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Gpr50 Gene Detail
Summary
  • Symbol
    Gpr50
  • Name
    G-protein-coupled receptor 50
  • Synonyms
    H9
  • Feature Type
    protein coding gene
  • IDs
    MGI:1333877
    NCBI Gene: 14765
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:70707273-70712863 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome X, 36.98 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    129 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1333877
 protein coding gene ChrX:70707273-70712863 (+)
129S1/SvImJ MGP_129S1SvImJ_G0035784
 protein coding gene ChrX:67322991-67328548 (+)
A/J MGP_AJ_G0035768
 protein coding gene ChrX:67575416-67580889 (+)
AKR/J MGP_AKRJ_G0035690
 protein coding gene ChrX:69369986-69375546 (+)
BALB/cJ MGP_BALBcJ_G0035755
 protein coding gene ChrX:66636440-66642003 (+)
C3H/HeJ MGP_C3HHeJ_G0035458
 protein coding gene ChrX:67841151-67846714 (+)
C57BL/6NJ MGP_C57BL6NJ_G0036285
 protein coding gene ChrX:69372078-69380395 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0033132
 protein coding gene ChrX:66814241-66819799 (+)
CAST/EiJ MGP_CASTEiJ_G0034750
 protein coding gene ChrX:53229838-53241226 (+)
CBA/J MGP_CBAJ_G0035433
 protein coding gene ChrX:71312189-71319548 (+)
DBA/2J MGP_DBA2J_G0035586
 protein coding gene ChrX:67059927-67066948 (+)
FVB/NJ MGP_FVBNJ_G0035537
 protein coding gene ChrX:66418424-66423892 (+)
LP/J MGP_LPJ_G0035675
 protein coding gene ChrX:68180408-68199656 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0035572
 protein coding gene ChrX:73827375-73833885 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0036306
 protein coding gene ChrX:67186340-67192134 (+)
PWK/PhJ MGP_PWKPhJ_G0034450
 protein coding gene ChrX:51265373-51270931 (+)
SPRET/EiJ MGP_SPRETEiJ_G0034285
 protein coding gene ChrX:54155366-54166769 (+)
WSB/EiJ MGP_WSBEiJ_G0034892
 protein coding gene ChrX:66515040-66522150 (+)



Homology
more
  • Human Ortholog
    GPR50, G protein-coupled receptor 50
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GPR50, G protein-coupled receptor 50
  • Synonyms
    H9, Mel1c
  • Links
    NCBI Gene ID: 9248
    neXtProt AC: NX_Q13585
    UniProt: Q13585

  • Chr Location
    Xq28; chrX:151176584-151182856 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 1 allele in 1 genetic background
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a targeted disruption of this gene display alterations in energy balance and metabolism.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    11
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    933
  • Tissues
    157
  • cDNA Data
    9
  • Literature Summary
    10
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 14765 NCBI Gene Model | MGI Sequence Detail 5591 C57BL/6J ±  kb
transcript NM_010340 RefSeq | MGI Sequence Detail 3086 ZRU/MplStud  
polypeptide O88495 UniProt | EBI | MGI Sequence Detail 591 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 13
    cDNA 10
    Primer pair 3

    Microarray probesets 5
References
more
  • Summaries
    All 52
    Developmental Gene Expression 10
    Gene Ontology 7
    Phenotypes 14
  • Earliest
    J:52873 Gubitz AK, et al., Assignment of the melatonin-related receptor to human chromosome X (GPR50) and mouse chromosome X (Gpr50). Genomics. 1999 Jan 15;55(2):248-51
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory