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Klrc2 Gene Detail
Summary
  • Symbol
    Klrc2
  • Name
    killer cell lectin-like receptor subfamily C, member 2
  • Synonyms
    NKG2C
  • Feature Type
    protein coding gene
  • IDs
    MGI:1336162
    NCBI Gene: 16642
  • Alliance
    gene page
Location &
Maps
more
  • Sequence Map
    Chr6:129626565-129637700 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 63.44 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    240 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1336162
 protein coding gene Chr6:129624459-129637700 (-)
129S1/SvImJ MGP_129S1SvImJ_G0031356
 protein coding gene Chr6:133318657-133349162 (-)
A/J MGP_AJ_G0031327
 protein coding gene Chr6:128223017-128235242 (-)
AKR/J MGP_AKRJ_G0031255
 protein coding gene Chr6:131724385-131739190 (-)
BALB/cJ MGP_BALBcJ_G0031334
 protein coding gene Chr6:127875283-127889031 (-)
C3H/HeJ MGP_C3HHeJ_G0031058
 protein coding gene Chr6:131920813-131933843 (-)
C57BL/6NJ MGP_C57BL6NJ_G0031793
 protein coding gene Chr6:136826178-136864163 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028938
 protein coding gene Chr6:126578400-126591444 (-)
CAST/EiJ MGP_CASTEiJ_G0030436
 protein coding gene Chr6:132182564-132195515 (-)
CBA/J MGP_CBAJ_G0031018
 protein coding gene Chr6:142216018-142228124 (-)
DBA/2J MGP_DBA2J_G0031175
 protein coding gene Chr6:127174795-127187818 (-)
FVB/NJ MGP_FVBNJ_G0031125
 protein coding gene Chr6:126064376-126080891 (-)
LP/J MGP_LPJ_G0031255
 protein coding gene Chr6:133544695-133559956 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0031164
 protein coding gene Chr6:146098733-146112987 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0031826
 protein coding gene Chr6:131802076-131814133 (-)
PWK/PhJ MGP_PWKPhJ_G0030154
 protein coding gene Chr6:125460536-125476981 (-)
SPRET/EiJ MGP_SPRETEiJ_G0029983
 protein coding gene Chr6:129810713-129836087 (-)
WSB/EiJ MGP_WSBEiJ_G0030524
 protein coding gene Chr6:132224546-132235883 (-)



Homology
more
  • Human Ortholog
    KLRC2, killer cell lectin like receptor C2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    KLRC2, killer cell lectin like receptor C2
  • Synonyms
    CD159c, NKG2-C, NKG2C
  • Links
    NCBI Gene ID: 3822
    neXtProt AC: NX_P26717
    UniProt: P26717

  • Chr Location
    12p13.2; chr12:10426854-10442300 (-)  GRCh38
  • Human Ortholog
    KLRC4, killer cell lectin like receptor C4
  • Synonyms
    NKG2-F, NKG2F
  • Links
    NCBI Gene ID: 8302
    neXtProt AC: NX_O43908
    UniProt: O43908

  • Chr Location
    12p13.2; chr12:10407384-10409757 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotype references
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    10
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    2
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 16642 NCBI Gene Model | MGI Sequence Detail 11136 C57BL/6J ±  kb
transcript NM_010653 RefSeq | MGI Sequence Detail 717 C57BL/6  
polypeptide NP_034783 RefSeq | MGI Sequence Detail 238 C57BL/6  
For the selected sequence
Protein
Information
less
  • UniProt
    4 Sequences
  • InterPro Domains
    IPR016187 C-type lectin fold
    IPR001304 C-type lectin-like
    IPR016186 C-type lectin-like/link domain superfamily
    IPR033992 Natural killer cell receptor-like, C-type lectin-like domain
    IPR050919 NKG2/CD94 Natural Killer Receptors
Molecular
Reagents
less
  • All nucleic 3
    cDNA 3

    Microarray probesets 2
References
more
  • Summaries
    All 21
    Gene Ontology 3
    Phenotypes 3
  • Earliest
    J:53413 Lohwasser S, et al., Cloning of murine NKG2A, B and C: second family of C-type lectin receptors on murine NK cells. Eur J Immunol. 1999 Mar;29(3):755-61
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory