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Mybpc2 Gene Detail
Summary
  • Symbol
    Mybpc2
  • Name
    myosin binding protein C, fast-type
  • Synonyms
    Fast-type C-protein, MGC:28149
  • Feature Type
    protein coding gene
  • IDs
    MGI:1336170
    NCBI Gene: 233199
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:44151123-44174080 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 28.83 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    660 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1336170
 protein coding gene Chr7:44151123-44174093 (-)
129S1/SvImJ MGP_129S1SvImJ_G0032166
 protein coding gene Chr7:44675606-44704983 (-)
A/J MGP_AJ_G0032145
 protein coding gene Chr7:43858028-43887131 (-)
AKR/J MGP_AKRJ_G0032081
 protein coding gene Chr7:45060749-45092645 (-)
BALB/cJ MGP_BALBcJ_G0032157
 protein coding gene Chr7:43854117-43883163 (-)
C3H/HeJ MGP_C3HHeJ_G0031873
 protein coding gene Chr7:45552673-45583091 (-)
C57BL/6NJ MGP_C57BL6NJ_G0032649
 protein coding gene Chr7:46933321-46964363 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0029663
 protein coding gene Chr7:46443364-46467078 (-)
CAST/EiJ MGP_CASTEiJ_G0031201
 protein coding gene Chr7:36928495-36957354 (-)
CBA/J MGP_CBAJ_G0031837
 protein coding gene Chr7:48463248-48504387 (-)
DBA/2J MGP_DBA2J_G0031995
 protein coding gene Chr7:43532355-43561168 (-)
FVB/NJ MGP_FVBNJ_G0031946
 protein coding gene Chr7:43270665-43296787 (-)
LP/J MGP_LPJ_G0032073
 protein coding gene Chr7:45358050-45391004 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0031983
 protein coding gene Chr7:47208357-47240759 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0032665
 protein coding gene Chr7:44277012-44313337 (-)
PWK/PhJ MGP_PWKPhJ_G0030924
 protein coding gene Chr7:36880017-36904468 (-)
SPRET/EiJ MGP_SPRETEiJ_G0030761
 protein coding gene Chr7:32285060-32316423 (-)
WSB/EiJ MGP_WSBEiJ_G0031318
 protein coding gene Chr7:44739398-44769702 (-)



Homology
more
  • Human Ortholog
    MYBPC2, myosin binding protein C2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MYBPC2, myosin binding protein C2
  • Synonyms
    fsMyBP-C, MYBPC, MYBPCF
  • Links
    NCBI Gene ID: 4606
    neXtProt AC: NX_Q14324
    UniProt: Q14324

  • Chr Location
    19q13.33; chr19:50432892-50466321 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    13 phenotypes from 1 allele in 1 genetic background
    5 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele show reduced grip strength and plantar flexor muscle strength, reduced speed and force of fast skeletal muscle contraction, and impaired hypertrophic response of EDL muscle fibers to mechanical overload.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    9
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    731
  • Tissues
    15
  • cDNA Data
    31
  • Literature Summary
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000038670 Ensembl Gene Model | MGI Sequence Detail 22958 C57BL/6J ±  kb
    transcript ENSMUST00000165208 Ensembl | MGI Sequence Detail 3611 Not Applicable  
    polypeptide ENSMUSP00000130127 Ensembl | MGI Sequence Detail 1136 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 31
      cDNA 31

      Microarray probesets 2
    References
    more
    • Summaries
      All 37
      Developmental Gene Expression 6
      Gene Ontology 4
      Phenotypes 5
    • Earliest
      J:32589 Schiaffino S, et al., Molecular diversity of myofibrillar proteins: gene regulation and functional significance. Physiol Rev. 1996 Apr;76(2):371-423
    • Latest
      J:351081 Fukushima T, et al., PHF2 regulates sarcomeric gene transcription in myogenesis. PLoS One. 2024;19(5):e0301690
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory