Casp14 MGI Mouse Gene Detail - MGI:1335092

Symbol

Casp14
Name

caspase 14
Synonyms

MICE, mini-ICE

Feature Type

protein coding gene
IDs

MGI:1335092
NCBI Gene: 12365
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr10:78547825-78554128 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 10, 39.72 cM, cytoband C1
Mapping Data

2 experiments

SNPs within 2kb

255 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1335092	protein coding gene	Chr10:78547825-78554181 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0017428	protein coding gene	Chr10:79174734-79180988 (-)
A/J	MGP_AJ_G0017406	protein coding gene	Chr10:76417857-76424113 (-)
AKR/J	MGP_AKRJ_G0017369	protein coding gene	Chr10:78466443-78472683 (-)
BALB/cJ	MGP_BALBcJ_G0017368	protein coding gene	Chr10:76587044-76593298 (-)
C3H/HeJ	MGP_C3HHeJ_G0017191	protein coding gene	Chr10:78573650-78579892 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0017824	protein coding gene	Chr10:81967163-81973423 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015515	protein coding gene	Chr10:72727215-72733351 (-)
CAST/EiJ	MGP_CASTEiJ_G0016761	protein coding gene	Chr10:78876763-78883022 (-)
CBA/J	MGP_CBAJ_G0017163	protein coding gene	Chr10:85097516-85103725 (-)
DBA/2J	MGP_DBA2J_G0017271	protein coding gene	Chr10:75650153-75656403 (-)
FVB/NJ	MGP_FVBNJ_G0017263	protein coding gene	Chr10:74833779-74840033 (-)
LP/J	MGP_LPJ_G0017342	protein coding gene	Chr10:79625749-79631973 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0017290	protein coding gene	Chr10:87064819-87071079 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0017866	protein coding gene	Chr10:78516123-78522365 (-)
PWK/PhJ	MGP_PWKPhJ_G0016543	protein coding gene	Chr10:75538497-75545343 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0016328	protein coding gene	Chr10:77711472-77718732 (-)
WSB/EiJ	MGP_WSBEiJ_G0016821	protein coding gene	Chr10:78501444-78507647 (-)

Human Ortholog

CASP14, caspase 14

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CASP14, caspase 14
Synonyms

ARCI12, caspase-14
Links

HGNC:1502

NCBI Gene ID: 23581

neXtProt AC: NX_P31944

UniProt: P31944
Chr Location

19p13.12; chr19:15049480-15058293 (+) GRCh38

MGI Vertebrate Homology

Casp14 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: CASP14
Gene Tree

Casp14

Diseases

1 with human CASP14 associations

				Human Disease	Mouse Models
				autosomal recessive congenital ichthyosis IDs autosomal recessive congenital ichthyosis DOID:0060655 DOID:1696 ICD10CM:Q80.2 MESH:D017490 NCI:C84805 OMIM:PS242300 ORDO:281097 UMLS_CUI:C0079154

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

11 phenotypes from 2 alleles in 2 genetic backgrounds
17 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

6
Chemically induced (other)

1
Endonuclease-mediated

3
Targeted

2
Genomic Mutations

1 involving Casp14
Incidental Mutations

APF
Find Mice (IMSR)

14 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele exhibit impaired skin barrier function, skin dehydration and increased damage in response to UVB irradiation.

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All GO Annotations

22
GO References

9

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

767
Tissues

37
cDNA Data

20
Literature Summary

13

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

42
RefSeq

4
UniProt

2
CCDS

CCDS23969.1

Ensembl

ENSMUSG00000005355 (Evidence)
NCBI Gene

12365

			Length	Strain/Species	Flank
genomic	ENSMUSG00000005355	Ensembl Gene Model \| MGI Sequence Detail	6304	C57BL/6J	± kb
transcript	ENSMUST00000005488	Ensembl \| MGI Sequence Detail	2336	Not Applicable
polypeptide	ENSMUSP00000005488	Ensembl \| MGI Sequence Detail	257	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000005054 caspase-14

(term hierarchy)
EC

3.4.22.-
InterPro Domains

IPR029030 Caspase-like domain superfamily

IPR015917 Peptidase C14A, caspase catalytic domain

IPR011600 Peptidase C14, caspase domain

IPR002138 Peptidase C14, caspase non-catalytic subunit p10

IPR001309 Peptidase C14, p20 domain

IPR033139 Peptidase family C14A, cysteine active site

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All nucleic 22

cDNA 20

Primer pair 2

Microarray probesets 4

Summaries

All 57

Developmental Gene Expression 13

Gene Ontology 9

Phenotypes 17
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:352165 Lin Y, et al., Denticleless E3 ubiquitin protein ligase (DTL) maintains the proliferation and differentiation of epidermis and hair follicles during skin development. Dev Dyn. 2024 Jul;253(7):635-647

TSS for Casp14:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr98319	Chr10:78554104-78554138 (-)	7 bp
Tssr98318	Chr10:78548810-78548812 (-)	5,317 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24