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Dgat1 Gene Detail
Summary
  • Symbol
    Dgat1
  • Name
    diacylglycerol O-acyltransferase 1
  • Synonyms
    D15Ertd23e
  • Feature Type
    protein coding gene
  • IDs
    MGI:1333825
    NCBI Gene: 13350
  • Alliance
    gene page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:76386215-76396153 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 35.99 cM
  • Mapping Data
    7 experiments
Strain
Comparison
more
  • SNPs within 2kb
    170 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1333825
 protein coding gene Chr15:76386215-76396167 (-)
129S1/SvImJ MGP_129S1SvImJ_G0021995
 protein coding gene Chr15:76580003-76589946 (-)
A/J MGP_AJ_G0021953
 protein coding gene Chr15:73791475-73801384 (-)
AKR/J MGP_AKRJ_G0021936
 protein coding gene Chr15:75792490-75802428 (-)
BALB/cJ MGP_BALBcJ_G0021962
 protein coding gene Chr15:73819659-73829567 (-)
C3H/HeJ MGP_C3HHeJ_G0021734
 protein coding gene Chr15:75840498-75850408 (-)
C57BL/6NJ MGP_C57BL6NJ_G0022402
 protein coding gene Chr15:79444169-79454032 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019931
 protein coding gene Chr15:70455226-70465169 (-)
CAST/EiJ MGP_CASTEiJ_G0021253
 protein coding gene Chr15:76642298-76652209 (-)
CBA/J MGP_CBAJ_G0021701
 protein coding gene Chr15:81954631-81964538 (-)
DBA/2J MGP_DBA2J_G0021826
 protein coding gene Chr15:73328047-73337999 (-)
FVB/NJ MGP_FVBNJ_G0021806
 protein coding gene Chr15:72384505-72394414 (-)
LP/J MGP_LPJ_G0021897
 protein coding gene Chr15:76678684-76688596 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0021831
 protein coding gene Chr15:87284325-87295126 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0022422
 protein coding gene Chr15:76045706-76055614 (-)
PWK/PhJ MGP_PWKPhJ_G0020994
 protein coding gene Chr15:73493850-73503891 (-)
SPRET/EiJ MGP_SPRETEiJ_G0020834
 protein coding gene Chr15:75759865-75769817 (-)
WSB/EiJ MGP_WSBEiJ_G0021305
 protein coding gene Chr15:76150364-76160314 (-)



Homology
more
  • Human Ortholog
    DGAT1, diacylglycerol O-acyltransferase 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DGAT1, diacylglycerol O-acyltransferase 1
  • Synonyms
    ARAT, ARGP1, DGAT, DIAR7
  • Links
    NCBI Gene ID: 8694
    neXtProt AC: NX_O75907
    UniProt: O75907

  • Chr Location
    8q24.3; chr8:144314584-144326910 (-)  GRCh38
Human Diseases
more
  • Diseases
    2 with human DGAT1 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    38 phenotypes from 3 alleles in 4 genetic backgrounds
    14 phenotypes from multigenic genotypes
    5 images
    77 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous inactivation of this gene leads to decreased percent body fat, resistance to diet-induced obesity, altered energy, glucose and triglyceride metabolism, alopecia, hair cycle and skin defects, and a lactation failure associated with impaired mammary gland growth during pregnancy.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    45
  • GO References
    17
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    825
  • Tissues
    112
  • cDNA Data
    64
  • Literature Summary
    8
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000022555 Ensembl Gene Model | MGI Sequence Detail 9939 C57BL/6J ±  kb
    transcript ENSMUST00000023214 Ensembl | MGI Sequence Detail 1888 Not Applicable  
    polypeptide ENSMUSP00000023214 Ensembl | MGI Sequence Detail 498 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 70
      cDNA 64
      Primer pair 6

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:1098564, MGI:2139452
    References
    more
    • Summaries
      All 141
      Developmental Gene Expression 8
      Diseases 1
      Gene Ontology 17
      Phenotypes 77
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:358292 Chitraju C, et al., Mice lacking triglyceride synthesis enzymes in adipose tissue are resistant to diet-induced obesity. Elife. 2023 Oct 2;12
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory