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Atox1 Gene Detail
Summary
  • Symbol
    Atox1
  • Name
    antioxidant 1 copper chaperone
  • Synonyms
    ATX1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1333855
    NCBI Gene: 11927
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:55337463-55352034 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 33.07 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    510 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1333855
 protein coding gene Chr11:55337463-55352065 (-)
129S1/SvImJ MGP_129S1SvImJ_G0018331
 protein coding gene Chr11:54976996-54993060 (-)
A/J MGP_AJ_G0018300
 protein coding gene Chr11:52932127-52946760 (-)
AKR/J MGP_AKRJ_G0018269
 protein coding gene Chr11:54656198-54671843 (-)
BALB/cJ MGP_BALBcJ_G0018271
 protein coding gene Chr11:53257662-53272430 (-)
C3H/HeJ MGP_C3HHeJ_G0018082
 protein coding gene Chr11:54592494-54607074 (-)
C57BL/6NJ MGP_C57BL6NJ_G0018723
 protein coding gene Chr11:56644815-56659148 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0016373
 protein coding gene Chr11:50350200-50364029 (-)
CAST/EiJ MGP_CASTEiJ_G0017647
 protein coding gene Chr11:54633826-54648824 (-)
CBA/J MGP_CBAJ_G0018057
 protein coding gene Chr11:59338293-59354891 (-)
DBA/2J MGP_DBA2J_G0018166
 protein coding gene Chr11:52613998-52628718 (-)
FVB/NJ MGP_FVBNJ_G0018158
 protein coding gene Chr11:52280737-52296421 (-)
LP/J MGP_LPJ_G0018241
 protein coding gene Chr11:55438713-55455555 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0018184
 protein coding gene Chr11:60513416-60527964 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0018765
 protein coding gene Chr11:54678460-54694555 (-)
PWK/PhJ MGP_PWKPhJ_G0017420
 protein coding gene Chr11:53189111-53203974 (-)
SPRET/EiJ MGP_SPRETEiJ_G0017215
 protein coding gene Chr11:54470640-54484045 (-)
WSB/EiJ MGP_WSBEiJ_G0017695
 protein coding gene Chr11:54321373-54337010 (-)



Homology
more
  • Human Ortholog
    ATOX1, antioxidant 1 copper chaperone
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ATOX1, antioxidant 1 copper chaperone
  • Synonyms
    ATX1, HAH1
  • Links
    NCBI Gene ID: 475
    neXtProt AC: NX_O00244
    UniProt: O00244

  • Chr Location
    5q33.1; chr5:151742316-151772532 (-)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    18 phenotypes from 1 allele in 1 genetic background
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a targeted null mutation have impaired intracellular copper trafficking and exhibit high postnatal mortality, retarded growth, hypoactivity, loose skin, hypopigmentation, and seizures.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    16
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    707
  • Tissues
    1
  • cDNA Data
    88
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 11927 NCBI Gene Model | MGI Sequence Detail 14572 C57BL/6J ±  kb
    transcript NM_009720 RefSeq | MGI Sequence Detail 532 ZRU/MplStud  
    polypeptide O08997 UniProt | EBI | MGI Sequence Detail 68 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 88
      cDNA 88

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:2144096
    References
    more
    • Summaries
      All 53
      Developmental Gene Expression 2
      Diseases 1
      Gene Ontology 5
      Phenotypes 18
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:344347 Sudhahar V, et al., Whole-Transcriptome Sequencing Analyses of Nuclear Antixoxidant-1 in Endothelial Cells: Role in Inflammation and Atherosclerosis. Cells. 2022 Sep 18;11(18)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory