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Itln1 Gene Detail
Summary
  • Symbol
    Itln1
  • Name
    intelectin 1 (galactofuranose binding)
  • Synonyms
    IntL, Itln2, Itlna, mLfR
  • Feature Type
    protein coding gene
  • IDs
    MGI:1333831
    NCBI Gene: 16429
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:171345690-171362862 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 79.49 cM, cytoband H2
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    541 from dbSNP Build 142
  • Strain Annotations
    7
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1333831
 protein coding gene Chr1:171345690-171362893 (-)
129S1/SvImJ MGP_129S1SvImJ_G0016765
 protein coding gene Chr1:177332322-177340062 (-)
A/J no annotation
AKR/J no annotation
BALB/cJ no annotation
C3H/HeJ MGP_C3HHeJ_G0016529
 protein coding gene Chr1:175629526-175790836 (-)
C57BL/6NJ MGP_C57BL6NJ_G0017167
 protein coding gene Chr1:183222739-183235039 (-)
CAROLI/EiJ no annotation
CAST/EiJ MGP_CASTEiJ_G0016110
 protein coding gene Chr1:175069794-175088559 (-)
CBA/J no annotation
DBA/2J no annotation
FVB/NJ MGP_FVBNJ_G0016607
 protein coding gene Chr1:167297253-167301349 (-)
LP/J no annotation
NOD/ShiLtJ MGP_NODShiLtJ_G0016634
 protein coding gene Chr1:196995668-197006005 (-)
NZO/HlLtJ no annotation
PWK/PhJ no annotation
SPRET/EiJ no annotation
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    ITLN1, intelectin 1
  • Vertebrate Orthologs
    10
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ITLN1, intelectin 1
  • Synonyms
    hIntL, HL-1, HL1, INTL, ITLN, LFR, omentin
  • Links
    NCBI Gene ID: 55600
    neXtProt AC: NX_Q8WWA0
    UniProt: Q8WWA0

  • Chr Location
    1q23.3; chr1:160876540-160885180 (-)  GRCh38
  • Human Ortholog
    ITLN2, intelectin 2
  • Synonyms
    HL-2, HL2
  • Links
    NCBI Gene ID: 142683
    neXtProt AC: NX_Q8WWU7
    UniProt: Q8WWU7

  • Chr Location
    1q23.3; chr1:160945025-160954809 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    18 phenotypes from 2 alleles in 2 genetic backgrounds
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit inflammatory bone loss-like phenotypes including increased proinflammatory cytokine levels, increased osteoclast formation and bone tissue destruction, decreased osteoblast proliferation and enhanced proliferation of osteoclast progenitors.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    17
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    788
  • Tissues
    62
  • cDNA Data
    5
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000038209 Ensembl Gene Model | MGI Sequence Detail 17173 C57BL/6J ±  kb
    transcript ENSMUST00000043094 Ensembl | MGI Sequence Detail 1141 Not Applicable  
    polypeptide ENSMUSP00000043837 Ensembl | MGI Sequence Detail 313 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      5 Sequences
    • Protein Ontology
      PR:000033904 intelectin-1a
      (term hierarchy)
    • InterPro Domains
      IPR002181 Fibrinogen, alpha/beta/gamma chain, C-terminal globular domain
      IPR014716 Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1
      IPR036056 Fibrinogen-like, C-terminal
    Molecular
    Reagents
    less
    • All nucleic 8
      Genomic 2
      cDNA 5
      Primer pair 1

      Microarray probesets 3
    References
    more
    • Summaries
      All 53
      Developmental Gene Expression 3
      Gene Ontology 11
      Phenotypes 15
    • Earliest
      J:50538 Komiya T, et al., Cloning of the novel gene intelectin, which is expressed in intestinal paneth cells in mice. Biochem Biophys Res Commun. 1998 Oct 29;251(3):759-62
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory