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Trappc10 Gene Detail
Summary
  • Symbol
    Trappc10
  • Name
    trafficking protein particle complex 10
  • Synonyms
    B230307C21Rik, b2b2416Clo, b2b2613Clo, LOC380642, Tmem1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1336209
    NCBI Gene: 216131
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:78022559-78080475 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 39.72 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1404 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1336209
 protein coding gene Chr10:78021256-78080479 (-)
129S1/SvImJ MGP_129S1SvImJ_G0017419
 protein coding gene Chr10:78623739-78684071 (-)
A/J MGP_AJ_G0017397
 protein coding gene Chr10:75886470-75945170 (-)
AKR/J MGP_AKRJ_G0017360
 protein coding gene Chr10:77922732-77982551 (-)
BALB/cJ MGP_BALBcJ_G0017359
 protein coding gene Chr10:76054791-76112751 (-)
C3H/HeJ MGP_C3HHeJ_G0017182
 protein coding gene Chr10:78026292-78084257 (-)
C57BL/6NJ MGP_C57BL6NJ_G0017815
 protein coding gene Chr10:81402987-81461010 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015506
 protein coding gene Chr10:72223474-72282316 (-)
CAST/EiJ MGP_CASTEiJ_G0016752
 protein coding gene Chr10:78329694-78389134 (-)
CBA/J MGP_CBAJ_G0017154
 protein coding gene Chr10:84506723-84587483 (-)
DBA/2J MGP_DBA2J_G0017262
 protein coding gene Chr10:75129484-75187400 (-)
FVB/NJ MGP_FVBNJ_G0017254
 protein coding gene Chr10:74306890-74365040 (-)
LP/J MGP_LPJ_G0017333
 protein coding gene Chr10:79064558-79122493 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0017281
 protein coding gene Chr10:86486919-86546016 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0017857
 protein coding gene Chr10:77964870-78024212 (-)
PWK/PhJ MGP_PWKPhJ_G0016534
 protein coding gene Chr10:75007433-75066919 (-)
SPRET/EiJ MGP_SPRETEiJ_G0016319
 protein coding gene Chr10:77183784-77242091 (-)
WSB/EiJ MGP_WSBEiJ_G0016812
 protein coding gene Chr10:77951390-78012655 (-)



Homology
more
  • Human Ortholog
    TRAPPC10, trafficking protein particle complex subunit 10
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TRAPPC10, trafficking protein particle complex subunit 10
  • Synonyms
    EHOC-1, EHOC1, GT334, NEDMISS, TMEM1, TRS130, TRS30
  • Links
    NCBI Gene ID: 7109
    neXtProt AC: NX_P48553
    UniProt: P48553

  • Chr Location
    21q22.3; chr21:44012309-44106552 (+)  GRCh38
Human Diseases
more
  • Diseases
    2 with Trappc10 mouse models

Human Disease Mouse Models
      
IDs
 View 1 model
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    21 phenotypes from 3 alleles in 3 genetic backgrounds
    27 images
    41 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for ENU-induced mutations exhibit cardiovascular phenotypes, including atrioventricular or ventricular septal defects, thymus hypoplasia, and eye defects such as microphthalmia or anophthalmia. Holoprosencephaly, anencephaly and severe craniofacial defects may be also present.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    11
  • GO References
    4
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    868
  • Tissues
    136
  • cDNA Data
    93
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000000374 Ensembl Gene Model | MGI Sequence Detail 57917 C57BL/6J ±  kb
    transcript ENSMUST00000000384 Ensembl | MGI Sequence Detail 5047 Not Applicable  
    polypeptide ENSMUSP00000000384 Ensembl | MGI Sequence Detail 1258 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000016612 trafficking protein particle complex subunit 10
      (term hierarchy)
    • InterPro Domains
      IPR045126 Trafficking protein particle complex subunit TRAPPC10/Trs130
      IPR022233 TRAPP II complex TRAPPC10, C-terminal
    • GlyGen
      Q3TLI0 2 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 106
      Genomic 8
      cDNA 95
      Primer pair 2
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2685716, MGI:3036257, MGI:5560780, MGI:5615090
    References
    more
    • Summaries
      All 72
      Developmental Gene Expression 5
      Diseases 3
      Gene Ontology 4
      Phenotypes 41
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/05/2024
    MGI 6.24     		The Jackson Laboratory