Ch25h MGI Mouse Gene Detail - MGI:1333869 - cholesterol 25-hydroxylase

Symbol

Ch25h
Name

cholesterol 25-hydroxylase
Synonyms

m25OH

Feature Type

protein coding gene
IDs

MGI:1333869
NCBI Gene: 12642
Alliance

gene page
Transcription Start Sites

1 TSS

Sequence Map

Chr19:34451183-34452548 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 19, 29.69 cM
Mapping Data

1 experiment

SNPs within 2kb

178 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1333869	protein coding gene	Chr19:34451178-34452564 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0025057	protein coding gene	Chr19:33216601-33217950 (-)
A/J	MGP_AJ_G0025035	protein coding gene	Chr19:31604942-31606291 (-)
AKR/J	MGP_AKRJ_G0025001	protein coding gene	Chr19:32670810-32672159 (-)
BALB/cJ	MGP_BALBcJ_G0025031	protein coding gene	Chr19:31717567-31718916 (-)
C3H/HeJ	MGP_C3HHeJ_G0024790	protein coding gene	Chr19:32768238-32769587 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0025472	protein coding gene	Chr19:34167419-34168768 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0022890	protein coding gene	Chr19:31046273-31047621 (-)
CAST/EiJ	MGP_CASTEiJ_G0024260	protein coding gene	Chr19:32518908-32520252 (-)
CBA/J	MGP_CBAJ_G0024767	protein coding gene	Chr19:35774809-35776158 (-)
DBA/2J	MGP_DBA2J_G0024899	protein coding gene	Chr19:31506423-31507772 (-)
FVB/NJ	MGP_FVBNJ_G0024860	protein coding gene	Chr19:31349104-31350453 (-)
LP/J	MGP_LPJ_G0024985	protein coding gene	Chr19:33302198-33303547 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0024891	protein coding gene	Chr19:35558162-35559511 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0025530	protein coding gene	Chr19:32775607-32776956 (-)
PWK/PhJ	MGP_PWKPhJ_G0024009	protein coding gene	Chr19:31316686-31318035 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0023810	protein coding gene	Chr19:31626266-31627614 (-)
WSB/EiJ	MGP_WSBEiJ_G0024324	protein coding gene	Chr19:32844776-32846125 (-)

Human Ortholog

CH25H, cholesterol 25-hydroxylase

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CH25H, cholesterol 25-hydroxylase
Synonyms

C25H
Links

HGNC:1907

NCBI Gene ID: 9023

neXtProt AC: NX_O95992

UniProt: O95992
Chr Location

10q23.31; chr10:89205629-89207317 (-) GRCh38

MGI Vertebrate Homology

Ch25h stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: CH25H
Gene Tree

Ch25h

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Phenotype Summary

7 phenotypes from 2 alleles in 2 genetic backgrounds
52 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

10
Endonuclease-mediated

6
Targeted

4
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

22 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit increased IgG2a and IgA in the sera, lungs, and intestinal mucosa and increased IgG2b and IgG3 in the intestinal mucosa.

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All GO Annotations

21
GO References

9

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

877
Tissues

127
cDNA Data

15
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase ch25h

ZFIN ch25h

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All Sequences

31
RefSeq

2
UniProt

1
CCDS

CCDS29759.1

Ensembl

ENSMUSG00000050370 (Evidence)
NCBI Gene

12642

			Length	Strain/Species	Flank
genomic	12642	NCBI Gene Model \| MGI Sequence Detail	1366	C57BL/6J	± kb
transcript	NM_009890	RefSeq \| MGI Sequence Detail	1366	C57BL/6
polypeptide	Q9Z0F5	UniProt \| EBI \| MGI Sequence Detail	298	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000005397 cholesterol 25-hydroxylase

(term hierarchy)
EC

1.14.99.38
InterPro Domains

IPR006694 Fatty acid hydroxylase

IPR050307 Sterol Desaturase and Related Enzymes
GlyGen

Q9Z0F5 2 sites

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All nucleic 16

Genomic 1

cDNA 15

Microarray probesets 3

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MGI:2147554

Summaries

All 82

Developmental Gene Expression 2

Gene Ontology 9

Phenotypes 52
Earliest

J:51514 Lund EG, et al., cDNA cloning of mouse and human cholesterol 25-hydroxylases, polytopic membrane proteins that synthesize a potent oxysterol regulator of lipid metabolism. J Biol Chem. 1998 Dec 18;273(51):34316-27
Latest

J:355384 Toral-Rios D, et al., Cholesterol 25-hydroxylase mediates neuroinflammation and neurodegeneration in a mouse model of tauopathy. J Exp Med. 2024 Apr 1;221(4)

TSS for Ch25h:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr158952	Chr19:34452543-34452551 (-)	1 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/05/2024 MGI 6.24