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Top3b Gene Detail
Summary
  • Symbol
    Top3b
  • Name
    topoisomerase (DNA) III beta
  • Synonyms
    Topo III beta
  • Feature Type
    protein coding gene
  • IDs
    MGI:1333803
    NCBI Gene: 21976
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:16688600-16710854 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 10.46 cM, cytoband B1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    541 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1333803
 protein coding gene Chr16:16688587-16710854 (+)
129S1/SvImJ MGP_129S1SvImJ_G0022564
 protein coding gene Chr16:13964805-13987015 (+)
A/J MGP_AJ_G0022525
 protein coding gene Chr16:13280467-13303270 (+)
AKR/J MGP_AKRJ_G0022502
 protein coding gene Chr16:13823467-13845681 (+)
BALB/cJ MGP_BALBcJ_G0022528
 protein coding gene Chr16:13432998-13455338 (+)
C3H/HeJ MGP_C3HHeJ_G0022295
 protein coding gene Chr16:13930588-13953193 (+)
C57BL/6NJ MGP_C57BL6NJ_G0022979
 protein coding gene Chr16:14183971-14207704 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0020499
 protein coding gene Chr16:13364563-13387119 (+)
CAST/EiJ MGP_CASTEiJ_G0021823
 protein coding gene Chr16:13860229-13882474 (+)
CBA/J MGP_CBAJ_G0022266
 protein coding gene Chr16:14845678-14874508 (+)
DBA/2J MGP_DBA2J_G0022396
 protein coding gene Chr16:13219353-13241800 (+)
FVB/NJ MGP_FVBNJ_G0022372
 protein coding gene Chr16:13242231-13264453 (+)
LP/J MGP_LPJ_G0022463
 protein coding gene Chr16:13752549-13775670 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0022393
 protein coding gene Chr16:14556483-14578700 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0022990
 protein coding gene Chr16:13733413-13755619 (+)
PWK/PhJ MGP_PWKPhJ_G0021566
 protein coding gene Chr16:13458514-13480984 (+)
SPRET/EiJ MGP_SPRETEiJ_G0021394
 protein coding gene Chr16:13737919-13762633 (+)
WSB/EiJ MGP_WSBEiJ_G0021870
 protein coding gene Chr16:13741891-13765302 (+)



Homology
more
  • Human Ortholog
    TOP3B, DNA topoisomerase III beta
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TOP3B, DNA topoisomerase III beta
  • Synonyms
    TOP3B1
  • Links
    NCBI Gene ID: 8940
    neXtProt AC: NX_O95985
    UniProt: O95985

  • Chr Location
    22q11.22; chr22:21957025-21982813 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    18 phenotypes from 1 allele in 1 genetic background
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice develop to maturity but die prematurely showing enlargement of lymphatic organs and glomerulonephritis. Intercrossing of mutant mice progressively results in infertility that is correlated to increased aneuploidy in germ cells.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    15
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    709
  • Tissues
    1
  • cDNA Data
    91
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000022779 Ensembl Gene Model | MGI Sequence Detail 22255 C57BL/6J ±  kb
    transcript ENSMUST00000232581 Ensembl | MGI Sequence Detail 2950 Not Applicable  
    polypeptide ENSMUSP00000156132 Ensembl | MGI Sequence Detail 862 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      11 Sequences
    • Protein Ontology
      PR:000016547 DNA topoisomerase 3-beta-1
      (term hierarchy)
    • EC
      5.6.2.1
    • InterPro Domains
      IPR034144 DNA topoisomerase 3-like, TOPRIM domain
      IPR000380 DNA topoisomerase, type IA
      IPR023406 DNA topoisomerase, type IA, active site
      IPR013497 DNA topoisomerase, type IA, central
      IPR013824 DNA topoisomerase, type IA, central region, subdomain 1
      IPR013825 DNA topoisomerase, type IA, central region, subdomain 2
      IPR013826 DNA topoisomerase, type IA, central region, subdomain 3
      IPR023405 DNA topoisomerase, type IA, core domain
      IPR003602 DNA topoisomerase, type IA, DNA-binding domain
      IPR003601 DNA topoisomerase, type IA, domain 2
      IPR036280 Multiheme cytochrome superfamily
      IPR006171 TOPRIM domain
    Molecular
    Reagents
    less
    • All nucleic 93
      cDNA 92
      Primer pair 1

      Microarray probesets 3
    References
    more
    • Summaries
      All 46
      Developmental Gene Expression 1
      Gene Ontology 8
      Phenotypes 18
    • Earliest
      J:50529 Seki T, et al., Cloning of cDNA encoding a novel mouse DNA topoisomerase III (Topo IIIbeta) possessing negatively supercoiled DNA relaxing activity, whose message is highly expressed in the testis. J Biol Chem. 1998 Oct 30;273(44):28553-6
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory