About   Help   FAQ
Xirp1 Gene Detail
Summary
  • Symbol
    Xirp1
  • Name
    xin actin-binding repeat containing 1
  • Synonyms
    Cmya1, mXin alpha, Xin
  • Feature Type
    protein coding gene
  • IDs
    MGI:1333878
    NCBI Gene: 22437
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:119842821-119852660 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 71.36 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    328 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1333878
 protein coding gene Chr9:119842821-119852664 (-)
129S1/SvImJ MGP_129S1SvImJ_G0035429
 protein coding gene Chr9:122828034-122837877 (-)
A/J MGP_AJ_G0035410
 protein coding gene Chr9:118233246-118243080 (-)
AKR/J MGP_AKRJ_G0035342
 protein coding gene Chr9:121322936-121332770 (-)
BALB/cJ MGP_BALBcJ_G0035405
 protein coding gene Chr9:118117365-118127199 (-)
C3H/HeJ MGP_C3HHeJ_G0035113
 protein coding gene Chr9:121792844-121803879 (-)
C57BL/6NJ MGP_C57BL6NJ_G0035928
 protein coding gene Chr9:126197340-126207183 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0032811
 protein coding gene Chr9:115434705-115444543 (-)
CAST/EiJ MGP_CASTEiJ_G0034418
 protein coding gene Chr9:121810097-121819929 (-)
CBA/J MGP_CBAJ_G0035080
 protein coding gene Chr9:130900381-130910215 (-)
DBA/2J MGP_DBA2J_G0035239
 protein coding gene Chr9:117678161-117687995 (-)
FVB/NJ MGP_FVBNJ_G0035186
 protein coding gene Chr9:116557308-116567142 (-)
LP/J MGP_LPJ_G0035318
 protein coding gene Chr9:123162016-123171859 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0035228
 protein coding gene Chr9:131838804-131848647 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0035948
 protein coding gene Chr9:121716301-121726144 (-)
PWK/PhJ MGP_PWKPhJ_G0034123
 protein coding gene Chr9:118119424-118129336 (-)
SPRET/EiJ MGP_SPRETEiJ_G0033959
 protein coding gene Chr9:121817293-121827091 (-)
WSB/EiJ MGP_WSBEiJ_G0034538
 protein coding gene Chr9:121605375-121615209 (-)



Homology
more
  • Human Ortholog
    XIRP1, xin actin binding repeat containing 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    XIRP1, xin actin binding repeat containing 1
  • Synonyms
    CMYA1, Xin
  • Links
    NCBI Gene ID: 165904
    neXtProt AC: NX_Q702N8
    UniProt: Q702N8

  • Chr Location
    3p22.2; chr3:39183210-39192596 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Xirp1 mouse models

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    28 phenotypes from 2 alleles in 2 genetic backgrounds
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mice exhibit cardiac hypertrophy and a disruption of cardiac intercalated disc structure and myofilament abnormalities.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    20
  • GO References
    13
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    730
  • Tissues
    17
  • cDNA Data
    15
  • Literature Summary
    7
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 22437 NCBI Gene Model | MGI Sequence Detail 9840 C57BL/6J ±  kb
    transcript NM_011724 RefSeq | MGI Sequence Detail 5807 C57BL/6  
    polypeptide O70373 UniProt | EBI | MGI Sequence Detail 1129 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • Protein Ontology
      PR:000017479 Xin actin-binding repeat-containing protein 1
      (term hierarchy)
    • InterPro Domains
      IPR012510 Actin-binding, Xin repeat
      IPR030072 Xin actin-binding repeat-containing protein 1/2
    • GlyGen
      O70373 1 site, 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 18
      cDNA 16
      Primer pair 1
      Other 1

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGI:2143034
    References
    more
    • Summaries
      All 37
      Developmental Gene Expression 7
      Diseases 1
      Gene Ontology 13
      Phenotypes 10
    • Earliest
      J:52598 Wang DZ, et al., Requirement of a novel gene, Xin, in cardiac morphogenesis. Development. 1999 Mar;126(6):1281-94
    • Latest
      J:339824 Li C, et al., Effects of CMYA1 overexpression on cardiac structure and function in mice. Acta Biochim Biophys Sin (Shanghai). 2021 Apr 15;53(5):593-600
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory