Slc22a8 MGI Mouse Gene Detail - MGI:1336187 - solute carrier family 22 (organic anion transporter), member 8

Symbol

Slc22a8
Name

solute carrier family 22 (organic anion transporter), member 8
Synonyms

mOat3, OAT3, Roct

Feature Type

protein coding gene
IDs

MGI:1336187
NCBI Gene: 19879
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr19:8568618-8589199 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 19, 5.44 cM
Mapping Data

3 experiments

SNPs within 2kb

476 from dbSNP Build 142
Strain Annotations

18
PCR

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1336187	protein coding gene	Chr19:8568576-8589199 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0024800	protein coding gene	Chr19:5856551-5877069 (+)
A/J	MGP_AJ_G0024768	protein coding gene	Chr19:5543476-5563943 (+)
AKR/J	MGP_AKRJ_G0024743	protein coding gene	Chr19:5625233-5645785 (+)
BALB/cJ	MGP_BALBcJ_G0024768	protein coding gene	Chr19:5643110-5663689 (+)
C3H/HeJ	MGP_C3HHeJ_G0024534	protein coding gene	Chr19:5711802-5732365 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0025215	protein coding gene	Chr19:5967832-5988518 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0022644	protein coding gene	Chr19:5781128-5801551 (+)
CAST/EiJ	MGP_CASTEiJ_G0024007	protein coding gene	Chr19:5357808-5378262 (+)
CBA/J	MGP_CBAJ_G0024508	protein coding gene	Chr19:6082555-6103092 (+)
DBA/2J	MGP_DBA2J_G0024635	protein coding gene	Chr19:5367554-5388135 (+)
FVB/NJ	MGP_FVBNJ_G0024602	protein coding gene	Chr19:5447767-5468230 (+)
LP/J	MGP_LPJ_G0024722	protein coding gene	Chr19:5741512-5762038 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0024629	protein coding gene	Chr19:5950986-5971522 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0025264	protein coding gene	Chr19:5666467-5686933 (+)
PWK/PhJ	MGP_PWKPhJ_G0023752	protein coding gene	Chr19:5034710-5055492 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0023557	protein coding gene	Chr19:5272509-5292954 (+)
WSB/EiJ	MGP_WSBEiJ_G0024069	protein coding gene	Chr19:5635110-5656335 (+)

Human Ortholog

SLC22A8, solute carrier family 22 member 8

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SLC22A8, solute carrier family 22 member 8
Synonyms

OAT3
Links

HGNC:10972

NCBI Gene ID: 9376

neXtProt AC: NX_Q8TCC7

UniProt: Q8TCC7
Chr Location

11q12.3; chr11:62989154-63015841 (-) GRCh38

MGI Vertebrate Homology

Slc22a8 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: SLC22A8
Gene Tree

Slc22a8

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Phenotype Summary

3 phenotypes from 2 alleles in 3 genetic backgrounds
24 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

6
Endonuclease-mediated

1
Targeted

5
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

32 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele exhibit decreased urinary urate levels.

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All GO Annotations

28
GO References

9

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1018
Tissues

129
cDNA Data

48
Literature Summary

7

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase slc22a8l

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All Sequences

54
RefSeq

15
UniProt

1
CCDS

CCDS29537.1

Ensembl

ENSMUSG00000063796 (Evidence)
NCBI Gene

19879

			Length	Strain/Species	Flank
genomic	ENSMUSG00000063796	Ensembl Gene Model \| MGI Sequence Detail	20582	C57BL/6J	± kb
transcript	ENSMUST00000010251	Ensembl \| MGI Sequence Detail	3444	Not Applicable
polypeptide	ENSMUSP00000010251	Ensembl \| MGI Sequence Detail	537	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000014995 organic anion transporter 3

(term hierarchy)
InterPro Domains

IPR005828 Major facilitator, sugar transporter-like

IPR020846 Major facilitator superfamily domain

IPR036259 MFS transporter superfamily

IPR004749 Organic cation transport protein/SVOP
GlyGen

O88909 1 site

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All nucleic 53

Genomic 1

cDNA 48

Primer pair 3

Other 1

Microarray probesets 4

Summaries

All 69

Developmental Gene Expression 7

Gene Ontology 9

Phenotypes 24
Earliest

J:49669 Heaney C, et al., Human autosomal recessive osteopetrosis maps to 11q13, a position predicted by comparative mapping of the murine osteosclerosis (oc) mutation. Hum Mol Genet. 1998 Sep;7(9):1407-10
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Slc22a8:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr154777	Chr19:8568537-8568544 (+)	-77 bp
Tssr154778	Chr19:8568641-8568664 (+)	35 bp
Tssr154779	Chr19:8570539-8570556 (+)	1,930 bp
Tssr154780	Chr19:8571415-8571433 (+)	2,806 bp
Tssr154781	Chr19:8571435-8571491 (+)	2,845 bp
Tssr154782	Chr19:8571511-8571518 (+)	2,897 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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