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Grpel1 Gene Detail
Summary
  • Symbol
    Grpel1
  • Name
    GrpE-like 1, mitochondrial
  • Synonyms
    mt-GrpE#1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1334417
    NCBI Gene: 17713
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:36622529-36631421 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 19.14 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    199 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1334417
 protein coding gene Chr5:36622342-36631424 (+)
129S1/SvImJ MGP_129S1SvImJ_G0029488
 protein coding gene Chr5:34797980-34807101 (+)
A/J MGP_AJ_G0029455
 protein coding gene Chr5:33658171-33667176 (+)
AKR/J MGP_AKRJ_G0029404
 protein coding gene Chr5:34925926-34935009 (+)
BALB/cJ MGP_BALBcJ_G0029465
 protein coding gene Chr5:34166303-34175308 (+)
C3H/HeJ MGP_C3HHeJ_G0029187
 protein coding gene Chr5:34947269-34956274 (+)
C57BL/6NJ MGP_C57BL6NJ_G0029919
 protein coding gene Chr5:36708365-36717198 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0027156
 protein coding gene Chr5:31403445-31412022 (+)
CAST/EiJ MGP_CASTEiJ_G0028596
 protein coding gene Chr5:34060398-34076118 (+)
CBA/J MGP_CBAJ_G0029155
 protein coding gene Chr5:37585515-37594520 (+)
DBA/2J MGP_DBA2J_G0029303
 protein coding gene Chr5:33796663-33805668 (+)
FVB/NJ MGP_FVBNJ_G0029262
 protein coding gene Chr5:33276301-33285306 (+)
LP/J MGP_LPJ_G0029388
 protein coding gene Chr5:35247659-35256780 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0029292
 protein coding gene Chr5:38345083-38354088 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0029952
 protein coding gene Chr5:34428024-34437145 (+)
PWK/PhJ MGP_PWKPhJ_G0028321
 protein coding gene Chr5:32970038-32982048 (+)
SPRET/EiJ MGP_SPRETEiJ_G0028152
 protein coding gene Chr5:33896272-33908121 (+)
WSB/EiJ MGP_WSBEiJ_G0028677
 protein coding gene Chr5:34512944-34521946 (+)



Homology
more
  • Human Ortholog
    GRPEL1, GrpE like 1, mitochondrial
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GRPEL1, GrpE like 1, mitochondrial
  • Synonyms
    GrpE, HMGE, mt-GrpE#1
  • Links
    NCBI Gene ID: 80273
    neXtProt AC: NX_Q9HAV7
    UniProt: Q9HAV7

  • Chr Location
    4p16.1; chr4:7058671-7068085 (-)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotypes from 2 alleles in 2 genetic backgrounds
    30 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit embryonic lethality prior to E8.5. Mice homozygous for a conditional allele activated in skeletal muscle cells exhibit weight loss, skeletal muscle atrophy and fibrosis, and alterations glycolysis and fatty acid levels in muscle fibers.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    20
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    837
  • Tissues
    16
  • cDNA Data
    91
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 17713 NCBI Gene Model | MGI Sequence Detail 8893 C57BL/6J ±  kb
    transcript NM_024478 RefSeq | MGI Sequence Detail 3338 C57BL/6  
    polypeptide Q99LP6 UniProt | EBI | MGI Sequence Detail 217 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • Protein Ontology
      PR:000008272 GrpE protein homolog 1, mitochondrial
      (term hierarchy)
    • InterPro Domains
      IPR000740 GrpE nucleotide exchange factor
      IPR013805 GrpE nucleotide exchange factor, coiled-coil
      IPR009012 GrpE nucleotide exchange factor, head
    • GlyGen
      Q99LP6 1 site, 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 91
      cDNA 91

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2140740
    References
    more
    • Summaries
      All 60
      Developmental Gene Expression 2
      Diseases 1
      Gene Ontology 8
      Phenotypes 30
    • Earliest
      J:5021 Batchelor AL, et al., A comparison of the mutagenic effectiveness of chronic neutron- and gamma-irradiation of mouse spermatogonia. Mutat Res. 1966 Jun;3(3):218-29
    • Latest
      J:330869 Neupane N, et al., Inter-organellar and systemic responses to impaired mitochondrial matrix protein import in skeletal muscle. Commun Biol. 2022 Oct 5;5(1):1060
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    11/12/2024
    MGI 6.24     		The Jackson Laboratory