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Septin7 Gene Detail
Summary
  • Symbol
    Septin7
  • Name
    septin 7
  • Synonyms
    Cdc10, Sept7
  • Feature Type
    protein coding gene
  • IDs
    MGI:1335094
    NCBI Gene: 235072
  • Alliance
    gene page
  • Transcription Start Sites
    24 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:25163735-25219867 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 10.25 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    1452 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1335094
 protein coding gene Chr9:25163287-25219867 (+)
129S1/SvImJ MGP_129S1SvImJ_G0034497
 protein coding gene Chr9:22663926-22722674 (+)
A/J MGP_AJ_G0034475
 protein coding gene Chr9:22182693-22239217 (+)
AKR/J MGP_AKRJ_G0034401
 protein coding gene Chr9:22611561-22667588 (+)
BALB/cJ MGP_BALBcJ_G0034466
 protein coding gene Chr9:22079385-22136030 (+)
C3H/HeJ MGP_C3HHeJ_G0034178
 protein coding gene Chr9:22944913-23001151 (+)
C57BL/6NJ MGP_C57BL6NJ_G0034987
 protein coding gene Chr9:23531054-23597224 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031917
 protein coding gene Chr9:21131876-21211188 (+)
CAST/EiJ MGP_CASTEiJ_G0033500
 protein coding gene Chr9:22816999-22882336 (+)
CBA/J MGP_CBAJ_G0034151
 protein coding gene Chr9:24400623-24462031 (+)
DBA/2J MGP_DBA2J_G0034309
 protein coding gene Chr9:22165983-22222730 (+)
FVB/NJ MGP_FVBNJ_G0034252
 protein coding gene Chr9:21654822-21712537 (+)
LP/J MGP_LPJ_G0034395
 protein coding gene Chr9:22843065-22906481 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0034296
 protein coding gene Chr9:26016250-26098133 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0035007
 protein coding gene Chr9:22600373-22660347 (+)
PWK/PhJ MGP_PWKPhJ_G0033206
 protein coding gene Chr9:22104103-22163704 (+)
SPRET/EiJ MGP_SPRETEiJ_G0033040
 protein coding gene Chr9:22653363-22714572 (+)
WSB/EiJ MGP_WSBEiJ_G0033616
 protein coding gene Chr9:22320725-22381723 (+)



Homology
more
  • Human Ortholog
    SEPTIN7, septin 7
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SEPTIN7, septin 7
  • Synonyms
    CDC10, CDC3, NBLA02942, SEPT7, SEPT7A, Septin-7
  • Links
    NCBI Gene ID: 989
    neXtProt AC: NX_Q16181
    UniProt: Q16181

  • Chr Location
    7p14.2; chr7:35800932-35915763 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotypes from 3 alleles in 4 genetic backgrounds
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a conditional allele activated in neurons exhibit reduced axon and dendrite length and complexity. Mice homozygous for a knock-out allele die prior to E10.5.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    64
  • GO References
    15
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    849
  • Tissues
    115
  • cDNA Data
    11
  • Literature Summary
    10
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000001833 Ensembl Gene Model | MGI Sequence Detail 56133 C57BL/6J ±  kb
transcript ENSMUST00000115272 Ensembl | MGI Sequence Detail 2533 Not Applicable  
polypeptide ENSMUSP00000110927 Ensembl | MGI Sequence Detail 437 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 15
    cDNA 11
    Primer pair 3
    Other 1

    Microarray probesets 4
Other
Accession IDs
less
MGI:6368836
References
more
  • Summaries
    All 57
    Developmental Gene Expression 10
    Gene Ontology 15
    Phenotypes 18
  • Earliest
    J:50856 Soulier S, et al., Sequence of murine CDC10 cDNA, gene organization and expression analysis. Biochim Biophys Acta. 1998 Nov 8;1442(2-3):339-46
  • Latest
    J:340454 Szabo L, et al., Reduced Expression of Septin7 Hinders Skeletal Muscle Regeneration. Int J Mol Sci. 2023 Aug 31;24(17)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory