Gng12 MGI Mouse Gene Detail - MGI:1336171 - guanine nucleotide binding protein (G protein), gamma 12

Symbol

Gng12
Name

guanine nucleotide binding protein (G protein), gamma 12
Synonyms

2010305F15Rik

Feature Type

protein coding gene
IDs

MGI:1336171
NCBI Gene: 14701
Alliance

gene page
Transcription Start Sites

12 TSS

Sequence Map

Chr6:66873381-66998334 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 6, 30.68 cM
Mapping Data

4 experiments

SNPs within 2kb

2919 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1336171	protein coding gene	Chr6:66873381-66998345 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0030842	protein coding gene	Chr6:66864089-66988255 (+)
A/J	MGP_AJ_G0030812	protein coding gene	Chr6:63986191-64101882 (+)
AKR/J	MGP_AKRJ_G0030740	protein coding gene	Chr6:65985694-66104403 (+)
BALB/cJ	MGP_BALBcJ_G0030823	protein coding gene	Chr6:64351097-64476430 (+)
C3H/HeJ	MGP_C3HHeJ_G0030889	protein coding gene	Chr6:118042335-118158752 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0031281	protein coding gene	Chr6:68460507-68585875 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0028470	protein coding gene	Chr6:61161346-61279586 (+)
CAST/EiJ	MGP_CASTEiJ_G0029931	protein coding gene	Chr6:66273995-66393748 (+)
CBA/J	MGP_CBAJ_G0030510	protein coding gene	Chr6:71299391-71414714 (+)
DBA/2J	MGP_DBA2J_G0030662	protein coding gene	Chr6:63640516-63760960 (+)
FVB/NJ	MGP_FVBNJ_G0030615	protein coding gene	Chr6:63152232-63270614 (+)
LP/J	MGP_LPJ_G0030741	protein coding gene	Chr6:66786592-66920564 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0030650	protein coding gene	Chr6:75002600-75124347 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0031307	protein coding gene	Chr6:65902093-66025426 (+)
PWK/PhJ	MGP_PWKPhJ_G0029646	protein coding gene	Chr6:62839585-62959191 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0029475	protein coding gene	Chr6:65472845-65595412 (+)
WSB/EiJ	MGP_WSBEiJ_G0030013	protein coding gene	Chr6:66220756-66345622 (+)

Human Ortholog

GNG12, G protein subunit gamma 12

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

GNG12, G protein subunit gamma 12
Synonyms

HG3A
Links

HGNC:19663

NCBI Gene ID: 55970

neXtProt AC: NX_Q9UBI6

UniProt: Q9UBI6
Chr Location

1p31.3; chr1:67701475-67833467 (-) GRCh38

MGI Vertebrate Homology

Gng12 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: GNG12
Gene Tree

Gng12

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Phenotype Summary

9 phenotypes from 2 alleles in 2 genetic backgrounds
9 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

48
Endonuclease-mediated

4
Gene trapped

42
Targeted

2
Find Mice (IMSR)

46 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

11
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

779
Tissues

25
cDNA Data

185
Literature Summary

5

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

Xenbase gng12

ZFIN gng12a, gng12b

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All Sequences

77
RefSeq

18
UniProt

3
CCDS

CCDS39502.1

Ensembl

ENSMUSG00000036402 (Evidence)
NCBI Gene

14701

			Length	Strain/Species	Flank
genomic	ENSMUSG00000036402	Ensembl Gene Model \| MGI Sequence Detail	124954	C57BL/6J	± kb
transcript	ENSMUST00000204511	Ensembl \| MGI Sequence Detail	739	Not Applicable
polypeptide	ENSMUSP00000145346	Ensembl \| MGI Sequence Detail	83	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000008105 guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12

(term hierarchy)
InterPro Domains

IPR015898 G-protein gamma-like domain

IPR036284 G-protein gamma-like domain superfamily

IPR001770 G-protein, gamma subunit

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All nucleic 185

cDNA 185

Microarray probesets 4

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MGI:1889368, MGI:1889384, MGI:1889807, MGI:1919361, MGI:2141487

Summaries

All 41

Developmental Gene Expression 5

Gene Ontology 5

Phenotypes 9
Earliest

J:54663 Downes GB, et al., Chromosomal mapping of five mouse G protein gamma subunits. Genomics. 1999 Apr 1;57(1):173-6
Latest

J:347348 Yim YY, et al., Specificities of Gbetagamma subunits for the SNARE complex before and after stimulation of alpha(2a)-adrenergic receptors. Sci Signal. 2021 Dec 21;14(714):eabc4970

TSS for Gng12:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr56866	Chr6:66873394-66873405 (+)	19 bp
Tssr56867	Chr6:66873413-66873424 (+)	38 bp
Tssr56868	Chr6:66873428-66873463 (+)	65 bp
Tssr56869	Chr6:66873464-66873476 (+)	89 bp
Tssr56870	Chr6:66889626-66889630 (+)	16,247 bp
Tssr56871	Chr6:66895495-66895507 (+)	22,120 bp
Tssr56872	Chr6:66912845-66912861 (+)	39,472 bp
Tssr56873	Chr6:66934010-66934015 (+)	60,632 bp
Tssr56874	Chr6:66940290-66940293 (+)	66,911 bp
Tssr56875	Chr6:66947488-66947518 (+)	74,122 bp
Tssr56876	Chr6:66994482-66994506 (+)	121,113 bp
Tssr56877	Chr6:66994623-66994636 (+)	121,249 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24