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Agpat3 Gene Detail
Summary
  • Symbol
    Agpat3
  • Name
    1-acylglycerol-3-phosphate O-acyltransferase 3
  • Synonyms
    D10Jhu12e, LPAAT3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1336186
    NCBI Gene: 28169
  • Alliance
    gene page
  • Transcription Start Sites
    13 TSS
  • Candidate for QTL
    3 QTL
Location &
Maps
more
  • Sequence Map
    Chr10:78105012-78188323 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 39.72 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1820 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1336186
 protein coding gene Chr10:78105008-78188335 (-)
129S1/SvImJ MGP_129S1SvImJ_G0017420
 protein coding gene Chr10:78709109-78792298 (-)
A/J MGP_AJ_G0017398
 protein coding gene Chr10:75970797-76055296 (-)
AKR/J MGP_AKRJ_G0017361
 protein coding gene Chr10:78006765-78091435 (-)
BALB/cJ MGP_BALBcJ_G0017360
 protein coding gene Chr10:76137040-76220629 (-)
C3H/HeJ MGP_C3HHeJ_G0017183
 protein coding gene Chr10:78110514-78202761 (-)
C57BL/6NJ MGP_C57BL6NJ_G0017816
 protein coding gene Chr10:81486355-81573258 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015507
 protein coding gene Chr10:72307393-72393649 (-)
CAST/EiJ MGP_CASTEiJ_G0016753
 protein coding gene Chr10:78413191-78502317 (-)
CBA/J MGP_CBAJ_G0017155
 protein coding gene Chr10:84592157-84680520 (-)
DBA/2J MGP_DBA2J_G0017263
 protein coding gene Chr10:75212422-75296928 (-)
FVB/NJ MGP_FVBNJ_G0017255
 protein coding gene Chr10:74389931-74474865 (-)
LP/J MGP_LPJ_G0017334
 protein coding gene Chr10:79148005-79236107 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0017282
 protein coding gene Chr10:86574658-86662327 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0017858
 protein coding gene Chr10:78048486-78134853 (-)
PWK/PhJ MGP_PWKPhJ_G0016535
 protein coding gene Chr10:75091611-75177012 (-)
SPRET/EiJ MGP_SPRETEiJ_G0016320
 protein coding gene Chr10:77266349-77350136 (-)
WSB/EiJ MGP_WSBEiJ_G0016813
 protein coding gene Chr10:78040027-78128444 (-)



Homology
more
  • Human Ortholog
    AGPAT3, 1-acylglycerol-3-phosphate O-acyltransferase 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    AGPAT3, 1-acylglycerol-3-phosphate O-acyltransferase 3
  • Synonyms
    1-AGPAT 3, LPAAT3, LPAAT-GAMMA1, LPLAT3
  • Links
    NCBI Gene ID: 56894
    neXtProt AC: NX_Q9NRZ7
    UniProt: Q9NRZ7

  • Chr Location
    21q22.3; chr21:43865223-43987592 (+)  GRCh38
Human Diseases
less
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    25 phenotypes from 1 allele in 3 genetic backgrounds
    45 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit male infertility with oligozoospermia, teratozoospermia.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    12
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    908
  • Tissues
    165
  • cDNA Data
    11
  • Literature Summary
    9
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000001211 Ensembl Gene Model | MGI Sequence Detail 83312 C57BL/6J ±  kb
    transcript ENSMUST00000166360 Ensembl | MGI Sequence Detail 3439 Not Applicable  
    polypeptide ENSMUSP00000132954 Ensembl | MGI Sequence Detail 376 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 28
      Genomic 8
      cDNA 14
      Primer pair 4
      Other 2

      Microarray probesets 8
    Other
    Accession IDs
    less
    MGI:2143803, MGI:2143842
    References
    more
    • Summaries
      All 88
      Developmental Gene Expression 9
      Diseases 2
      Gene Ontology 5
      Phenotypes 45
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:350540 Zhou H, et al., AGPAT3 deficiency impairs adipocyte differentiation and leads to a lean phenotype in mice. Am J Physiol Endocrinol Metab. 2024 Jul 1;327(1):E69-E80
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/05/2024
    MGI 6.24     		The Jackson Laboratory