J:50817 Wang XZ, et al., Identification of novel stress-induced genes downstream of chop. EMBO J. 1998 Jul 1;17(13):3619-30
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Car6:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr44738	Chr4:150285582-150285598 (-)	2 bp
Tssr44737	Chr4:150282926-150282954 (-)	2,652 bp
Tssr44736	Chr4:150282676-150282687 (-)	2,910 bp
Tssr44735	Chr4:150282634-150282656 (-)	2,947 bp
Tssr44734	Chr4:150282590-150282597 (-)	2,998 bp
Tssr44733	Chr4:150281819-150281842 (-)	3,761 bp
Tssr44732	Chr4:150281812-150281817 (-)	3,777 bp
Tssr44731	Chr4:150280599-150280612 (-)	4,986 bp
Tssr44730	Chr4:150280566-150280574 (-)	5,022 bp
Tssr44729	Chr4:150280536-150280543 (-)	5,052 bp
Tssr44728	Chr4:150278215-150278232 (-)	7,368 bp
Tssr44727	Chr4:150277086-150277090 (-)	8,504 bp
Tssr44726	Chr4:150277030-150277042 (-)	8,556 bp
Tssr44725	Chr4:150276995-150277015 (-)	8,587 bp
Tssr44724	Chr4:150276968-150276973 (-)	8,621 bp
Tssr44723	Chr4:150273692-150273702 (-)	11,895 bp
Tssr44722	Chr4:150273642-150273647 (-)	11,947 bp
Tssr44721	Chr4:150273608-150273614 (-)	11,981 bp
Tssr44720	Chr4:150271847-150271854 (-)	13,741 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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