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Cx3cr1 Gene Detail
Summary
  • Symbol
    Cx3cr1
  • Name
    C-X3-C motif chemokine receptor 1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1333815
    NCBI Gene: 13051
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:119877749-119897362 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 71.37 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    693 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1333815
 protein coding gene Chr9:119877749-119898945 (-)
129S1/SvImJ MGP_129S1SvImJ_G0035425
 protein coding gene Chr9:122709292-122887632 (-)
A/J MGP_AJ_G0035406
 protein coding gene Chr9:118114428-118288047 (-)
AKR/J MGP_AKRJ_G0035343
 protein coding gene Chr9:121357823-121375403 (-)
BALB/cJ MGP_BALBcJ_G0035406
 protein coding gene Chr9:118153098-118172355 (-)
C3H/HeJ MGP_C3HHeJ_G0035114
 protein coding gene Chr9:121830939-121853647 (-)
C57BL/6NJ MGP_C57BL6NJ_G0035929
 protein coding gene Chr9:126232232-126249320 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0032807
 protein coding gene Chr9:115319102-115487836 (-)
CAST/EiJ MGP_CASTEiJ_G0034414
 protein coding gene Chr9:121682904-121870213 (-)
CBA/J MGP_CBAJ_G0035081
 protein coding gene Chr9:130935282-130960698 (-)
DBA/2J MGP_DBA2J_G0035240
 protein coding gene Chr9:117713310-117733849 (-)
FVB/NJ MGP_FVBNJ_G0035187
 protein coding gene Chr9:116592947-116611177 (-)
LP/J MGP_LPJ_G0035319
 protein coding gene Chr9:123196965-123220368 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0035224
 protein coding gene Chr9:131716141-131895106 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0035944
 protein coding gene Chr9:121597477-121773039 (-)
PWK/PhJ MGP_PWKPhJ_G0034119
 protein coding gene Chr9:118001590-118174193 (-)
SPRET/EiJ MGP_SPRETEiJ_G0033955
 protein coding gene Chr9:121682819-121878857 (-)
WSB/EiJ MGP_WSBEiJ_G0034534
 protein coding gene Chr9:121482064-121660660 (-)



Homology
more
  • Human Ortholog
    CX3CR1, C-X3-C motif chemokine receptor 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CX3CR1, C-X3-C motif chemokine receptor 1
  • Synonyms
    CCRL1, CMKBRL1, CMKDR1, GPR13, GPRV28, V28
  • Links
    NCBI Gene ID: 1524
    neXtProt AC: NX_P49238
    UniProt: P49238

  • Chr Location
    3p22.2; chr3:39263494-39292966 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Cx3cr1 mouse models; 10 with human CX3CR1 associations

Human Disease Mouse Models
      
IDs
 View 2 models
      
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    51 phenotypes from 4 alleles in 10 genetic backgrounds
    50 phenotypes from multigenic genotypes
    4 images
    1552 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Age related retinal degeneration with abnormal subretinal microglial cell accumulation in one homozygous null mice. Other null mice shows impaired monocyte recruitment after vascular injury, kidney ischemia and reperfusion, and bacterial infection of the instestine.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    95
  • GO References
    16
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    870
  • Tissues
    66
  • cDNA Data
    9
  • Literature Summary
    59
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 13051 NCBI Gene Model | MGI Sequence Detail 19614 C57BL/6J ±  kb
    transcript NM_009987 RefSeq | MGI Sequence Detail 3753 C57BL/6  
    polypeptide Q9Z0D9 UniProt | EBI | MGI Sequence Detail 354 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 11
      Genomic 1
      cDNA 9
      Primer pair 1

      Microarray probesets 5
    References
    more
    • Summaries
      All 1640
      Developmental Gene Expression 59
      Diseases 3
      Gene Ontology 16
      Phenotypes 1552
    • Earliest
      J:51793 Combadiere C, et al., Gene cloning, RNA distribution, and functional expression of mCX3CR1, a mouse chemotactic receptor for the CX3C chemokine fractalkine. Biochem Biophys Res Commun. 1998 Dec 30;253(3):728-32
    • Latest
      J:358308 Rodriguez D, et al., Fractalkine isoforms differentially regulate microglia-mediated inflammation and enhance visual function in the diabetic retina. J Neuroinflammation. 2024 Feb 4;21(1):42
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory