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Uap1 Gene Detail
Summary
  • Symbol
    Uap1
  • Name
    UDP-N-acetylglucosamine pyrophosphorylase 1
  • Synonyms
    AgX, AGX1, ESTM38, SPAG2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1334459
    NCBI Gene: 107652
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:169969507-170002526 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 76.84 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    1078 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1334459
 protein coding gene Chr1:169967473-170002526 (-)
129S1/SvImJ MGP_129S1SvImJ_G0016725
 protein coding gene Chr1:175828005-175863456 (-)
A/J MGP_AJ_G0016705
 protein coding gene Chr1:168639080-168672602 (-)
AKR/J MGP_AKRJ_G0016671
 protein coding gene Chr1:173724617-173757683 (-)
BALB/cJ MGP_BALBcJ_G0016666
 protein coding gene Chr1:169136597-169171873 (-)
C3H/HeJ MGP_C3HHeJ_G0016490
 protein coding gene Chr1:173971285-174006830 (-)
C57BL/6NJ MGP_C57BL6NJ_G0017127
 protein coding gene Chr1:181656322-181693198 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014836
 protein coding gene Chr1:160397665-160429923 (-)
CAST/EiJ MGP_CASTEiJ_G0016070
 protein coding gene Chr1:173599199-173636320 (-)
CBA/J MGP_CBAJ_G0016465
 protein coding gene Chr1:188108667-188143646 (-)
DBA/2J MGP_DBA2J_G0016571
 protein coding gene Chr1:167520069-167553550 (-)
FVB/NJ MGP_FVBNJ_G0016569
 protein coding gene Chr1:165884467-165917272 (-)
LP/J MGP_LPJ_G0016642
 protein coding gene Chr1:176886093-176922621 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0016594
 protein coding gene Chr1:195448315-195488552 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0017164
 protein coding gene Chr1:173611369-173647524 (-)
PWK/PhJ MGP_PWKPhJ_G0015856
 protein coding gene Chr1:166750835-166787530 (-)
SPRET/EiJ MGP_SPRETEiJ_G0015642
 protein coding gene Chr1:172368603-172402122 (-)
WSB/EiJ MGP_WSBEiJ_G0016132
 protein coding gene Chr1:173730333-173766189 (-)



Homology
more
  • Human Ortholog
    UAP1, UDP-N-acetylglucosamine pyrophosphorylase 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    UAP1, UDP-N-acetylglucosamine pyrophosphorylase 1
  • Synonyms
    AGX, AGX1, AGX2, SPAG2
  • Links
    NCBI Gene ID: 6675
    neXtProt AC: NX_Q16222
    UniProt: Q16222

  • Chr Location
    1q23.3; chr1:162561531-162601240 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    20
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    800
  • Tissues
    94
  • cDNA Data
    77
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000026670 Ensembl Gene Model | MGI Sequence Detail 33020 C57BL/6J ±  kb
    transcript ENSMUST00000111351 Ensembl | MGI Sequence Detail 2287 Not Applicable  
    polypeptide ENSMUSP00000106983 Ensembl | MGI Sequence Detail 522 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 78
      cDNA 77
      Primer pair 1

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGI:2138098
    References
    more
    • Summaries
      All 45
      Developmental Gene Expression 4
      Gene Ontology 8
      Phenotypes 11
    • Earliest
      J:52606 Eddleston J, et al., Physical and transcriptional map of a 3-Mb region of mouse chromosome 1 containing the gene for the neural tube defect mutant loop-tail (Lp). Genomics. 1999 Mar 1;56(2):149-59
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory