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Ppp1r13b Gene Detail
Summary
  • Symbol
    Ppp1r13b
  • Name
    protein phosphatase 1, regulatory subunit 13B
  • Synonyms
    ASPP1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1336199
    NCBI Gene: 21981
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:111794891-111874544 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 12, 61.14 cM, cytoband F2
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2231 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1336199
 protein coding gene Chr12:111794891-111874549 (-)
129S1/SvImJ MGP_129S1SvImJ_G0020144
 protein coding gene Chr12:114248808-114333493 (-)
A/J MGP_AJ_G0020100
 protein coding gene Chr12:109858413-109938954 (-)
AKR/J MGP_AKRJ_G0020075
 protein coding gene Chr12:113006685-113096108 (-)
BALB/cJ MGP_BALBcJ_G0020085
 protein coding gene Chr12:110276763-110357358 (-)
C3H/HeJ MGP_C3HHeJ_G0019887
 protein coding gene Chr12:113506091-113592929 (-)
C57BL/6NJ MGP_C57BL6NJ_G0020530
 protein coding gene Chr12:117797045-117885101 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0018143
 protein coding gene Chr12:106291321-106368421 (-)
CAST/EiJ MGP_CASTEiJ_G0019428
 protein coding gene Chr12:108357924-108440293 (-)
CBA/J MGP_CBAJ_G0019854
 protein coding gene Chr12:122296224-122391265 (-)
DBA/2J MGP_DBA2J_G0019971
 protein coding gene Chr12:109333798-109412414 (-)
FVB/NJ MGP_FVBNJ_G0019956
 protein coding gene Chr12:108142368-108226849 (-)
LP/J MGP_LPJ_G0020046
 protein coding gene Chr12:114080232-114162796 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0019994
 protein coding gene Chr12:125401163-125491594 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0020559
 protein coding gene Chr12:112529061-112611526 (-)
PWK/PhJ MGP_PWKPhJ_G0019189
 protein coding gene Chr12:103981927-104063479 (-)
SPRET/EiJ MGP_SPRETEiJ_G0018992
 protein coding gene Chr12:106691498-106772008 (-)
WSB/EiJ MGP_WSBEiJ_G0019487
 protein coding gene Chr12:113435325-113514656 (-)



Homology
more
  • Human Ortholog
    PPP1R13B, protein phosphatase 1 regulatory subunit 13B
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PPP1R13B, protein phosphatase 1 regulatory subunit 13B
  • Synonyms
    ASPP1, p53BP2-like, p85
  • Links
    NCBI Gene ID: 23368
    neXtProt AC: NX_Q96KQ4
    UniProt: Q96KQ4

  • Chr Location
    14q32.33; chr14:103733195-103848814 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 2 alleles in 2 genetic backgrounds
    1 phenotype from multigenic genotypes
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mutants show lymphatic vascular phenotypes with subcutaneous edema detected only during embryogenesis, delayed lymphatic vessel formation, and mispatterned collecting lymphatic vessels.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    17
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    726
  • Tissues
    10
  • cDNA Data
    74
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000021285 Ensembl Gene Model | MGI Sequence Detail 79654 C57BL/6J ±  kb
    transcript ENSMUST00000054815 Ensembl | MGI Sequence Detail 4389 Not Applicable  
    polypeptide ENSMUSP00000062464 Ensembl | MGI Sequence Detail 1087 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      5 Sequences
    • Protein Ontology
      PR:000013110 apoptosis-stimulating of p53 protein 1
      (term hierarchy)
    • InterPro Domains
      IPR002110 Ankyrin repeat
      IPR036770 Ankyrin repeat-containing domain superfamily
      IPR047163 Apoptosis-stimulating of p53 protein 1/2
      IPR028319 Apoptosis-stimulating of p53 protein 1, RA domain
      IPR048942 Apoptosis-stimulating of p53 protein 2-like, RA domain
      IPR001452 SH3 domain
      IPR036028 SH3-like domain superfamily
      IPR029071 Ubiquitin-like domain superfamily
    • GlyGen
      Q62415 3 sites, 1 N-linked glycan (2 sites), 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 75
      cDNA 74
      Primer pair 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2144829, MGI:2145037
    References
    more
    • Summaries
      All 43
      Developmental Gene Expression 3
      Gene Ontology 6
      Phenotypes 12
    • Earliest
      J:35786 Sparks AB, et al., Cloning of ligand targets: systematic isolation of SH3 domain-containing proteins. Nat Biotechnol. 1996 Jun;14(6):741-4
    • Latest
      J:266086 Tsukiji N, et al., Platelets play an essential role in murine lung development through Clec-2/podoplanin interaction. Blood. 2018 Sep 13;132(11):1167-1179
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory