Grap2 MGI Mouse Gene Detail - MGI:1333842 - GRB2-related adaptor protein 2

Symbol

Grap2
Name

GRB2-related adaptor protein 2
Synonyms

Gads, GRAP-2, GRB2L, Grb2-related adaptor downstream of Sch, GrbX, Grf40, GRID, GrpL, Mona, P38

Feature Type

protein coding gene
IDs

MGI:1333842
NCBI Gene: 17444
Alliance

gene page
Transcription Start Sites

18 TSS

Sequence Map

Chr15:80456798-80537055 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 15, 37.88 cM, cytoband E2
Mapping Data

2 experiments

SNPs within 2kb

1834 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1333842	protein coding gene	Chr15:80456795-80537055 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0022101	protein coding gene	Chr15:80983547-81018706 (+)
A/J	MGP_AJ_G0022062	protein coding gene	Chr15:78161464-78189419 (+)
AKR/J	MGP_AKRJ_G0022037	protein coding gene	Chr15:80353964-80380988 (+)
BALB/cJ	MGP_BALBcJ_G0022068	protein coding gene	Chr15:78169851-78198363 (+)
C3H/HeJ	MGP_C3HHeJ_G0021839	protein coding gene	Chr15:80339454-80368901 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0022511	protein coding gene	Chr15:84174000-84203281 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0020041	protein coding gene	Chr15:74646619-74673420 (+)
CAST/EiJ	MGP_CASTEiJ_G0021360	protein coding gene	Chr15:81072139-81100087 (+)
CBA/J	MGP_CBAJ_G0021804	protein coding gene	Chr15:86819131-86849842 (+)
DBA/2J	MGP_DBA2J_G0021933	protein coding gene	Chr15:77657703-77685158 (+)
FVB/NJ	MGP_FVBNJ_G0021911	protein coding gene	Chr15:76691207-76718364 (+)
LP/J	MGP_LPJ_G0022001	protein coding gene	Chr15:81159754-81190049 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0021931	protein coding gene	Chr15:91824939-91856700 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0022525	protein coding gene	Chr15:80393378-80422454 (+)
PWK/PhJ	MGP_PWKPhJ_G0021102	protein coding gene	Chr15:77665512-77693119 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0020939	protein coding gene	Chr15:80192309-80220456 (+)
WSB/EiJ	MGP_WSBEiJ_G0021412	protein coding gene	Chr15:80802140-80831091 (+)

Human Ortholog

GRAP2, GRB2 related adaptor protein 2

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

GRAP2, GRB2 related adaptor protein 2
Synonyms

GADS, GRAP-2, GRB2L, GRBLG, GrbX, Grf40, GRID, GRPL, Mona, P38
Links

HGNC:4563

NCBI Gene ID: 9402

neXtProt AC: NX_O75791

UniProt: O75791
Chr Location

22q13.1; chr22:39893820-39973721 (+) GRCh38

MGI Vertebrate Homology

Grap2 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: GRAP2
Gene Tree

Grap2

Diseases

1 with human GRAP2 associations

				Human Disease	Mouse Models
				hepatitis C IDs hepatitis C DOID:1883 DOID:12430 DOID:12432 DOID:2049 EFO:0003047 ICD10CM:B19.20 ICD9CM:070.7 MESH:D006526 NCI:C3098 UMLS_CUI:C0019196

Click on a disease name to see all genes associated with that disease.

References

1 with disease annotations

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Phenotype Summary

10 phenotypes from 2 alleles in 2 genetic backgrounds
5 phenotypes from multigenic genotypes
39 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

9
Chemically induced (other)

1
Endonuclease-mediated

2
Radiation induced

2
Targeted

4
Genomic Mutations

3 involving Grap2
Incidental Mutations

APF , CvDC
Find Mice (IMSR)

23 strains or lines available

Mice homozygous for disruptions in this gene are grossly healthy but display abnormal T cell development.

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All GO Annotations

24
GO References

9

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

756
Tissues

19
cDNA Data

21
Literature Summary

3

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase grap2

ZFIN grap2a, grap2b

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All Sequences

47
RefSeq

4
UniProt

4
CCDS

CCDS27663.1

Ensembl

ENSMUSG00000042351 (Evidence)
NCBI Gene

17444

			Length	Strain/Species	Flank
genomic	17444	NCBI Gene Model \| MGI Sequence Detail	80258	C57BL/6J	± kb
transcript	NM_010815	RefSeq \| MGI Sequence Detail	5475	C57BL/6
polypeptide	O89100	UniProt \| EBI \| MGI Sequence Detail	322	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000008220 GRB2-related adapter protein 2

(term hierarchy)
PDB

1H3H, 1OEB, 1R1P, 1R1Q, 1R1S, 1UTI, 2D0N, 2W10
InterPro Domains

IPR035646 GRAP2, C-terminal SH3 domain

IPR043539 Grb2-like

IPR000980 SH2 domain

IPR036860 SH2 domain superfamily

IPR001452 SH3 domain

IPR036028 SH3-like domain superfamily

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All nucleic 24

cDNA 22

Primer pair 2

Microarray probesets 4

Summaries

All 77

Developmental Gene Expression 3

Diseases 1

Gene Ontology 9

Phenotypes 39
Earliest

J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
Latest

J:285676 Suzuki A, et al., Genes and microRNAs associated with mouse cleft palate: A systematic review and bioinformatics analysis. Mech Dev. 2018 Apr;150:21-27

TSS for Grap2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr132215	Chr15:80456625-80456636 (+)	-167 bp
Tssr132216	Chr15:80456656-80456661 (+)	-139 bp
Tssr132217	Chr15:80456670-80456681 (+)	-122 bp
Tssr132218	Chr15:80456695-80456700 (+)	-100 bp
Tssr132219	Chr15:80456738-80456761 (+)	-48 bp
Tssr132220	Chr15:80456777-80456802 (+)	-8 bp
Tssr132221	Chr15:80456807-80456818 (+)	15 bp
Tssr132222	Chr15:80456875-80456882 (+)	81 bp
Tssr132223	Chr15:80456883-80456893 (+)	90 bp
Tssr132224	Chr15:80456913-80456914 (+)	116 bp
Tssr132225	Chr15:80457002-80457026 (+)	216 bp
Tssr132226	Chr15:80462568-80462592 (+)	5,782 bp
Tssr132227	Chr15:80481921-80481966 (+)	25,146 bp
Tssr132228	Chr15:80482066-80482076 (+)	25,273 bp
Tssr132229	Chr15:80495954-80495968 (+)	39,163 bp
Tssr132230	Chr15:80507543-80507555 (+)	50,751 bp
Tssr132231	Chr15:80507671-80507692 (+)	50,884 bp
Tssr132232	Chr15:80507700-80507750 (+)	50,927 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24