Srsf10 MGI Mouse Gene Detail - MGI:1333805 - serine and arginine-rich splicing factor 10

Symbol

Srsf10
Name

serine and arginine-rich splicing factor 10
Synonyms

Fusip1, FUSIP2, Nssr, NSSR1, NSSR2, Sfrs13a, SRrp40, Srsf13a, TASR1, TASR2

Feature Type

protein coding gene
IDs

MGI:1333805
NCBI Gene: 14105
Alliance

gene page
Transcription Start Sites

10 TSS

Sequence Map

Chr4:135583058-135597219 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 4, 68.01 cM, cytoband D3
Mapping Data

2 experiments

SNPs within 2kb

234 from dbSNP Build 142
Strain Annotations

17

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1333805	protein coding gene	Chr4:135582454-135597219 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0028950	protein coding gene	Chr4:138340842-138357268 (+)
A/J	MGP_AJ_G0028909	protein coding gene	Chr4:132471858-132486847 (+)
AKR/J	MGP_AKRJ_G0028861	protein coding gene	Chr4:136294186-136305380 (+)
BALB/cJ	MGP_BALBcJ_G0028933	protein coding gene	Chr4:133141028-133151566 (+)
C3H/HeJ	MGP_C3HHeJ_G0028647	protein coding gene	Chr4:136574644-136589463 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0029374	protein coding gene	Chr4:143250536-143263874 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0026645	protein coding gene	Chr4:125525028-125539401 (+)
CAST/EiJ	MGP_CASTEiJ_G0028079	protein coding gene	Chr4:134701779-134721324 (+)
CBA/J	MGP_CBAJ_G0028612	protein coding gene	Chr4:147184257-147194504 (+)
DBA/2J	MGP_DBA2J_G0028761	protein coding gene	Chr4:132888774-132916080 (+)
FVB/NJ	MGP_FVBNJ_G0028728	protein coding gene	Chr4:131817635-131834866 (+)
LP/J	MGP_LPJ_G0028860	protein coding gene	Chr4:138440752-138455753 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0028754	protein coding gene	Chr4:151469675-151483900 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0029412	protein coding gene	Chr4:136756466-136766875 (+)
PWK/PhJ	no annotation
SPRET/EiJ	MGP_SPRETEiJ_G0027625	protein coding gene	Chr4:132566322-132581341 (+)
WSB/EiJ	MGP_WSBEiJ_G0028157	protein coding gene	Chr4:136919610-136939025 (+)

Human Ortholog

SRSF10, serine and arginine rich splicing factor 10

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SRSF10, serine and arginine rich splicing factor 10
Synonyms

FUSIP1, FUSIP2, NSSR, PPP1R149, SFRS13, SFRS13A, SRp38, SRrp40, TASR, TASR1, TASR2
Links

HGNC:16713

NCBI Gene ID: 10772

neXtProt AC: NX_O75494

UniProt: O75494
Chr Location

1p36.11; chr1:23964347-23980927 (-) GRCh38

MGI Vertebrate Homology

Srsf10 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: SRSF10
Gene Tree

Srsf10

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Phenotype Summary

13 phenotypes from 1 allele in 1 genetic background
15 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

53
Chemically induced (other)

2
Gene trapped

47
Targeted

4
Genomic Mutations

3 involving Srsf10
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

29 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele exhibit fetal and neonatal lethality associated with edema and cardiac defects.

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All GO Annotations

29
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

858
Tissues

93
cDNA Data

26
Literature Summary

11

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA SRSF10

Xenbase srsf10

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All Sequences

84
RefSeq

14
UniProt

6
CCDS

CCDS18791.1, CCDS38922.1, CCDS71493.1, CCDS71494.1

Ensembl

ENSMUSG00000028676 (Evidence)
NCBI Gene

14105

			Length	Strain/Species	Flank
genomic	ENSMUSG00000028676	Ensembl Gene Model \| MGI Sequence Detail	14162	C57BL/6J	± kb
transcript	ENSMUST00000105853	Ensembl \| MGI Sequence Detail	3058	Not Applicable
polypeptide	ENSMUSP00000101479	Ensembl \| MGI Sequence Detail	262	Not Applicable

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UniProt

6 Sequences
Protein Ontology

PR:000007701 serine/arginine-rich splicing factor 10

(term hierarchy)
InterPro Domains

IPR012677 Nucleotide-binding alpha-beta plait domain superfamily

IPR035979 RNA-binding domain superfamily

IPR050441 RNA-binding motif

IPR000504 RNA recognition motif domain

IPR050907 Serine/Arginine-Rich Splicing Factor
GlyGen

Q9R0U0 2 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)

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All nucleic 31

cDNA 27

Primer pair 4

Microarray probesets 8

Summaries

All 52

Developmental Gene Expression 11

Gene Ontology 8

Phenotypes 15
Earliest

J:51309 Yang L, et al., Oncoprotein TLS interacts with serine-arginine proteins involved in RNA splicing. J Biol Chem. 1998 Oct 23;273(43):27761-4
Latest

J:351034 Ma A, et al., SRSF10 regulates migration of neural progenitor cells and granule cells and affects the formation of dentate gyrus during the development of mouse hippocampus. Neuroscience. 2024 Jul 1;

TSS for Srsf10:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr39638	Chr4:135583018-135583055 (+)	-21 bp
Tssr39639	Chr4:135583398-135583435 (+)	359 bp
Tssr39640	Chr4:135583439-135583471 (+)	397 bp
Tssr39641	Chr4:135583553-135583562 (+)	500 bp
Tssr39642	Chr4:135583947-135583991 (+)	911 bp
Tssr39643	Chr4:135585197-135585201 (+)	2,141 bp
Tssr39644	Chr4:135586511-135586516 (+)	3,456 bp
Tssr39645	Chr4:135589074-135589076 (+)	6,017 bp
Tssr39646	Chr4:135590272-135590276 (+)	7,216 bp
Tssr39647	Chr4:135595936-135595949 (+)	12,885 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/17/2024 MGI 6.24