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Fkbp1b Gene Detail
Summary
  • Symbol
    Fkbp1b
  • Name
    FK506 binding protein 1b
  • Synonyms
    12.6kDa, calstabin2, FKBP12.6
  • Feature Type
    protein coding gene
  • IDs
    MGI:1336205
    NCBI Gene: 14226
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:4883174-4891591 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 12, 2.09 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    296 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1336205
 protein coding gene Chr12:4883174-4891736 (-)
129S1/SvImJ MGP_129S1SvImJ_G0019575
 protein coding gene Chr12:1745487-1753907 (-)
A/J MGP_AJ_G0019542
 protein coding gene Chr12:1711036-1719456 (-)
AKR/J MGP_AKRJ_G0019512
 protein coding gene Chr12:1903479-1911899 (-)
BALB/cJ MGP_BALBcJ_G0019517
 protein coding gene Chr12:1750245-1758665 (-)
C3H/HeJ MGP_C3HHeJ_G0019323
 protein coding gene Chr12:1678813-1687233 (-)
C57BL/6NJ MGP_C57BL6NJ_G0019966
 protein coding gene Chr12:1790070-1798490 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0017591
 protein coding gene Chr12:1697079-1705853 (-)
CAST/EiJ MGP_CASTEiJ_G0018878
 protein coding gene Chr12:1766532-1774945 (-)
CBA/J MGP_CBAJ_G0019294
 protein coding gene Chr12:2100740-2109160 (-)
DBA/2J MGP_DBA2J_G0019407
 protein coding gene Chr12:1645867-1654287 (-)
FVB/NJ MGP_FVBNJ_G0019398
 protein coding gene Chr12:1654031-1662451 (-)
LP/J MGP_LPJ_G0019478
 protein coding gene Chr12:1750395-1758815 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0019431
 protein coding gene Chr12:1846284-1854704 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0020005
 protein coding gene Chr12:1720191-1728611 (-)
PWK/PhJ MGP_PWKPhJ_G0018644
 protein coding gene Chr12:1704059-1712648 (-)
SPRET/EiJ MGP_SPRETEiJ_G0018435
 protein coding gene Chr12:1751621-1760051 (-)
WSB/EiJ MGP_WSBEiJ_G0018929
 protein coding gene Chr12:1712866-1721286 (-)



Homology
more
  • Human Ortholog
    FKBP1B, FKBP prolyl isomerase 1B
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    FKBP1B, FKBP prolyl isomerase 1B
  • Synonyms
    FKBP12.6, FKBP1L, OTK4, PKBP1L, PPIase
  • Links
    NCBI Gene ID: 2281
    neXtProt AC: NX_P68106
    UniProt: P68106

  • Chr Location
    2p23.3; chr2:24033206-24063681 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Fkbp1b mouse models; 1 with human FKBP1B associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    19 phenotypes from 4 alleles in 5 genetic backgrounds
    32 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a null allele display exercise-induced sudden cardiac death. Homozygotes for a second null allele show impaired glucose tolerance and glucose-driven insulin secretion. Homozygotes for a third null allele show Ca2+ dysregulation and male-specific cardiac hypertrophy and hypertension.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    62
  • GO References
    20
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    748
  • Tissues
    26
  • cDNA Data
    10
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000020635 Ensembl Gene Model | MGI Sequence Detail 8418 C57BL/6J ±  kb
    transcript ENSMUST00000020964 Ensembl | MGI Sequence Detail 976 Not Applicable  
    polypeptide ENSMUSP00000020964 Ensembl | MGI Sequence Detail 108 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • Protein Ontology
      PR:000007537 peptidyl-prolyl cis-trans isomerase FKBP1B
      (term hierarchy)
    • EC
      5.2.1.8
    • InterPro Domains
      IPR050689 FKBP-type Peptidyl-prolyl cis-trans Isomerase
      IPR001179 FKBP-type peptidyl-prolyl cis-trans isomerase domain
      IPR046357 Peptidyl-prolyl cis-trans isomerase domain superfamily
    Molecular
    Reagents
    less
    • All nucleic 11
      cDNA 10
      Primer pair 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2145031
    References
    more
    • Summaries
      All 70
      Developmental Gene Expression 4
      Diseases 1
      Gene Ontology 20
      Phenotypes 32
    • Earliest
      J:51613 Datta PK, et al., Identification of STRAP, a novel WD domain protein in transforming growth factor-beta signaling. J Biol Chem. 1998 Dec 25;273(52):34671-4
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory