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Prkag2 Gene Detail
Summary
  • Symbol
    Prkag2
  • Name
    protein kinase, AMP-activated, gamma 2 non-catalytic subunit
  • Synonyms
    2410051C13Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1336153
    NCBI Gene: 108099
  • Alliance
    gene page
  • Transcription Start Sites
    23 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:25067742-25305640 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 11.93 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    7700 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1336153
 protein coding gene Chr5:25067733-25311576 (-)
129S1/SvImJ MGP_129S1SvImJ_G0029357
 protein coding gene Chr5:22625468-22884896 (-)
A/J MGP_AJ_G0029323
 protein coding gene Chr5:21835821-22086702 (-)
AKR/J MGP_AKRJ_G0029274
 protein coding gene Chr5:22720509-22978435 (-)
BALB/cJ MGP_BALBcJ_G0029334
 protein coding gene Chr5:22349505-22594048 (-)
C3H/HeJ MGP_C3HHeJ_G0029054
 protein coding gene Chr5:22830519-23080960 (-)
C57BL/6NJ MGP_C57BL6NJ_G0029787
 protein coding gene Chr5:24135034-24392574 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027025
 protein coding gene Chr5:19766567-20009692 (-)
CAST/EiJ MGP_CASTEiJ_G0028466
 protein coding gene Chr5:22031689-22284080 (-)
CBA/J MGP_CBAJ_G0029021
 protein coding gene Chr5:24550741-24824233 (-)
DBA/2J MGP_DBA2J_G0029172
 protein coding gene Chr5:22124846-22365644 (-)
FVB/NJ MGP_FVBNJ_G0029130
 protein coding gene Chr5:21502552-21742585 (-)
LP/J MGP_LPJ_G0029256
 protein coding gene Chr5:23028484-23288803 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0029159
 protein coding gene Chr5:25634734-25887895 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0029821
 protein coding gene Chr5:22361962-22612230 (-)
PWK/PhJ MGP_PWKPhJ_G0028190
 protein coding gene Chr5:21222575-21471293 (-)
SPRET/EiJ MGP_SPRETEiJ_G0028021
 protein coding gene Chr5:21709358-21959928 (-)
WSB/EiJ MGP_WSBEiJ_G0028546
 protein coding gene Chr5:22443155-22694594 (-)



Homology
more
  • Human Ortholog
    PRKAG2, protein kinase AMP-activated non-catalytic subunit gamma 2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PRKAG2, protein kinase AMP-activated non-catalytic subunit gamma 2
  • Synonyms
    AAKG, AAKG2, CMH6, H91620p, WPWS
  • Links
    NCBI Gene ID: 51422
    neXtProt AC: NX_Q9UGJ0
    UniProt: Q9UGJ0

  • Chr Location
    7q36.1; chr7:151556124-151877214 (-)  GRCh38
Human Diseases
more
  • Diseases
    4 with human PRKAG2 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    20 phenotypes from 2 alleles in 3 genetic backgrounds
    1 phenotype from multigenic genotypes
    28 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous constitutively active mutants develop age related obesity caused by polyphagia, glucose intolerance and insulin resistance and exhibit slowing of heart rate.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    47
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    888
  • Tissues
    130
  • cDNA Data
    14
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000028944 Ensembl Gene Model | MGI Sequence Detail 237899 C57BL/6J ±  kb
    transcript ENSMUST00000030784 Ensembl | MGI Sequence Detail 3331 Not Applicable  
    polypeptide ENSMUSP00000030784 Ensembl | MGI Sequence Detail 566 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 25
      cDNA 14
      Primer pair 10
      Other 1

      Microarray probesets 9
    Other
    Accession IDs
    less
    MGI:1920950, MGI:2141005
    References
    more
    • Summaries
      All 67
      Developmental Gene Expression 4
      Diseases 1
      Gene Ontology 8
      Phenotypes 28
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory