Slc22a2 MGI Mouse Gene Detail - MGI:1335072 - solute carrier family 22 (organic cation transporter), member 2

Symbol

Slc22a2
Name

solute carrier family 22 (organic cation transporter), member 2
Synonyms

MGC:18339, Oct2, Orct2

Feature Type

protein coding gene
IDs

MGI:1335072
NCBI Gene: 20518
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr17:12803076-12847376 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 17, 8.61 cM
Mapping Data

6 experiments

SNPs within 2kb

1093 from dbSNP Build 142
Strain Annotations

18
PCR

1
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1335072	protein coding gene	Chr17:12803019-12847376 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0023147	protein coding gene	Chr17:10249538-10292838 (+)
A/J	MGP_AJ_G0023115	protein coding gene	Chr17:10076324-10120553 (+)
AKR/J	MGP_AKRJ_G0023079	protein coding gene	Chr17:9904873-9947618 (+)
BALB/cJ	MGP_BALBcJ_G0023115	protein coding gene	Chr17:9849446-9892757 (+)
C3H/HeJ	MGP_C3HHeJ_G0022878	protein coding gene	Chr17:10150664-10192307 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0023558	protein coding gene	Chr17:10630169-10676175 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0021050	protein coding gene	Chr17:4326337-4378754 (-)
CAST/EiJ	MGP_CASTEiJ_G0022392	protein coding gene	Chr17:10226942-10272506 (+)
CBA/J	MGP_CBAJ_G0022850	protein coding gene	Chr17:11021646-11075130 (+)
DBA/2J	MGP_DBA2J_G0022983	protein coding gene	Chr17:9704117-9755482 (+)
FVB/NJ	MGP_FVBNJ_G0022953	protein coding gene	Chr17:9653170-9695797 (+)
LP/J	MGP_LPJ_G0023055	protein coding gene	Chr17:10058029-10100626 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0022972	protein coding gene	Chr17:10635493-10685513 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0023584	protein coding gene	Chr17:10166992-10213678 (+)
PWK/PhJ	MGP_PWKPhJ_G0022140	protein coding gene	Chr17:9405905-9451027 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0021970	protein coding gene	Chr17:9592532-9635237 (+)
WSB/EiJ	MGP_WSBEiJ_G0022449	protein coding gene	Chr17:10487639-10533899 (+)

Human Ortholog

SLC22A2, solute carrier family 22 member 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SLC22A2, solute carrier family 22 member 2
Synonyms

OCT2
Links

HGNC:10966

NCBI Gene ID: 6582

neXtProt AC: NX_O15244

UniProt: O15244
Chr Location

6q25.3; chr6:160171061-160277638 (-) GRCh38

MGI Vertebrate Homology

Slc22a2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: SLC22A2
Gene Tree

Slc22a2

Diseases

1 with human SLC22A2 associations

				Human Disease	Mouse Models
				acute kidney failure IDs acute kidney failure DOID:3021 MESH:D058186

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
1 phenotype from multigenic genotypes
15 phenotype references

All Mutations and Alleles

7
Endonuclease-mediated

3
Targeted

4
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

40 strains or lines available

Mice homozygous for a knockout allele are viable and fertile and display no obvious phenotypic abnormalities. No significant defects in the renal secretion of a model organic cation are observed.

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All GO Annotations

122
GO References

9

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

937
Tissues

160
cDNA Data

28
Literature Summary

14

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase slc22a2

ZFIN slc22a2

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All Sequences

38
RefSeq

4
UniProt

1
CCDS

CCDS28392.1, CCDS88992.1

Ensembl

ENSMUSG00000040966 (Evidence)
NCBI Gene

20518

			Length	Strain/Species	Flank
genomic	20518	NCBI Gene Model \| MGI Sequence Detail	44301	C57BL/6J	± kb
transcript	NM_013667	RefSeq \| MGI Sequence Detail	2139	ZRU/MplStud
polypeptide	O70577	UniProt \| EBI \| MGI Sequence Detail	553	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000014988 solute carrier family 22 member 2

(term hierarchy)
InterPro Domains

IPR005828 Major facilitator, sugar transporter-like

IPR020846 Major facilitator superfamily domain

IPR036259 MFS transporter superfamily

IPR004749 Organic cation transport protein/SVOP

IPR005829 Sugar transporter, conserved site
GlyGen

O70577 1 site

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All nucleic 42

Genomic 6

cDNA 28

Primer pair 8

Microarray probesets 3

Summaries

All 63

Developmental Gene Expression 14

Gene Ontology 9

Phenotypes 15
Earliest

J:47780 Koehler MR, et al., The two human organic cation transporter genes SLC22A1 and SLC22A2 are located on chromosome 6q26. Cytogenet Cell Genet. 1997;79(3-4):198-200
Latest

J:339165 Hucke A, et al., Role of Mouse Organic Cation Transporter 2 for Nephro- and Peripheral Neurotoxicity Induced by Chemotherapeutic Treatment with Cisplatin. Int J Mol Sci. 2023 Jul 14;24(14)

TSS for Slc22a2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr142618	Chr17:12803070-12803082 (+)	0 bp
Tssr142619	Chr17:12803102-12803123 (+)	37 bp
Tssr142620	Chr17:12815231-12815247 (+)	12,163 bp
Tssr142621	Chr17:12833594-12833603 (+)	30,523 bp
Tssr142622	Chr17:12833636-12833642 (+)	30,563 bp
Tssr142623	Chr17:12834170-12834177 (+)	31,098 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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