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Prkaa2 Gene Detail
Summary
  • Symbol
    Prkaa2
  • Name
    protein kinase, AMP-activated, alpha 2 catalytic subunit
  • Synonyms
    2310008I11Rik, AMPKalpha2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1336173
    NCBI Gene: 108079
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:104887071-104967087 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 49.05 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    2361 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1336173
 protein coding gene Chr4:104886846-104967095 (-)
129S1/SvImJ MGP_129S1SvImJ_G0028514
 protein coding gene Chr4:105556438-105632520 (-)
A/J MGP_AJ_G0028477
 protein coding gene Chr4:101834422-101911689 (-)
AKR/J MGP_AKRJ_G0028424
 protein coding gene Chr4:104315007-104401495 (-)
BALB/cJ MGP_BALBcJ_G0028496
 protein coding gene Chr4:102028655-102108010 (-)
C3H/HeJ MGP_C3HHeJ_G0028210
 protein coding gene Chr4:105074205-105150760 (-)
C57BL/6NJ MGP_C57BL6NJ_G0028936
 protein coding gene Chr4:109447335-109544239 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0026227
 protein coding gene Chr4:97145829-97217541 (-)
CAST/EiJ MGP_CASTEiJ_G0027646
 protein coding gene Chr4:102835554-102918346 (-)
CBA/J MGP_CBAJ_G0028179
 protein coding gene Chr4:112940601-113019837 (-)
DBA/2J MGP_DBA2J_G0028327
 protein coding gene Chr4:101480182-101555190 (-)
FVB/NJ MGP_FVBNJ_G0028295
 protein coding gene Chr4:100321545-100395943 (-)
LP/J MGP_LPJ_G0028428
 protein coding gene Chr4:105754054-105841531 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0028321
 protein coding gene Chr4:118309244-118419735 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0028971
 protein coding gene Chr4:104545749-104636893 (-)
PWK/PhJ MGP_PWKPhJ_G0027372
 protein coding gene Chr4:99683645-99766796 (-)
SPRET/EiJ MGP_SPRETEiJ_G0027196
 protein coding gene Chr4:101914907-102001368 (-)
WSB/EiJ MGP_WSBEiJ_G0027726
 protein coding gene Chr4:104709109-104792847 (-)



Homology
more
  • Human Ortholog
    PRKAA2, protein kinase AMP-activated catalytic subunit alpha 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PRKAA2, protein kinase AMP-activated catalytic subunit alpha 2
  • Synonyms
    AMPK, AMPK2, AMPKa2, PRKAA
  • Links
    NCBI Gene ID: 5563
    neXtProt AC: NX_P54646
    UniProt: P54646

  • Chr Location
    1p32.2; chr1:56645314-56715335 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human PRKAA2 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    41 phenotypes from 4 alleles in 5 genetic backgrounds
    8 phenotypes from multigenic genotypes
    239 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice are hyperglycemic, hypoinsulinemic, and show glucose intolerance and insulin resistance.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    107
  • GO References
    28
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    915
  • Tissues
    60
  • cDNA Data
    58
  • Literature Summary
    43
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000028518 Ensembl Gene Model | MGI Sequence Detail 80017 C57BL/6J ±  kb
    transcript ENSMUST00000030243 Ensembl | MGI Sequence Detail 7969 Not Applicable  
    polypeptide ENSMUSP00000030243 Ensembl | MGI Sequence Detail 552 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 63
      cDNA 60
      Primer pair 3

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:1913766
    References
    more
    • Summaries
      All 395
      Developmental Gene Expression 43
      Gene Ontology 28
      Phenotypes 239
    • Earliest
      J:320077 Salt I, et al., AMP-activated protein kinase: greater AMP dependence, and preferential nuclear localization, of complexes containing the alpha2 isoform. Biochem J. 1998 Aug 15;334 ( Pt 1):177-87
    • Latest
      J:355381 Li Y, et al., Microglial lipid droplet accumulation in tauopathy brain is regulated by neuronal AMPK. Cell Metab. 2024 Apr 16;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/05/2024
    MGI 6.24     		The Jackson Laboratory